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Tumor-Derived Mutated E-Cadherin Influences β -Catenin Localization and Increases Susceptibility to Actin Cytoskeletal Changes Induced by Pervanadate

Luber, Birgit ; Candidus, Sonja ; Handschuh, Gabriele ; [et al.]

Informa UK Limited ; 2000

In: Cell Adhesion and Communication Vol. 7, No. 5 ( 2000-01), p. 391-408

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In: Cell Adhesion and Communication, Informa UK Limited, Vol. 7, No. 5 ( 2000-01), p. 391-408

Type of Medium: Online Resource

ISSN: 1029-2314

URL: Article

DOI: 10.3109/15419060009109021

Language: English

Publisher: Informa UK Limited

Publication Date: 2000

detail.hit.zdb_id: 2486523-0

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CHD4/Mi-2β activity is required for the positioning of the mesoderm/neuroectoderm boundary in Xenopus

Linder, Britta ; Mentele, Edith ; Mansperger, Katrin ; [et al.]

Cold Spring Harbor Laboratory ; 2007

In: Genes & Development Vol. 21, No. 8 ( 2007-04-15), p. 973-983

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In: Genes & Development, Cold Spring Harbor Laboratory, Vol. 21, No. 8 ( 2007-04-15), p. 973-983

Abstract: Experiments in Xenopus have illustrated the importance of extracellular morphogens for embryonic gene regulation in vertebrates. Much less is known about how induction leads to the correct positioning of boundaries; for example, between germ layers. Here we report that the neuroectoderm/mesoderm boundary is controlled by the chromatin remodeling ATPase CHD4/Mi-2β. Gain and loss of CHD4 function experiments shifted this boundary along the animal–vegetal axis at gastrulation, leading to excess mesoderm formation at the expense of neuroectoderm, or vice versa. This phenotype results from specific alterations in gene transcription, notably of the neural-promoting gene Sip1 and the mesodermal regulatory gene Xbra . We show that CHD4 suppresses Sip1 transcription by direct binding to the 5′ end of the Sip1 gene body. Furthermore, we demonstrate that CHD4 and Sip1 expression levels determine the “ON” threshold for Nodal-dependent but not for eFGF-dependent induction of Xbra transcription. The CHD4/Sip1 epistasis thus constitutes a regulatory module, which balances mesoderm and neuroectoderm formation.

Type of Medium: Online Resource

ISSN: 0890-9369 , 1549-5477

URL: Article

DOI: 10.1101/gad.409507

RVK:

WA 15000

Language: English

Publisher: Cold Spring Harbor Laboratory

Publication Date: 2007

detail.hit.zdb_id: 1467414-2

SSG: 12

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Stage-Specific Histone Modification Profiles Reveal Global Transitions in the Xenopus Embryonic Epigenome

Schneider, Tobias D. ; Arteaga-Salas, Jose M. ; Mentele, Edith ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS ONE Vol. 6, No. 7 ( 2011-7-22), p. e22548-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 7 ( 2011-7-22), p. e22548-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0022548

DOI: 10.1371/journal.pone.0022548.g001

DOI: 10.1371/journal.pone.0022548.g002

DOI: 10.1371/journal.pone.0022548.g003

DOI: 10.1371/journal.pone.0022548.g004

DOI: 10.1371/journal.pone.0022548.g005

DOI: 10.1371/journal.pone.0022548.g006

DOI: 10.1371/journal.pone.0022548.s001

DOI: 10.1371/journal.pone.0022548.s002

DOI: 10.1371/journal.pone.0022548.s003

DOI: 10.1371/journal.pone.0022548.s004

DOI: 10.1371/journal.pone.0022548.s005

DOI: 10.1371/journal.pone.0022548.s006

DOI: 10.1371/journal.pone.0022548.s007

DOI: 10.1371/journal.pone.0022548.s008

DOI: 10.1371/journal.pone.0022548.s009

DOI: 10.1371/journal.pone.0022548.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2267670-3

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The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus

Angerilli, Alessandro ; Tait, Janet ; Berges, Julian ; [et al.]

Life Science Alliance, LLC ; 2023

In: Life Science Alliance Vol. 6, No. 7 ( 2023-07), p. e202302023-

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In: Life Science Alliance, Life Science Alliance, LLC, Vol. 6, No. 7 ( 2023-07), p. e202302023-

Abstract: H4 lysine 20 dimethylation (H4K20me2) is the most abundant histone modification in vertebrate chromatin. It arises from sequential methylation of unmodified histone H4 proteins by the mono-methylating enzyme PR-SET7/KMT5A, followed by conversion to the dimethylated state by SUV4-20H (KMT5B/C) enzymes. We have blocked the deposition of this mark by depleting Xenopus embryos of SUV4-20H1/H2 methyltransferases. In the larval epidermis, this results in a severe loss of cilia in multiciliated cells (MCC), a key component of mucociliary epithelia. MCC precursor cells are correctly specified, amplify centrioles, but ultimately fail in ciliogenesis because of the perturbation of cytoplasmic processes. Genome-wide transcriptome profiling reveals that SUV4-20H1/H2-depleted ectodermal explants preferentially down-regulate the expression of several hundred ciliogenic genes. Further analysis demonstrated that knockdown of SUV4-20H1 alone is sufficient to generate the MCC phenotype and that its catalytic activity is needed for axoneme formation. Overexpression of the H4K20me1-specific histone demethylase PHF8/KDM7B also rescues the ciliogenic defect in a significant manner. Taken together, this indicates that the conversion of H4K20me1 to H4K20me2 by SUV4-20H1 is critical for the formation of cilia tufts.

Type of Medium: Online Resource

ISSN: 2575-1077

URL: Article

DOI: 10.26508/lsa.202302023

Language: English

Publisher: Life Science Alliance, LLC

Publication Date: 2023

detail.hit.zdb_id: 2948687-7

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Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation

Pünzeler, Sebastian ; Link, Stephanie ; Wagner, Gabriele ; [et al.]

EMBO ; 2017

In: The EMBO Journal Vol. 36, No. 15 ( 2017-08), p. 2263-2279

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In: The EMBO Journal, EMBO, Vol. 36, No. 15 ( 2017-08), p. 2263-2279

Abstract: image PWWP2A, a novel multivalent H2A.Z‐nucleosome binder, regulates mitotic progression in human cells and cranial facial morphogenesis during frog development, thereby providing a possible link between H2A.Z, chromosome segregation and organ development. Histone H2A.Z interactome analyses identify PWWP2A as novel H2A.Z‐nucleosome binder. Distinct regions in PWWP2A mediate nucleosome binding, H2A.Z specificity, and direct DNA interaction. PWWP2A localizes to H2A.Z‐containing nucleosomes at transcriptional start sites of highly transcribed genes. Depletion of PWWP2A in human cells results in changed gene expression profiles and severe mitotic defects without affecting H2A.Z occupancy. PWWP2A loss during frog development affects proper neural crest stem cell differentiation and migration, causing severe cranial‐facial defects.

Type of Medium: Online Resource

ISSN: 0261-4189 , 1460-2075

URL: Article

DOI: 10.15252/embj.201695757

RVK:

WA 15000

Language: English

Publisher: EMBO

Publication Date: 2017

detail.hit.zdb_id: 1467419-1

detail.hit.zdb_id: 586044-1

SSG: 12

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