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1

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Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE Nitratase®: a Multicenter Study

Miranda, Silvana Spindola de ; Almeida, Isabela Neves de ; Mansur, Maria de Fátima Filardi Oliveira ; [et al.]

FapUNIFESP (SciELO) ; 2020

In: Brazilian Archives of Biology and Technology Vol. 63 ( 2020)

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In: Brazilian Archives of Biology and Technology, FapUNIFESP (SciELO), Vol. 63 ( 2020)

Type of Medium: Online Resource

ISSN: 1678-4324 , 1516-8913

URL: Article

DOI: 10.1590/1678-4324-2020190179

Language: English

Publisher: FapUNIFESP (SciELO)

Publication Date: 2020

detail.hit.zdb_id: 2122231-9

SSG: 12

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2

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Whole genome sequence of Mycobacterium kansasii isolates of the genotype 1 from Brazilian patients with pulmonary disease demonstrates considerable heterogeneity

Machado, Edson ; Vasconcellos, Sidra Ezidio Gonçalves ; Cerdeira, Camillo ; [et al.]

FapUNIFESP (SciELO) ; 2018

In: Memórias do Instituto Oswaldo Cruz Vol. 113, No. 9 ( 2018-06-25)

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In: Memórias do Instituto Oswaldo Cruz, FapUNIFESP (SciELO), Vol. 113, No. 9 ( 2018-06-25)

Type of Medium: Online Resource

ISSN: 1678-8060 , 0074-0276

URL: Article

DOI: 10.1590/0074-02760180085

Language: Unknown

Publisher: FapUNIFESP (SciELO)

Publication Date: 2018

detail.hit.zdb_id: 2017165-1

SSG: 12

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3

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Phenotypic and molecular characterization of quinolone resistance in Mycobacterium abscessus subsp. bolletii recovered from postsurgical infections

de Moura, Vinicius Calado Nogueira ; da Silva, Marlei Gomes ; Gomes, Karen Machado ; [et al.]

Microbiology Society ; 2012

In: Journal of Medical Microbiology Vol. 61, No. 1 ( 2012-01-01), p. 115-125

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In: Journal of Medical Microbiology, Microbiology Society, Vol. 61, No. 1 ( 2012-01-01), p. 115-125

Type of Medium: Online Resource

ISSN: 0022-2615 , 1473-5644

URL: Article

DOI: 10.1099/jmm.0.034942-0

RVK:

XA 55020

Language: English

Publisher: Microbiology Society

Publication Date: 2012

detail.hit.zdb_id: 2083944-3

SSG: 12

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4

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Multidrug-Resistant Nontuberculous Mycobacteria Isolated from Cystic Fibrosis Patients

Cândido, Pedro Henrique Campanini ; Nunes, Luciana de Souza ; Marques, Elizabeth Andrade ; [et al.]

American Society for Microbiology ; 2014

In: Journal of Clinical Microbiology Vol. 52, No. 8 ( 2014-08), p. 2990-2997

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In: Journal of Clinical Microbiology, American Society for Microbiology, Vol. 52, No. 8 ( 2014-08), p. 2990-2997

Abstract: Worldwide, nontuberculous mycobacteria (NTM) have become emergent pathogens of pulmonary infections in cystic fibrosis (CF) patients, with an estimated prevalence ranging from 5 to 20%. This work investigated the presence of NTM in sputum samples of 129 CF patients (2 to 18 years old) submitted to longitudinal clinical supervision at a regional reference center in Rio de Janeiro, Brazil. From June 2009 to March 2012, 36 NTM isolates recovered from 10 (7.75%) out of 129 children were obtained. Molecular identification of NTM was performed by using PCR restriction analysis targeting the hsp65 gene (PRA- hsp65 ) and sequencing of the rpoB gene, and susceptibility tests were performed that followed Clinical and Laboratory Standards Institute recommendations. For evaluating the genotypic diversity, pulsed-field gel electrophoresis (PFGE) and/or enterobacterial repetitive intergenic consensus sequence PCR (ERIC-PCR) was performed. The species identified were Mycobacterium abscessus subsp. bolletii ( n = 24), M. abscessus subsp. abscessus ( n = 6), Mycobacterium fortuitum ( n = 3), Mycobacterium marseillense ( n = 2), and Mycobacterium timonense ( n = 1). Most of the isolates presented resistance to five or more of the antimicrobials tested. Typing profiles were mainly patient specific. The PFGE profiles indicated the presence of two clonal groups for M. abscessus subsp. abscessus and five clonal groups for M. abscesssus subsp. bolletii , with just one clone detected in two patients. Given the observed multidrug resistance patterns and the possibility of transmission between patients, we suggest the implementation of continuous and routine investigation of NTM infection or colonization in CF patients, including countries with a high burden of tuberculosis disease.

Type of Medium: Online Resource

ISSN: 0095-1137 , 1098-660X

URL: Article

DOI: 10.1128/JCM.00549-14

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2014

detail.hit.zdb_id: 1498353-9

SSG: 12

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5

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PERCUTANEOUS TREATMENT OF ANEURYSMAL BONE CYST WITH CALCITONIN AND METHYLPREDNISOLONE

Oliveira, Marcelo Bragança dos Reis ; Meohas, Walter ; Silva, Ronan Ribeiro ; [et al.]

FapUNIFESP (SciELO) ; 2018

In: Acta Ortopédica Brasileira Vol. 26, No. 5 ( 2018-10), p. 314-319

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In: Acta Ortopédica Brasileira, FapUNIFESP (SciELO), Vol. 26, No. 5 ( 2018-10), p. 314-319

Abstract: RESUMO Objetivo: Apresentar o método de injeção intralesional percutânea de calcitonina e metilprednisolona para promover a ossificação do cisto ósseo aneurismático (COA). Métodos: Foi realizado um estudo retrospectivo de coorte envolvendo 76 pacientes com diagnóstico de COA entre 2005 e 2014. Os pacientes tratados com injeção de calcitonina e metilprednisolona e acompanhados durante mais de dois anos foram considerados elegíveis para o estudo (n = 47). Foram utilizados o sistema de estadiamento de Enneking e a classificação de Capanna durante a avaliação inicial. A resposta ao tratamento foi avaliada pela classificação radiográfica Rastogi, com base no grau de cicatrização. Os testes X2, Wilcoxon e o cálculo da razão de chances foram utilizados na análise estatística com nível de significância de 5%. Resultados: A extremidade proximal da tíbia foi o local mais frequente (17,0%). Trinta e três (70,3%) COA eram B3 e 28 (59,7%) do tipo II. O número médio de injeções aplicadas foi de 2,8 por paciente, com redução média da área lítica inicial de 83,7% (p = 0,00001). Resultados satisfatórios para 91,4% (n = 43; p = 0,00001) dos pacientes e houve cinco recidivas. Nenhum efeito colateral foi observado. Conclusão: A injeção intralesional percutânea de calcitonina e metilprednisolona é um método minimamente invasivo, eficaz e seguro para promover a ossificação do COA. Nível de evidência IV, Tipo de estudo: série de casos.

Type of Medium: Online Resource

ISSN: 1809-4406 , 1413-7852

URL: Article

DOI: 10.1590/1413-785220182605201423

Language: Unknown

Publisher: FapUNIFESP (SciELO)

Publication Date: 2018

detail.hit.zdb_id: 2105206-2

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6

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PATHOLOGICAL FRACTURES DUE TO BONE METASTASES FROM LUNG CANCER: RISK FACTORS AND SURVIVAL

Oliveira, Marcelo Bragança dos Reis ; Marques, Bruno de Carvalho ; Matos, Rosa Aurílio ; [et al.]

FapUNIFESP (SciELO) ; 2018

In: Acta Ortopédica Brasileira Vol. 26, No. 6 ( 2018-12), p. 388-393

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In: Acta Ortopédica Brasileira, FapUNIFESP (SciELO), Vol. 26, No. 6 ( 2018-12), p. 388-393

Abstract: RESUMO Introdução: Fratura patológica é um evento esquelético frequente em pacientes com câncer de pulmão, resultando em alta morbidade e sobrevida global reduzida que torna a decisão de tratamento cirúrgico desafiadora. Objetivos: Identificar fatores de risco associados à ocorrência de fraturas patológicas em pacientes com câncer de pulmão e determinar a sobrevida. Métodos: Conduzimos um estudo retrospectivo de coorte com 407 pacientes diagnosticados com carcinoma pulmonar entre 2006 e 2015. A prevalência de metástase óssea e fratura patológica foi calculada. Análise estatística foi conduzida usando o teste X2, e razão de chances e o intervalo de confiança de 95% foi calculado. A sobrevida global foi determinada usando o método de Kaplan-Meier e as diferenças foram comparadas usando o teste do log-rank. Resultados: A prevalência de metástases ósseas e fraturas patológicas foi de 28,2% (n = 115) e 19,1% (n = 22), respectivamente. Fraturas patológicas foram mais frequentes em pacientes com metástases ósseas ao diagnóstico do câncer de pulmão (24,7 % [n = 20] vs. 5,9% [n = 2] ; p 〈 0.05). A sobrevida global média após o diagnóstico do câncer de pulmão, da metástase óssea e da fratura patológica foram 6, 4 e 2 meses, respectivamente. Conclusão: Fratura patológica foi associada à metástase óssea sincrônica e a sobrevida global consideravelmente reduzida. Nível de Evidência IV. Série de Casos.

Type of Medium: Online Resource

ISSN: 1809-4406 , 1413-7852

URL: Article

DOI: 10.1590/1413-785220182606201669

Language: English

Publisher: FapUNIFESP (SciELO)

Publication Date: 2018

detail.hit.zdb_id: 2105206-2

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7

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O impacto da histologia do carcinoma pulmonar na frequência das metástases ósseas

Oliveira, Marcelo Bragança dos Reis ; Souza, Larissa Costa ; Sampayo, Ermides Javier Garcia ; [et al.]

Georg Thieme Verlag KG ; 2019

In: Revista Brasileira de Ortopedia Vol. 54, No. 05 ( 2019-09), p. 524-530

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In: Revista Brasileira de Ortopedia, Georg Thieme Verlag KG, Vol. 54, No. 05 ( 2019-09), p. 524-530

Abstract: Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using chi-squared tests, odds ratios (ORs) and 95% confidence intervals (CIs). The overall survival was evaluated using the Kaplan-Meier method. Results The prevalence of bone metastases was 28.2% (n = 115), and the spine was the most frequently affected site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and it was significantly more frequent among patients with bone metastases (58.3% versus 42.1%; p = 0.003; OR = 1.92; 95% CI: 1.29–2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% versus 29.8%; p = 0.0004; OR = 0.35; 95% CI: 0.19–0.64). The median survival time after the first bone metastasis diagnosis was 4 months. Conclusion Adenocarcinoma was the most common histological subtype of lung carcinoma, and it was significantly associated with a higher risk of developing bone metastases.

Type of Medium: Online Resource

ISSN: 0102-3616 , 1982-4378

URL: Article

DOI: 10.1016/j.rbo.2018.02.002

Language: Portuguese

Publisher: Georg Thieme Verlag KG

Publication Date: 2019

detail.hit.zdb_id: 2411301-3

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8

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In-hospital mortality and severe outcomes after hospital discharge due to COVID-19: A prospective multicenter study from Brazil

Perazzo, Hugo ; Cardoso, Sandra W. ; Ribeiro, Maria Pia D. ; [et al.]

Elsevier BV ; 2022

In: The Lancet Regional Health - Americas Vol. 11 ( 2022-07), p. 100244-

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In: The Lancet Regional Health - Americas, Elsevier BV, Vol. 11 ( 2022-07), p. 100244-

Type of Medium: Online Resource

ISSN: 2667-193X

URL: Article

DOI: 10.1016/j.lana.2022.100244

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 3096925-6

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Evaluation of Gamma Interferon Immune Response Elicited by the Newly Constructed PstS-1(285-374):CFP10 Fusion Protein To Detect Mycobacterium tuberculosis Infection

Araujo, Leonardo Silva de ; Mello, Fernanda Carvalho de Queiroz ; da Silva, Nidai de Bárbara Moreira ; [et al.]

American Society for Microbiology ; 2014

In: Clinical and Vaccine Immunology Vol. 21, No. 4 ( 2014-04), p. 552-560

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In: Clinical and Vaccine Immunology, American Society for Microbiology, Vol. 21, No. 4 ( 2014-04), p. 552-560

Abstract: The PstS1 antigen is highly immunogenic, principally when combined with CFP10 during both latent and active TB infection. In the present study, a selected pstS1 gene fragment was cloned, fused with CFP10, and expressed in Escherichia coli . The product [PstS-1(285-374):CFP10] was compared to the recombinant fused RD1 (region of deletion 1) protein (ESAT-6:CFP10) in detecting Mycobacterium tuberculosis infection in 108 recent contacts of pulmonary tuberculosis (TB) cases, considering a positive tuberculin skin test (TST) to be the baseline. The release of gamma interferon (IFN-γ) in 22-h whole-blood and 5-day lymphocyte stimulation assays primed with each antigen was determined. All contacts were clinically followed for up to 1 year, and 87% of the tuberculin skin test-positive (TST positive ) patients accepted preventative treatment. Concerning the IFN-γ response to PstS-1(285-374):CFP10 in the 22-h and 5-day assays, a slight increase in contact-TST positive detection was observed (23/54 and 26/54) compared to the level seen with the RD1 protein (18/54 and 24/54) whereas in the TST negative group, similarly lower numbers (≤5/48) of responders were achieved for both antigens, except for RD1 in the 5-day assay (8/48). By combining the IFN-γ responders to both antigens in the 5-day assays, slightly higher increases in positivity were found in the TST positive (32/54) and TST negative (10/48) groups. Two of 12 untreated TST positive contacts progressed to active TB and were concordantly positive in all assays, except for one contact who lacked positivity in the RD1 5-day assay. We demonstrated for the first time that PstS-1(285-374):CFP10 slightly increased contact positivity and detection of active disease progression, suggesting its potential application as a TB infection marker.

Type of Medium: Online Resource

ISSN: 1556-6811 , 1556-679X

URL: Article

DOI: 10.1128/CVI.00726-13

Language: English

Publisher: American Society for Microbiology

Publication Date: 2014

detail.hit.zdb_id: 1496863-0

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10

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III Diretrizes para Tuberculose da Sociedade Brasileira de Pneumologia e Tisiologia

Conde, Marcus Barreto ; Melo, Fernando Augusto Fiuza de ; Marques, Ana Maria Campos ; [et al.]

FapUNIFESP (SciELO) ; 2009

In: Jornal Brasileiro de Pneumologia Vol. 35, No. 10 ( 2009-10), p. 1018-1048

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In: Jornal Brasileiro de Pneumologia, FapUNIFESP (SciELO), Vol. 35, No. 10 ( 2009-10), p. 1018-1048

Abstract: New scientific articles about tuberculosis (TB) are published daily worldwide. However, it is difficult for health care workers, overloaded with work, to stay abreast of the latest research findings and to discern which information can and should be used in their daily practice on assisting TB patients. The purpose of the III Brazilian Thoracic Association (BTA) Guidelines on TB is to critically review the most recent national and international scientific information on TB, presenting an updated text with the most current and useful tools against TB to health care workers in our country. The III BTA Guidelines on TB have been developed by the BTA Committee on TB and the TB Work Group, based on the text of the II BTA Guidelines on TB (2004). We reviewed the following databases: LILACS (SciELO) and PubMed (Medline). The level of evidence of the cited articles was determined, and 24 recommendations on TB have been evaluated, discussed by all of the members of the BTA Committee on TB and of the TB Work Group, and highlighted. The first version of the present Guidelines was posted on the BTA website and was available for public consultation for three weeks. Comments and critiques were evaluated. The level of scientific evidence of each reference was evaluated before its acceptance for use in the final text.

Type of Medium: Online Resource

ISSN: 1806-3713

URL: Article

DOI: 10.1590/S1806-37132009001000011

Language: Unknown

Publisher: FapUNIFESP (SciELO)

Publication Date: 2009

detail.hit.zdb_id: 2223157-2

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Kooperativer Bibliotheksverbund

Berlin Brandenburg