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  • 1
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    Online Resource
    Predicting Severity and Intrahospital Mortality in COVID-19: The Place and Role of Oxidative Stress
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-3-26), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-3-26), p. 1-15
    Abstract: SARS-CoV-2 virus causes infection which led to a global pandemic in 2020 with the development of severe acute respiratory syndrome. Therefore, this study was aimed at examining its possible role in predicting severity and intrahospital mortality of COVID-19, alongside with other laboratory and biochemical procedures, clinical signs, symptoms, and comorbidity. This study, approved by the Ethical Committee of Clinical Center Kragujevac, was designed as an observational prospective cross-sectional clinical study which was conducted on 127 patients with diagnosed respiratory COVID-19 viral infection from April to August 2020. The primary goals were to determine the predictors of COVID-19 severity and to determine the predictors of the negative outcome of COVID-19 infection. All patients were divided into three categories: patients with a mild form, moderate form, and severe form of COVID-19 infection. All biochemical and laboratory procedures were done on the first day of the hospital admission. Respiratory ( p 〈 0.001 ) and heart ( p = 0.002 ) rates at admission were significantly higher in patients with a severe form of COVID-19. From all observed hematological and inflammatory markers, only white blood cell count ( 9.43 ± 4.62 , p = 0.001 ) and LDH ( 643.13 ± 313.3 , p = 0.002 ) were significantly higher in the severe COVID-19 group. We have observed that in the severe form of SARS-CoV-2, the levels of superoxide anion radicals were substantially higher than those in two other groups ( 11.3 ± 5.66 , p 〈 0.001 ) and the nitric oxide level was significantly lower in patients with the severe disease ( 2.66 ± 0.45 , p 〈 0.001 ). Using a linear regression model, TA, anosmia, ageusia, O2−, and the duration at the ICU are estimated as predictors of severity of SARS-CoV-2 disease. The presence of dyspnea and a higher heart rate were confirmed as predictors of a negative, fatal outcome. Results from our study show that presence of hypertension, anosmia, and ageusia, as well as the duration of ICU stay, and serum levels of O2− are predictors of COVID-19 severity, while the presence of dyspnea and an increased heart rate on admission were predictors of COVID-19 mortality.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6615787
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 2
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    Online Resource
    Hepatitis C Therapy – Related Haematological Side Effects are Associated with Treatment Outcome / Hematološka Neželjena Dejstva Terapije Hepatitisa C Su Povezana Sa Ishodom Lecenja
    Walter de Gruyter GmbH ; 2016
    In:  Serbian Journal of Experimental and Clinical Research Vol. 17, No. 1 ( 2016-3-1), p. 9-14
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 17, No. 1 ( 2016-3-1), p. 9-14
    Abstract: Treatment of patients suffering from chronic hepatitis C with standard pegylated interferon alpha 2a plus ribavirin has limited efficacy. Therapy outcome is dependent on several factors of both the host and virus, including age, sex, stage of fibrosis, viral genotype, viral load, and occurrence of haematological adverse events during chronic hepatitis C treatment. The aim of this study was to determine the relationship between the viral and host factors and the haematological side effects of therapy with sustained virological response. Fifty-four patients were treated with combined pegylated interferon alpha 2a plus ribavirin therapy. Hepatitis C virus genotyping, viral load, histopathological liver changes and biochemical parameters were evaluated for each patient before beginning treatment. Each patient’s blood count was analysed during each clinical visit. Sustained virological response was achieved in 75,9% of patients. Baseline AST and ALT levels were significantly higher in patients with a poor response to therapy (p 〈 0,05). Other clinical and laboratory parameters did not reach statistical significance. Both responders and non-responders developed anaemia. A decrease in thrombocytes, neutrophils and white blood cells was significantly associated with a sustained response to therapy (p 〈 0,05, p 〈 0,05 and p 〈 0,001, respectively). Sustained virological response was associated with lower baseline AST and ALT values and thrombocytopenia, leucopenia and neutropenia at the end of the treatment. All treated patients developed anaemia.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.1515/sjecr-2015-0036
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2710266-X
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  • 3
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    Online Resource
    HCV Infection and Chronic Renal Disease
    Walter de Gruyter GmbH ; 2021
    In:  Serbian Journal of Experimental and Clinical Research Vol. 0, No. 0 ( 2021-05-26)
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2021-05-26)
    Abstract: Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indirectly. Behind hepatic, HCV can cause extra-hepatic manifestations. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and outcome.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.2478/sjecr-2021-0010
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2710266-X
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  • 4
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    Online Resource
    Sepsis and cardiorenal syndrome: Etiopathogenesis, diagnosis and treatment
    Walter de Gruyter GmbH ; 2013
    In:  Serbian Journal of Experimental and Clinical Research Vol. 14, No. 4 ( 2013), p. 181-187
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 14, No. 4 ( 2013), p. 181-187
    Type of Medium: Online Resource
    ISSN: 1820-8665
    URL: Article
    DOI: 10.5937/sjecr14-4363
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2013
    detail.hit.zdb_id: 2710266-X
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  • 5
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    Online Resource
    Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients
    Hindawi Limited ; 2017
    In:  Disease Markers Vol. 2017 ( 2017), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: Hepatitis C virus infection (HCV), one of the greatest causes of liver disease, is a frequent complication in patients with end-stage renal disease (ESRD) on dialysis. ESRD is defined as decreased glomerular filtration and also accompanied by impaired function of the immune system. Galectin-3 is a β -galactoside-binding lectin, involved in various biological processes including pathogenesis of chronic renal disease. The aim of our study was to estimate disease severity in ESRD HCV + patients and analyze the serum concentrations of IL-1 β , IL-4, IL-23, and IL-6; anti-HCV antibodies; and galectin-3. Also, we attempted to determine potential correlation between galectin-3 level and parameters of disease severity ALT and AST. Our results showed decreased levels of ALT and AST ( p = 0.00 ), demonstrating less liver destruction in ESRD HCV + patients in comparison to HCV + patients. Increased levels of IL-6 ( p = 0.03 ) implicate a hepatoprotective role of IL-6 in these patients. Also, level of galectin-3 ( p = 0.00 ) in the serum of ESRD HCV + patients was higher than that of HCV + patients. This alteration was accompanied with negative correlation between galectin-3 and AST and ALT, respectively ( p = 0.029 ; p = 0.033 ). The presence of increased systemic levels of IL-6 and Gal-3 in ESRD HCV + patients may be an attempt to counteract or limit ongoing proinflammatory processes and to downregulate chronic inflammation, suggesting the new aspects of HCV infection in ESRD patients.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2017/6275987
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2033253-1
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  • 6
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    Boceprevir in genotype 1 chronic hepatitis C: First experiences in Serbia
    National Library of Serbia ; 2015
    In:  Srpski arhiv za celokupno lekarstvo Vol. 143, No. 1-2 ( 2015), p. 35-41
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 143, No. 1-2 ( 2015), p. 35-41
    Abstract: nema
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH1502035S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2015
    detail.hit.zdb_id: 2577665-4
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  • 7
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    Online Resource
    Risk factors of nosocomial infections caused by piperacillin-tazobactam resistant Pseudomonas aeruginosa
    National Library of Serbia ; 2013
    In:  Srpski arhiv za celokupno lekarstvo Vol. 141, No. 9-10 ( 2013), p. 640-647
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 141, No. 9-10 ( 2013), p. 640-647
    Abstract: Uvod. Pseudomonas aeruginosa je cest uzrocnik teskih infekcija hospitalizovanih osoba i povezan je s visokim stopama bolnickog morbiditeta i mortaliteta. Cilj rada. Cilj studije bio je da se utvrde faktori rizika za bolnicke infekcije izazvane bakterijom P. aeruginosa rezistentnom na piperacilin?tazobaktam (PT-RPA). Metode rada. Uradjeno je anamnesticko istrazivanje u Klinickom centru u Kragujevcu od januara 2010. do decembra 2011. godine. Rezultati. Tokom posmatranog perioda infekcija PT-RPA je zabelezena kod 79 obolelih osoba (38,16%), dok su kod 128 bolesnika (61,84%) dijagnostikovane infekcije izazvane bakterijom P. aeruginosa osetljivom na piperacilin?tazobaktam (PT-SPA). Pneumonije su cesce registrovane kod ispitanika s infekcijama PT-RPA (55,70%; p〈0,05), dok su infekcije urinarnog trakta bile cesce u grupi bolesnika s infekcijama PT-SPA (26,56%; p〈0,01). Multivarijantna analiza je kao faktore rizika nezavisno povezane s infekcijom PT-RPA izdvojila: traumu na prijemu (OR=3,089; 95%CI=1,438-6,635; p=0,004) i primenu imipenema (OR=15,027; 95%CI=1,778-127,021; p=0,013), meropenema (OR=2,618; 95%CI=1,030-6,653; p=0,043), ciprofloksacina (OR=3,380; 95%CI=1,412- 8,090; p=0,006), vankomicina (OR=4,294; 95%CI=1,477-12,479; p=0,007) i piperacilin?tazobaktama (OR=4,047; 95%CI=1,395-11,742; p=0,010). Zakljucak. Kod bolnicki lecenih pacijenata rizik za nastanak infekcije PT-RPA u vezi je s prethodnom upotrebom imipenema, meropenema, ciprofloksacina, vankomicina, piperacilin?tazobaktama i postojanjem traume na prijemu.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH1310640D
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2577665-4
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  • 8
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    Online Resource
    Micro-elimination of HCV as a possible therapeutic strategy: our experience and a review of literature
    Journal of Infection in Developing Countries ; 2020
    In:  The Journal of Infection in Developing Countries Vol. 14, No. 02 ( 2020-02-29), p. 117-124
    Details
    In: The Journal of Infection in Developing Countries, Journal of Infection in Developing Countries, Vol. 14, No. 02 ( 2020-02-29), p. 117-124
    Abstract: Background: Serbia has an intermediate estimated prevalence of chronic hepatitis C (CHC) infection, approximately 1.13%, with hepatitis C remaining one of the leading causes of liver-related morbidity and mortality in Serbia with impaired quality of life and overwhelming cost of treating its complications As the availability of new treatment options and resources for screening remains limited, micro-elimination of CHC becomes a top priority. Methods: Review of the available published data related to the clinical and epidemiological situation of the hepatitis C infection in Serbia, including the unpublished data from the databases of four major reference centres in Serbia (Clinical Center Serbia, Clinical Center Niš, Clinical Center Vojvodina and Clinical Center Kragujevac). Results: Currently in Serbia, micro-elimination appears to be realistic in the patients with haemophilia, who represent a small, well-defined subpopulation, under constant monitoring by the healthcare system. Other feasible targets for micro-elimination of CHC infection in Serbia are patients on hemodialysis, prisoners and people who inject drugs. Conclusions: Micro-elimination is feasible in Serbia, especially in the subpopulation of patients with haemophilia. This may represent an initial step towards achieving the WHO objective to eliminate hepatitis C infection by 2030.
    Type of Medium: Online Resource
    ISSN: 1972-2680
    URL: Article
    DOI: 10.3855/jidc.11785
    Language: Unknown
    Publisher: Journal of Infection in Developing Countries
    Publication Date: 2020
    detail.hit.zdb_id: 2394024-4
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  • 9
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    Online Resource
    Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection
    Journal of Infection in Developing Countries ; 2020
    In:  The Journal of Infection in Developing Countries Vol. 14, No. 05 ( 2020-05-31), p. 519-526
    Details
    In: The Journal of Infection in Developing Countries, Journal of Infection in Developing Countries, Vol. 14, No. 05 ( 2020-05-31), p. 519-526
    Abstract: Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and blood products, nosocomial transmission of HCV, and prolong hemodialysis duration. The aim of the study was to evaluate the influence of IL-33/ST2 signaling pathway on severity of the liver disease in ESRD HCV+ patients. Methodology: Blood samples from patients with end stage renal disease (ESRD) and hepatitis C infection (HCV), 20 patients with HCV infection, 20 patients with ESRD and 20 healthy control donor patients were taken for the examination of biochemical parameters, for the determination of the serum cytokine concentration, and for the molecular diagnostics of HCV. Results: Systemic sST2 positively correlated with serum level of urea and creatinine, respectively. Serum sST2 was significantly increased in ESRD HCV+ patients in comparison to HCV+ group. sST2/IL-1, sST2/IL-4 and sST2/IL-23 ratios were significantly increased in serum of ESRD HCV+ patients in comparison to HCV+ patients. Significantly higher systemic level of sST2 and sST2/IL-1 and sST2/IL-4 ratios were measured in ESRD patients compared to non-ESRD patients. Conclusion: These results suggested that elevated level sST2, as the consequence of renal failure, causes less destruction of liver in HCV infection.
    Type of Medium: Online Resource
    ISSN: 1972-2680
    URL: Article
    DOI: 10.3855/jidc.11741
    Language: Unknown
    Publisher: Journal of Infection in Developing Countries
    Publication Date: 2020
    detail.hit.zdb_id: 2394024-4
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  • 10
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    Online Resource
    Reiter's syndrome after salmonella infection
    National Library of Serbia ; 2004
    In:  Srpski arhiv za celokupno lekarstvo Vol. 132, No. 3-4 ( 2004), p. 104-107
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 132, No. 3-4 ( 2004), p. 104-107
    Abstract: U radu su prikazana dva bolesnika sa Rajterovim (Reiter) sindromom nakon salmonelozne infekcije koji su leceni na Infektivnom odeljenju Klinicko-bolnickog centra u Kragujevcu. Kod prvog bolesnika su ce desetak dana posle pocetka salmonelozne infekcije najpre pojavili otok i bol desnog skocnog zgloba uz izrazenu konjunktivalnu injekciju, da bi se u naredna dva meseca sukcesivno pojavljivali i otoci na levom kolenskom, levom lakatnom i prvom metatarzofalangnom zglobu desnog stopala. Kod drugog bolesnika se dve nedelje nakon pocetka salmoneloze pojavljuje otok levog rucnog zgloba, a nedelju dana kasnije i otok desnog rucnog i desnog skocnog zgloba. Kod oba bolesnika bio je izrazen inflamacijski sindrom (visoke vrednosti sedimentacije, fibrinogena i S-reaktivnog proteina) uz negativne reumatoidne faktore i pozitivan antigen HLA-B27. Tok bolesti je u oba slucaja bio povoljan. Na primenjenu terapiju nesteroidnim antiinflamacijskim lekovima znaci artritisa su ce povukli posle tri meseca. Nisu registrovani recidivi artritisa u naredne cetiri godine kod prvog, odnosno dve godine kod drugog bolesnika.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH0404104C
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2004
    detail.hit.zdb_id: 2577665-4
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