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Minor defects of the luminal integrity in arterial introducer eSheaths after transcatheter aortic valve implantation

Buege, Michael ; Koehler, Till ; Heiderhoff, Ralf ; [weitere]

Public Library of Science (PLoS) ; 2017

In: PLOS ONE Vol. 12, No. 5 ( 2017-5-8), p. e0176893-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 12, No. 5 ( 2017-5-8), p. e0176893-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0176893

DOI: 10.1371/journal.pone.0176893.g001

DOI: 10.1371/journal.pone.0176893.g002

DOI: 10.1371/journal.pone.0176893.g003

DOI: 10.1371/journal.pone.0176893.g004

DOI: 10.1371/journal.pone.0176893.g005

DOI: 10.1371/journal.pone.0176893.g006

DOI: 10.1371/journal.pone.0176893.t001

DOI: 10.1371/journal.pone.0176893.s001

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2017

ZDB Id: 2267670-3

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Acute myocardial injury secondary to severe acute liver failure: A retrospective analysis supported by animal data

Uhlig, Moritz ; Hein, Marc ; Habigt, Moriz A. ; [weitere]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 8 ( 2021-8-30), p. e0256790-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-30), p. e0256790-

Kurzfassung: To investigate whether acute liver failure (ALF) leads to secondary acute myocardial injury, 100 ALF patients that were retrospectively identified in a single center based on ICD 10 codes and 8 rats from an experimental study that died early after bile duct ligation (BDL) were examined. Creatine kinase (CK), creatine kinase-MB isoenzyme (CKMB) and cardiac troponin-I (cTnI) were analyzed as markers of myocardial injury. For histological analysis, hematoxylin-eosin (HE), elastic Van Gieson (EVG), CD41 and myeloperoxidase were used to stain rat hearts. Major adverse cardiac events (MACEs) were a critical factor for mortality (p = 0.037) in human ALF. Deceased patients exhibited higher levels of CKMB than survivors (p = 0.023). CKMB was a predictor of mortality in ALF (p = 0.013). Animals that died early after BDL exhibited increased cTnI, CKMB, tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) levels compared to controls (cTnI: p = 0.011, CKMB: p = 0.008, TNFα: p = 0.003, IL-6: p = 0.006). These animals showed perivascular lesions and wavy fibers, microthrombi and neutrophilic infiltration in the heart. MACEs are decisive for mortality in human ALF, and elevated CKMB values indicate that this might be due to structural myocardial damage. Accordingly, CKMB was found to have predictive value for mortality in ALF. The results are substantiated by data from a rat BDL model demonstrating diffuse myocardial injury.

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0256790

DOI: 10.1371/journal.pone.0256790.g001

DOI: 10.1371/journal.pone.0256790.g002

DOI: 10.1371/journal.pone.0256790.g003

DOI: 10.1371/journal.pone.0256790.g004

DOI: 10.1371/journal.pone.0256790.g005

DOI: 10.1371/journal.pone.0256790.t001

DOI: 10.1371/journal.pone.0256790.t002

DOI: 10.1371/journal.pone.0256790.t003

DOI: 10.1371/journal.pone.0256790.s001

DOI: 10.1371/journal.pone.0256790.s002

DOI: 10.1371/journal.pone.0256790.s003

DOI: 10.1371/journal.pone.0256790.s004

DOI: 10.1371/journal.pone.0256790.s005

DOI: 10.1371/journal.pone.0256790.s006

DOI: 10.1371/journal.pone.0256790.s007

DOI: 10.1371/journal.pone.0256790.s008

DOI: 10.1371/journal.pone.0256790.s009

DOI: 10.1371/journal.pone.0256790.s010

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2021

ZDB Id: 2267670-3

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The modified MIDA-Score predicts mid-term outcomes after interventional therapy of functional mitral regurgitation

Öztürk, Can ; Becher, Marc Ulrich ; Kalkan, Alev ; [weitere]

Public Library of Science (PLoS) ; 2020

In: PLOS ONE Vol. 15, No. 7 ( 2020-7-22), p. e0236265-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 7 ( 2020-7-22), p. e0236265-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0236265

DOI: 10.1371/journal.pone.0236265.g001

DOI: 10.1371/journal.pone.0236265.g002

DOI: 10.1371/journal.pone.0236265.g003

DOI: 10.1371/journal.pone.0236265.g004

DOI: 10.1371/journal.pone.0236265.g005

DOI: 10.1371/journal.pone.0236265.g006

DOI: 10.1371/journal.pone.0236265.t001

DOI: 10.1371/journal.pone.0236265.t002

DOI: 10.1371/journal.pone.0236265.t003

DOI: 10.1371/journal.pone.0236265.t004

DOI: 10.1371/journal.pone.0236265.t005

DOI: 10.1371/journal.pone.0236265.t006

DOI: 10.1371/journal.pone.0236265.t007

DOI: 10.1371/journal.pone.0236265.s001

DOI: 10.1371/journal.pone.0236265.s002

DOI: 10.1371/journal.pone.0236265.s003

DOI: 10.1371/journal.pone.0236265.s004

DOI: 10.1371/journal.pone.0236265.s005

DOI: 10.1371/journal.pone.0236265.r001

DOI: 10.1371/journal.pone.0236265.r002

DOI: 10.1371/journal.pone.0236265.r003

DOI: 10.1371/journal.pone.0236265.r004

DOI: 10.1371/journal.pone.0236265.r005

DOI: 10.1371/journal.pone.0236265.r006

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2020

ZDB Id: 2267670-3

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Increases in Myocardial Workload Induced by Rapid Atrial Pacing Trigger Alterations in Global Metabolism

Turer, Aslan T. ; Lewis, Gregory D. ; O'Sullivan, John F. ; [weitere]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 6 ( 2014-6-16), p. e99058-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 6 ( 2014-6-16), p. e99058-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0099058

DOI: 10.1371/journal.pone.0099058.g001

DOI: 10.1371/journal.pone.0099058.g002

DOI: 10.1371/journal.pone.0099058.g003

DOI: 10.1371/journal.pone.0099058.g004

DOI: 10.1371/journal.pone.0099058.t001

DOI: 10.1371/journal.pone.0099058.t002

DOI: 10.1371/journal.pone.0099058.t003

DOI: 10.1371/journal.pone.0099058.s001

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2014

ZDB Id: 2267670-3

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Long-term impact of a bonus freeze on clinical outcome: Analysis of effective and non-effective bonus freezes in cryoballoon ablation

Koektuerk, Buelent ; Koektuerk, Oezlem ; Yorgun, Hikmet ; [weitere]

Public Library of Science (PLoS) ; 2019

In: PLOS ONE Vol. 14, No. 5 ( 2019-5-3), p. e0214231-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 14, No. 5 ( 2019-5-3), p. e0214231-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0214231

DOI: 10.1371/journal.pone.0214231.g001

DOI: 10.1371/journal.pone.0214231.g002

DOI: 10.1371/journal.pone.0214231.g003

DOI: 10.1371/journal.pone.0214231.t001

DOI: 10.1371/journal.pone.0214231.t002

DOI: 10.1371/journal.pone.0214231.t003

DOI: 10.1371/journal.pone.0214231.t004

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2019

ZDB Id: 2267670-3

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Valve-in-Valve Implantation of Medtronic CoreValve Prosthesis in Patients with Failing Bioprosthetic Aortic Valves

Linke, Axel ; Woitek, Felix ; Merx, Marc W. ; [weitere]

Ovid Technologies (Wolters Kluwer Health) ; 2012

In: Circulation: Cardiovascular Interventions Vol. 5, No. 5 ( 2012-10), p. 689-697

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In: Circulation: Cardiovascular Interventions, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 5 ( 2012-10), p. 689-697

Kurzfassung: Transcatheter aortic valve implantation (TAVI) using the Medtronic CoreValve (MCV) system might represent an alternative to conventional redo surgery in older high-risk patients with a failing aortic valve bioprosthesis. Methods and Results— Symptomatic patients with failing aortic valve bioprosthesis, aged ≥65 years with a logistic EuroSCORE ≥10 % were considered for treatment. Local anesthesia was used to retrogradely implant the MCV system into the failing bioprosthetic valve. Clinical events were recorded and a transthoracic echocardiography was performed to evaluate the impact of MCV on hemodynamics after transcatheter aortic valve implantation. A total of 27 patients (aged 74.8±8 years, logistic EuroSCORE of 31±17%) were treated. In those with AS and AS and AR (n=25), the mean gradient declined from 42±16 mm Hg before to 18±8 mm Hg after MCV implantation ( P 〈 0.001), in those with AR the level declined by 2. There was no intraprocedural death and no procedural myocardial infarction. On the basis of the definitions of the Valvular Academic Research Consortium, the rate of major stroke was 7.4 %, of life-threatening bleeding 7.4%, of kidney failure stage III 7.4%, and of major access site complication 11.1 %, respectively. Within 30 days after the procedure, 2 patients died; 1 from stroke and 1 from cardiac failure (30-day mortality: 7.4%). Conclusions— These results suggest that transfemoral MCV implantation into a wide range of degenerated aortic bioprosthetic valves—irrespective of the failure mode—is feasible, safe, and improves hemodynamics in older patients with higher risk for conventional aortic valve redo surgery.

Materialart: Online-Ressource

ISSN: 1941-7640 , 1941-7632

URL: Article

DOI: 10.1161/CIRCINTERVENTIONS.112.972331

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2012

ZDB Id: 2450801-9

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Cardiac-Specific Overexpression of Inducible Nitric Oxide Synthase Does Not Result in Severe Cardiac Dysfunction

Heger, Jacqueline ; Gödecke, Axel ; Flögel, Ulrich ; [weitere]

Ovid Technologies (Wolters Kluwer Health) ; 2002

In: Circulation Research Vol. 90, No. 1 ( 2002-01-11), p. 93-99

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In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 90, No. 1 ( 2002-01-11), p. 93-99

Kurzfassung: Nitric oxide (NO), a potent regulator of myocardial contractility, has been implicated in the development of heart failure; however, no study exists describing the relation between expression of inducible nitric oxide synthase (iNOS), formation of NO in vivo, and cardiac contractility. We have therefore generated transgenic (TG) mice overexpressing iNOS under the cardiospecific α-myosin heavy chain (α-MHC) promoter. In vitro, iNOS activity in hearts of two transgenic lines was 260- to 400-fold above controls (wild type [WT]), but TG mice were viable and appeared normal. Ventricular mass/body weight ratio did not differ; heart rate and cardiac output as well as mean arterial blood pressure were decreased by 10%. NO x levels of hearts and blood of TG mice were 2.5- and 2-fold above WT controls, respectively. In the isolated heart, release of the NO oxidation products nitrate and nitrite, an index of in vivo NOS activity, was 40-fold over WT. However, cardiac hemodynamics and levels of ATP and phosphocreatine were unaltered. The high iNOS activity was associated with reduced cardiac l -arginine in TG hearts to only 15% of the WT, indicating limited substrate availability, whereas l -citrulline was 20-fold elevated. Our findings demonstrate that the heart can tolerate high levels of iNOS activity without detrimental functional consequences. The concept that iNOS-derived NO is the triggering factor in the pathomechanism leading to heart failure therefore needs to be reevaluated.

Materialart: Online-Ressource

ISSN: 0009-7330 , 1524-4571

URL: Article

DOI: 10.1161/hh0102.102757

RVK:

XA 10000

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2002

ZDB Id: 1467838-X

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Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation

Weferling, Maren ; Liebetrau, Christoph ; Renker, Matthias ; [weitere]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 6 ( 2021-6-16), p. e0253332-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 6 ( 2021-6-16), p. e0253332-

Kurzfassung: Transcatheter aortic valve implantation (TAVI) is the standard treatment option for patients with severe aortic stenosis (AS) at intermediate or high surgical risk. Preexisting right bundle branch block (RBBB) is a strong predictor of new pacemaker implantation (PPM) after TAVI, and previous data indicate a worse short- and long-term outcome of patients. The aim of this study was to investigate whether preexisting RBBB has an effect on the short- and mid-term outcome of patients undergoing TAVI in a German high-volume TAVI center. Methods For the present retrospective analysis, a total of 1,891 patients with native severe AS with successful TAVI without preexisting PPM were included. The primary endpoint was all-cause mortality after 30 days and 12 months. Baseline RBBB was present in 190 (10.1%) of cases. Results Patients with preexisting RBBB had a considerably higher rate of new PPM after TAVI compared with patients without RBBB (87/190 [45.8%] vs. 219/1,701 [12.9%] ; p 〈 0.001). RBBB had no impact on all-cause mortality at 30 days (2.1% vs. 2.7%; p = 0.625) and at 12 months (14.4% vs. 13.6%; p = 0.765). Further stratification according to the presence of new PPM showed a difference in mid-term survival rates between the four groups, with the worst outcome for patients without RBBB and new PPM (log rank p = 0.024). However, no difference in mid-term cardiovascular survival was found. Conclusion Preexisting RBBB is a common finding in patients with severe AS undergoing TAVI and is associated with considerably higher PPM rates but not with worse short- and mid-term outcome.

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0253332

DOI: 10.1371/journal.pone.0253332.g001

DOI: 10.1371/journal.pone.0253332.g002

DOI: 10.1371/journal.pone.0253332.g003

DOI: 10.1371/journal.pone.0253332.g004

DOI: 10.1371/journal.pone.0253332.t001

DOI: 10.1371/journal.pone.0253332.t002

DOI: 10.1371/journal.pone.0253332.t003

DOI: 10.1371/journal.pone.0253332.s001

DOI: 10.1371/journal.pone.0253332.s002

DOI: 10.1371/journal.pone.0253332.s003

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2021

ZDB Id: 2267670-3

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Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension

Kriechbaum, Steffen D. ; Wiedenroth, Christoph B. ; Keller, Till ; [weitere]

Public Library of Science (PLoS) ; 2018

In: PLOS ONE Vol. 13, No. 9 ( 2018-9-25), p. e0204683-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 13, No. 9 ( 2018-9-25), p. e0204683-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0204683

DOI: 10.1371/journal.pone.0204683.g001

DOI: 10.1371/journal.pone.0204683.t001

DOI: 10.1371/journal.pone.0204683.t002

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2018

ZDB Id: 2267670-3

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Circulating NOS3 Modulates Left Ventricular Remodeling following Reperfused Myocardial Infarction

Gorressen, Simone ; Stern, Manuel ; van de Sandt, Annette M. ; [weitere]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 4 ( 2015-4-14), p. e0120961-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 4 ( 2015-4-14), p. e0120961-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0120961

DOI: 10.1371/journal.pone.0120961.g001

DOI: 10.1371/journal.pone.0120961.g002

DOI: 10.1371/journal.pone.0120961.g003

DOI: 10.1371/journal.pone.0120961.t001

DOI: 10.1371/journal.pone.0120961.t002

DOI: 10.1371/journal.pone.0120961.s001

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2015

ZDB Id: 2267670-3

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