In:
Hepatology Research, Wiley, Vol. 53, No. 1 ( 2023-01), p. 26-34
Abstract:
The real‐world efficacy of sofosbuvir/velpatasvir treatment for patients with hepatitis C virus‐related decompensated cirrhosis is unclear. We aimed to identify factors that improve liver functional reserve after treatment. Methods This was a multicenter retrospective study of 12‐week sofosbuvir/velpatasvir treatment. A total of 48 patients with Child–Pugh (CP) class B or C were enrolled at 11 institutions. We evaluated changes in liver functional reserve at 24 weeks post‐treatment. Results At baseline, 40 and eight patients were CP class B and C, respectively. The overall rate of sustained virologic response 12 weeks post‐treatment was 95.8% (46/48). Serum albumin, alanine aminotransferase and α‐fetoprotein levels, and the FIB‐4 index were significantly improved post‐treatment ( P 〈 0.05). Among patients who achieved sustained virologic response 12 weeks post‐treatment, those with CP class A increased from 0 to 24 patients (56%) at 24 weeks post‐treatment. In multivariate analysis, body mass index (BMI) ≥25 was an independent factor that inhibited CP class improvement ( P 〈 0.05). In decision tree analysis, after treatment, the initial divergent variable for CP class improvement was hepatic encephalopathy, followed by serum sodium level and BMI. Conclusion Sofosbuvir/velpatasvir treatment improved the liver functional reserve in patients with hepatitis C virus‐related decompensated cirrhosis at 24 weeks post‐treatment. However, BMI ≥25 inhibited improvement in CP class. Additionally, decision tree analysis revealed that a combination of hepatic encephalopathy, serum sodium levels, and BMI were diversity profiles associated with no improvement in liver functional reserve after the treatment.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2006439-1
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