KOBV Portal

Hits per page

hits 1 - 10 | 140 hits

Sorting

Online Resource

Spatial Distribution of Collagen Type I mRNA inParacentrotus lividusEggs and Embryos

Gambino, Roberto ; Romancino, Daniele P. ; Cervello, Melchiorre ; [et al.]

Elsevier BV ; 1997

In: Biochemical and Biophysical Research Communications Vol. 238, No. 2 ( 1997-09), p. 334-337

add to watchlist on the watchlist

Details

In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 238, No. 2 ( 1997-09), p. 334-337

Type of Medium: Online Resource

ISSN: 0006-291X

URL: Article

DOI: 10.1006/bbrc.1997.7288

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 1997

detail.hit.zdb_id: 1461396-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

McCubrey, James A. ; Steelman, Linda S. ; Kempf, C. Ruth ; [et al.]

Wiley ; 2011

In: Journal of Cellular Physiology Vol. 226, No. 11 ( 2011-11), p. 2762-2781

add to watchlist on the watchlist

Details

In: Journal of Cellular Physiology, Wiley, Vol. 226, No. 11 ( 2011-11), p. 2762-2781

Abstract: Chemotherapy remains a commonly used therapeutic approach for many cancers. Indeed chemotherapy is relatively effective for treatment of certain cancers and it may be the only therapy (besides radiotherapy) that is appropriate for certain cancers. However, a common problem with chemotherapy is the development of drug resistance. Many studies on the mechanisms of drug resistance concentrated on the expression of membrane transporters and how they could be aberrantly regulated in drug resistant cells. Attempts were made to isolate specific inhibitors which could be used to treat drug resistant patients. Unfortunately most of these drug transporter inhibitors have not proven effective for therapy. Recently the possibilities of more specific, targeted therapies have sparked the interest of clinical and basic researchers as approaches to kill cancer cells. However, there are also problems associated with these targeted therapies. Two key signaling pathways involved in the regulation of cell growth are the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways. Dysregulated signaling through these pathways is often the result of genetic alterations in critical components in these pathways as well as mutations in upstream growth factor receptors. Furthermore, these pathways may be activated by chemotherapeutic drugs and ionizing radiation. This review documents how their abnormal expression can contribute to drug resistance as well as resistance to targeted therapy. This review will discuss in detail PTEN regulation as this is a critical tumor suppressor gene frequently dysregulated in human cancer which contributes to therapy resistance. Controlling the expression of these pathways could improve cancer therapy and ameliorate human health. J. Cell. Physiol. 226: 2762–2781, 2011. © 2011 Wiley‐Liss, Inc.

Type of Medium: Online Resource

ISSN: 0021-9541 , 1097-4652

URL: Issue

URL: Article

DOI: 10.1002/jcp.v226.11

DOI: 10.1002/jcp.22647

Language: English

Publisher: Wiley

Publication Date: 2011

detail.hit.zdb_id: 1478143-8

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

Cusimano, Antonella ; Azzolina, Antonina ; Iovanna, Juan L. ; [et al.]

Informa UK Limited ; 2010

In: Cell Cycle Vol. 9, No. 7 ( 2010-04), p. 1399-1410

add to watchlist on the watchlist

Details

In: Cell Cycle, Informa UK Limited, Vol. 9, No. 7 ( 2010-04), p. 1399-1410

Type of Medium: Online Resource

ISSN: 1538-4101 , 1551-4005

URL: Article

DOI: 10.4161/cc.9.7.11254

Language: English

Publisher: Informa UK Limited

Publication Date: 2010

detail.hit.zdb_id: 2102687-7

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Cancer therapy and treatments during COVID-19 era

Akula, Shaw M. ; Abrams, Stephen L. ; Steelman, Linda S. ; [et al.]

Elsevier BV ; 2020

In: Advances in Biological Regulation Vol. 77 ( 2020-08), p. 100739-

add to watchlist on the watchlist

Details

In: Advances in Biological Regulation, Elsevier BV, Vol. 77 ( 2020-08), p. 100739-

Type of Medium: Online Resource

ISSN: 2212-4926

URL: Article

DOI: 10.1016/j.jbior.2020.100739

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2652386-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

Fitzgerald, Timothy L. ; Lertpiriyapong, Kvin ; Cocco, Lucio ; [et al.]

Elsevier BV ; 2015

In: Advances in Biological Regulation Vol. 59 ( 2015-09), p. 65-81

add to watchlist on the watchlist

Details

In: Advances in Biological Regulation, Elsevier BV, Vol. 59 ( 2015-09), p. 65-81

Type of Medium: Online Resource

ISSN: 2212-4926

URL: Article

DOI: 10.1016/j.jbior.2015.06.003

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 2652386-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53

Abrams, Stephen L. ; Akula, Shaw M. ; Martelli, Alberto M. ; [et al.]

Elsevier BV ; 2021

In: Advances in Biological Regulation Vol. 79 ( 2021-01), p. 100780-

add to watchlist on the watchlist

Details

In: Advances in Biological Regulation, Elsevier BV, Vol. 79 ( 2021-01), p. 100780-

Type of Medium: Online Resource

ISSN: 2212-4926

URL: Article

DOI: 10.1016/j.jbior.2020.100780

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2652386-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells

Lampiasi, Nadia ; Foderà, Daniela ; D'Alessandro, Natale ; [et al.]

Spandidos Publications ; 2006

In: International Journal of Molecular Medicine ( 2006-02-01)

add to watchlist on the watchlist

Details

In: International Journal of Molecular Medicine, Spandidos Publications, ( 2006-02-01)

Type of Medium: Online Resource

ISSN: 1107-3756 , 1791-244X

URL: Journal

URL: Article

DOI: 10.3892/ijmm

DOI: 10.3892/ijmm.17.2.245

Language: Unknown

Publisher: Spandidos Publications

Publication Date: 2006

detail.hit.zdb_id: 2083937-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

Augello, Giuseppa ; Emma, Maria Rita ; Cusimano, Antonella ; [et al.]

Wiley ; 2019

In: International Journal of Cancer Vol. 144, No. 10 ( 2019-05-15), p. 2613-2624

add to watchlist on the watchlist

Details

In: International Journal of Cancer, Wiley, Vol. 144, No. 10 ( 2019-05-15), p. 2613-2624

Abstract: What's new? Hepatocellular carcinoma (HCC) exhibits vast molecular heterogeneity, suggesting that therapies aimed against targets that interact with multiple signaling pathways could be key to improving HCC outcome. Here, heat shock protein 90 (HSP90), a modulator of numerous signaling components, was found to be highly expressed in HCC. AUY922, an HSP90 inhibitor, blocked HCC cell growth in vitro and, in HepG2 liver carcinoma cells, induced apoptosis via caspase activation and β‐catenin fragmentation. These effects were not observed in Huh7 or SNU475 HCC cell lines. AUY922 also reduced tumor growth in vivo , marking HSP90 as a promising therapeutic target in HCC.

Type of Medium: Online Resource

ISSN: 0020-7136 , 1097-0215

URL: Issue

URL: Article

DOI: 10.1002/ijc.v144.10

DOI: 10.1002/ijc.31963

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 218257-9

detail.hit.zdb_id: 1474822-8

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

James A. McCubrey ; Linda S. Steelman ; Stephen L. Abrams ; [et al.]

Bentham Science Publishers Ltd. ; 2012

In: Current Pharmaceutical Design Vol. 18, No. 13 ( 2012-04-23), p. 1784-1795

add to watchlist on the watchlist

Details

In: Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 18, No. 13 ( 2012-04-23), p. 1784-1795

Type of Medium: Online Resource

ISSN: 1381-6128

URL: Article

DOI: 10.2174/138161212799859701

Language: English

Publisher: Bentham Science Publishers Ltd.

Publication Date: 2012

SSG: 15,3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon

Cervello, Melchiorre ; McCubrey, James A. ; Cusimano, Antonella ; [et al.]

Impact Journals, LLC ; 2012

In: Oncotarget Vol. 3, No. 3 ( 2012-03-31), p. 236-260

add to watchlist on the watchlist

Details

In: Oncotarget, Impact Journals, LLC, Vol. 3, No. 3 ( 2012-03-31), p. 236-260

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v3i3

DOI: 10.18632/oncotarget.466

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2012

detail.hit.zdb_id: 2560162-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 140 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg