In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-15), p. e0276138-
Abstract:
Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) 〉 1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p 〈 0.001).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0276138
DOI:
10.1371/journal.pone.0276138.g001
DOI:
10.1371/journal.pone.0276138.g002
DOI:
10.1371/journal.pone.0276138.g003
DOI:
10.1371/journal.pone.0276138.t001
DOI:
10.1371/journal.pone.0276138.t002
DOI:
10.1371/journal.pone.0276138.t003
DOI:
10.1371/journal.pone.0276138.t004
DOI:
10.1371/journal.pone.0276138.s001
DOI:
10.1371/journal.pone.0276138.r001
DOI:
10.1371/journal.pone.0276138.r002
DOI:
10.1371/journal.pone.0276138.r003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Bookmarklink