KOBV Portal

Hits per page

hits 1 - 10 | 548 hits

Sorting

Online Resource

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

Melton, Alexandra ; Doyle-Meyers, Lara A. ; Blair, Robert V. ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 12 ( 2021-12-20), p. e1010162-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2021-12-20), p. e1010162-

Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections rising again due to the emergence of highly transmissible variants. Animal models that faithfully recapitulate human disease are critical for assessing SARS-CoV-2 viral and immune dynamics, for understanding mechanisms of disease, and for testing vaccines and therapeutics. Pigtail macaques (PTM, Macaca nemestrina ) demonstrate a rapid and severe disease course when infected with simian immunodeficiency virus (SIV), including the development of severe cardiovascular symptoms that are pertinent to COVID-19 manifestations in humans. We thus proposed this species may likewise exhibit severe COVID-19 disease upon infection with SARS-CoV-2. Here, we extensively studied a cohort of SARS-CoV-2-infected PTM euthanized either 6- or 21-days after respiratory viral challenge. We show that PTM demonstrate largely mild-to-moderate COVID-19 disease. Pulmonary infiltrates were dominated by T cells, including CD4+ T cells that upregulate CD8 and express cytotoxic molecules, as well as virus-targeting T cells that were predominantly CD4+. We also noted increases in inflammatory and coagulation markers in blood, pulmonary pathologic lesions, and the development of neutralizing antibodies. Together, our data demonstrate that SARS-CoV-2 infection of PTM recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1010162

DOI: 10.1371/journal.ppat.1010162.g001

DOI: 10.1371/journal.ppat.1010162.g002

DOI: 10.1371/journal.ppat.1010162.g003

DOI: 10.1371/journal.ppat.1010162.g004

DOI: 10.1371/journal.ppat.1010162.g005

DOI: 10.1371/journal.ppat.1010162.g006

DOI: 10.1371/journal.ppat.1010162.g007

DOI: 10.1371/journal.ppat.1010162.g008

DOI: 10.1371/journal.ppat.1010162.g009

DOI: 10.1371/journal.ppat.1010162.g010

DOI: 10.1371/journal.ppat.1010162.g011

DOI: 10.1371/journal.ppat.1010162.t001

DOI: 10.1371/journal.ppat.1010162.s001

DOI: 10.1371/journal.ppat.1010162.s002

DOI: 10.1371/journal.ppat.1010162.s003

DOI: 10.1371/journal.ppat.1010162.s004

DOI: 10.1371/journal.ppat.1010162.s005

DOI: 10.1371/journal.ppat.1010162.s006

DOI: 10.1371/journal.ppat.1010162.s007

DOI: 10.1371/journal.ppat.1010162.s008

DOI: 10.1371/journal.ppat.1010162.s009

DOI: 10.1371/journal.ppat.1010162.s010

DOI: 10.1371/journal.ppat.1010162.s011

DOI: 10.1371/journal.ppat.1010162.s012

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Consensus Summary on the Diagnosis and Treatment of Osteoporosis

Andersson, Gunnar B. J. ; Bostrom, Mathias P. G. ; Eyre, David R. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 1997

In: Spine Vol. 22, No. Supplement ( 1997-12), p. 63S-65S

add to watchlist on the watchlist

Details

In: Spine, Ovid Technologies (Wolters Kluwer Health), Vol. 22, No. Supplement ( 1997-12), p. 63S-65S

Type of Medium: Online Resource

ISSN: 0362-2436

URL: Article

DOI: 10.1097/00007632-199712151-00011

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 1997

detail.hit.zdb_id: 2002195-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Exploring Celiac Disease Outcomes in the Community: Melting the Celiac Iceberg?: 2010 ACG Auxiliary Award : 210

Rubio-Tapia, Alberto ; Brantner, Tricia ; Lahr, Brian ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2010

In: American Journal of Gastroenterology Vol. 105 ( 2010-10), p. S79-

add to watchlist on the watchlist

Details

In: American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 105 ( 2010-10), p. S79-

Type of Medium: Online Resource

ISSN: 0002-9270

URL: Article

DOI: 10.14309/00000434-201010001-00210

RVK:

XA 18920

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2010

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Merid, Simon Kebede ; Novoloaca, Alexei ; Sharp, Gemma C. ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Genome Medicine Vol. 12, No. 1 ( 2020-12)

add to watchlist on the watchlist

Details

In: Genome Medicine, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2020-12)

Abstract: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P 〈 1.06 × 10 − 7 , of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.

Type of Medium: Online Resource

ISSN: 1756-994X

URL: Article

DOI: 10.1186/s13073-020-0716-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2484394-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Increasing Incidence of Celiac Disease in a North American Population

Ludvigsson, Jonas F ; Rubio-Tapia, Alberto ; van Dyke, Carol T ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2013

In: American Journal of Gastroenterology Vol. 108, No. 5 ( 2013-05), p. 818-824

add to watchlist on the watchlist

Details

In: American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 108, No. 5 ( 2013-05), p. 818-824

Type of Medium: Online Resource

ISSN: 0002-9270

URL: Article

DOI: 10.1038/ajg.2013.60

RVK:

XA 18920

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2013

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Sharp, Gemma C ; Salas, Lucas A ; Monnereau, Claire ; [et al.]

Oxford University Press (OUP) ; 2017

In: Human Molecular Genetics Vol. 26, No. 20 ( 2017-10-15), p. 4067-4085

add to watchlist on the watchlist

Details

In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 26, No. 20 ( 2017-10-15), p. 4067-4085

Type of Medium: Online Resource

ISSN: 0964-6906 , 1460-2083

URL: Article

DOI: 10.1093/hmg/ddx290

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2017

detail.hit.zdb_id: 1474816-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Screening for Celiac Disease in a North American Population: Sequential Serology and Gastrointestinal Symptoms

Katz, Kent D ; Rashtak, Shahrooz ; Lahr, Brian D ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2011

In: American Journal of Gastroenterology Vol. 106, No. 7 ( 2011-07), p. 1333-1339

add to watchlist on the watchlist

Details

In: American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 106, No. 7 ( 2011-07), p. 1333-1339

Type of Medium: Online Resource

ISSN: 0002-9270

URL: Article

DOI: 10.1038/ajg.2011.21

RVK:

XA 18920

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2011

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Felix, Janine F ; Joubert, Bonnie R ; Baccarelli, Andrea A ; [et al.]

Oxford University Press (OUP) ; 2018

In: International Journal of Epidemiology Vol. 47, No. 1 ( 2018-02-01), p. 22-23u

add to watchlist on the watchlist

Details

In: International Journal of Epidemiology, Oxford University Press (OUP), Vol. 47, No. 1 ( 2018-02-01), p. 22-23u

Type of Medium: Online Resource

ISSN: 0300-5771 , 1464-3685

URL: Article

DOI: 10.1093/ije/dyx190

RVK:

XF 4100

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2018

detail.hit.zdb_id: 1494592-7

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A Comparison of The Rome and Manning Criteria for Case Identification in Epidemiological Investigations of Irritable Bowel Syndrome

Saito, Yuri Ann ; Locke, Richard G ; Talley, Nicholas J ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2000

In: American Journal of Gastroenterology Vol. 95, No. 10 ( 2000-10), p. 2816-2824

add to watchlist on the watchlist

Details

In: American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 10 ( 2000-10), p. 2816-2824

Type of Medium: Online Resource

ISSN: 0002-9270

URL: Article

DOI: 10.1111/j.1572-0241.2000.03192.x

RVK:

XA 18920

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2000

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohnʼs disease and ulcerative colitis

Tung, Jeanne ; Loftus, Edward V. ; Freese, Deborah K. ; [et al.]

Oxford University Press (OUP) ; 2006

In: Inflammatory Bowel Diseases Vol. 12, No. 12 ( 2006-12), p. 1093-1100

add to watchlist on the watchlist

Details

In: Inflammatory Bowel Diseases, Oxford University Press (OUP), Vol. 12, No. 12 ( 2006-12), p. 1093-1100

Type of Medium: Online Resource

ISSN: 1078-0998

URL: Article

DOI: 10.1097/01.mib.0000235835.32176.85

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2006

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 548 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg