In:
Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-1-26)
Abstract:
Alzheimer’s disease (AD) is the most common type of dementia in the elderly. Several hypotheses emerged from AD pathophysiological mechanisms. However, no neuronal protective or regenerative drug is available nowadays. Researchers still work in drug development and are finding new molecular targets to treat AD. Therefore, this study aimed to summarize main advances in AD pharmacological therapy. Clinical trials registered in the National Library of Medicine database were selected and analyzed accordingly to molecular targets, therapeutic effects, and safety profile. The most common outcome was the lack of efficacy. Only seven trials concluded that tested drugs were safe and induced any kind of therapeutic improvement. Three works showed therapeutic effects followed by toxicity. In addition to aducanumab recent FDA approval, antibodies against amyloid-β (Aβ) showed no noteworthy results. 5-HT6 antagonists, tau inhibitors and nicotinic agonists’ data were discouraging. However, anti-Aβ vaccine, BACE inhibitor and anti-neuroinflammation drugs showed promising results.
Type of Medium:
Online Resource
ISSN:
1663-9812
DOI:
10.3389/fphar.2023.1101452
DOI:
10.3389/fphar.2023.1101452.s001
DOI:
10.3389/fphar.2023.1101452.s002
DOI:
10.3389/fphar.2023.1101452.s003
DOI:
10.3389/fphar.2023.1101452.s004
DOI:
10.3389/fphar.2023.1101452.s005
DOI:
10.3389/fphar.2023.1101452.s006
DOI:
10.3389/fphar.2023.1101452.s007
DOI:
10.3389/fphar.2023.1101452.s008
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2587355-6
SSG:
15,3
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