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CYP3A5 Polymorphism In Serbian Paediatric Epileptic Patients On Carbamazepine Treatment

Milovanovic, Dragana Dragas ; Radosavljevic, Ivan ; Radovanovic, Marija ; [et al.]

Walter de Gruyter GmbH ; 2015

In: Serbian Journal of Experimental and Clinical Research Vol. 16, No. 2 ( 2015-6-1), p. 93-99

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In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 16, No. 2 ( 2015-6-1), p. 93-99

Abstract: Carbamazepine exhibits significant inter-individual variability in its efficacy and safety, which leads to unpredictable therapy outcomes for the majority of patients. Although its complex biotransformation depends on CYP3A5 activity, evidence of association between carbamazepine treatment outcomes and CYP3A5 functional variations remains inconclusive. The aim of the present study was to investigate the distribution of two of the functionally important CYP3A5 variants *2 and *3 as well as their effects on carbamazepine dose requirements, plasma concentrations and clearance in a Serbian population. The study involved 40 paediatric epileptic patients on steady-state carbamazepine treatment. Genotyping was conducted using the PCR-RFLP method, and carbamazepine plasma concentrations were determined using the HPLC method. CYP3A5*2 and *3 polymorphisms were found at frequencies of 0.0% and 97.5%, respectively, which corresponds well to previously published data for Caucasians. No differences in CYP3A5*3 allele frequencies were detected among epileptic patients in comparison to healthy volunteers within similar ethnic populations (p 〉 0.08), indicating that CYP3A5 polymorphism does not represent a risk factor for epilepsy development. There was an observed tendency towards lower dosage requirements (mean±SD: 15.06±4.45 mg/kg vs. 18.74±5.55 mg/kg; p=0.26), higher plasma concentrations (mean±SD: 0.45±0.13 mg/kg vs. 0.38±0.03 mg/kg; p=0.47) and lower clearance (mean±SD: 0.14±0.05 mg/kg vs. 0.15±0.01 mg/kg; p=0.79) of carbamazepine in homozygous carriers of CYP3A5*3/*3 compared to heterozygous CYP3A5*1A/*3 Serbians. Because these genotype groups did not differ significantly in terms of their carbamazepine pharmacokinetics parameters, the proposed effects of CYP3A5*3 on carbamazepine metabolism could not be confirmed.

Type of Medium: Online Resource

ISSN: 2335-075X , 1820-8665

URL: Article

DOI: 10.1515/sjecr-2015-0012

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2015

detail.hit.zdb_id: 2710266-X

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CYP1A2 genotype affects carbamazepine pharmacokinetics in children with epilepsy

Djordjevic, Natasa ; Milovanovic, Dragana Dragas ; Radovanovic, Marija ; [et al.]

Springer Science and Business Media LLC ; 2016

In: European Journal of Clinical Pharmacology Vol. 72, No. 4 ( 2016-4), p. 439-445

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In: European Journal of Clinical Pharmacology, Springer Science and Business Media LLC, Vol. 72, No. 4 ( 2016-4), p. 439-445

Type of Medium: Online Resource

ISSN: 0031-6970 , 1432-1041

URL: Article

DOI: 10.1007/s00228-015-2006-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 1459058-X

SSG: 15,3

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Generalized Quasi-Orthogonal Functional Networks Applied in Parameter Sensitivity Analysis of Complex Dynamical Systems

Nikolic, Sasa S. ; Antic, Dragan S. ; Dankovic, Nikola B. ; [et al.]

Kaunas University of Technology (KTU) ; 2022

In: Elektronika ir Elektrotechnika Vol. 28, No. 4 ( 2022-08-24), p. 19-26

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In: Elektronika ir Elektrotechnika, Kaunas University of Technology (KTU), Vol. 28, No. 4 ( 2022-08-24), p. 19-26

Abstract: This paper presents one possible application of generalized quasi-orthogonal functional networks in the sensitivity analysis of complex dynamical systems. First, a new type of first order (k = 1) generalized quasi-orthogonal polynomials of Legendre type via classical quasi-orthogonal polynomials was introduced. The short principle to design generalized quasi-orthogonal polynomials and filters was also shown. A generalized quasi-orthogonal functional network represents an extension of classical orthogonal functional networks and neural networks, which deal with general functional models. A sequence of the first order (k = 1) generalized quasi-orthogonal polynomials was used as a new basis in the proposed generalized quasi-orthogonal functional networks. The proposed method for determining the parameter sensitivity of complex dynamical systems is also given, and an example of a complex industrial system in the form of a tower crane was considered. The results obtained have been compared with different methods for parameter sensitivity analysis.

Type of Medium: Online Resource

ISSN: 2029-5731 , 1392-1215

URL: Article

DOI: 10.5755/j02.eie.31110

Language: Unknown

Publisher: Kaunas University of Technology (KTU)

Publication Date: 2022

detail.hit.zdb_id: 2713230-4

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Pharmacokinetics of vancomycin in patients with different renal function levels

Zaric, Radica Zivkovic ; Milovanovic, Jasmina ; Rosic, Nikola ; [et al.]

Walter de Gruyter GmbH ; 2018

In: Open Medicine Vol. 13, No. 1 ( 2018-10-22), p. 512-519

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In: Open Medicine, Walter de Gruyter GmbH, Vol. 13, No. 1 ( 2018-10-22), p. 512-519

Abstract: There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.

Type of Medium: Online Resource

ISSN: 2391-5463

URL: Article

DOI: 10.1515/med-2018-0068

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2018

detail.hit.zdb_id: 2829380-0

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Antitumour Effect of a Mixture of N-Propyl Polysulfides In Vitro

Djordjevic, Dragana ; Milovanovic, Jelena ; Jurisevic, Milena ; [et al.]

Centre for Evaluation in Education and Science (CEON/CEES) ; 2019

In: Serbian Journal of Experimental and Clinical Research Vol. 20, No. 4 ( 2019-12-01), p. 295-300

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In: Serbian Journal of Experimental and Clinical Research, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 20, No. 4 ( 2019-12-01), p. 295-300

Abstract: Copper serves as a limiting factor for multiple steps of tumour progression, including angiogenesis, growth and metastasis. High levels of copper have been found in a wide spectrum of human cancers. Antitumour activities of copper-chelating drugs have been reported in animal models. Organosulfur compounds (diallyl sulfide, DAS; diallyl disulfide, DADS; S-ethylcysteine, SEC; N-acetylcysteine, NAC) derived from garlic exhibit marked copper-chelating activity. We analysed a mixture of fifteen n-propyl polysulfides (DPPS) for potential antitumour activity against several murine tumour cell lines, including colon carcinoma (CT26), mammary carcinoma (4T1) and melanoma cell lines (B16F10), and compared the effects with the antiproliferative effect in highly proliferative murine mesenchymal stem cells (mMSCs). The effects of the mixture of n-propyl polysulfides (100%) on cell viability were determined using MTT assays. Cell apoptosis was analysed using Annexin V-FITC/PI assays. The results of the MTT assays indicate that this standardized mixture of n-propyl polysulfides has a strong, dose-dependent cytotoxic effect against all three of the tested tumour cell lines (CT26, 4T1, B16F10). The cytotoxic effect of the n-propyl polysulfide mixture against the CT26 and B16F10 cell lines was much stronger than that of cisplatin and was significantly weaker in mMSCs, which are non-cancerous and highly proliferative cells, than in cancer cells. Flow cytometric analysis of CT26 and 4T1 cells revealed that apoptosis was not the dominant mechanism of cell death induced by the n-propyl polysulfide mixture. The n-propyl polysulfide mixture exerted highly cytotoxic activity against murine colon carcinoma and melanoma cell lines, but its antiproliferative activity against mMSCs was significantly lower than that of cisplatin.

Type of Medium: Online Resource

ISSN: 2335-075X , 1820-8665

URL: Article

DOI: 10.1515/sjecr-2017-0069

Language: English

Publisher: Centre for Evaluation in Education and Science (CEON/CEES)

Publication Date: 2019

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Population Pharmacokinetics of Vancomycin in Adult Patients with Long Bones’ Fractures

Milovanovic, Jasmina ; Zaric, Radica Zivkovic ; Rosic, Nikola ; [et al.]

Walter de Gruyter GmbH ; 2021

In: Serbian Journal of Experimental and Clinical Research Vol. 22, No. 3 ( 2021-09-01), p. 233-240

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In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 22, No. 3 ( 2021-09-01), p. 233-240

Abstract: Vancomycin is a tricyclic glycopeptide antibiotic, mostly used in the treatment of severe staphylococcal and enterococcal infections, especially in orthopedic surgery. The purpose of this analysis was to develop a population pharmacokinetic (PPK) model of vancomycine in hospitalized patients with bone fractures and identify important factors which influence its clearance (CL). A total of ninety-nine measurements of vancomycin serum concentrations were used in our population modeling. A two-compartment model was applied to describe the pharmacokinetics of vancomycin using subroutines ADVAN3 and TRANS4. The study population included patients of both sexes, with the mean age of 62.12±14.69 years and body weight of 80.32±12.44kg. Vancomycin was administered as intravenous infusion with average daily dose of 1772.73±521.34mg. Out of twenty different factors evaluated in the study (including demographic, clinical and laboratory data), only daily dose of vancomycin (DD) and co-medication with piperacillin/tazobactam (PT) showed significant effect on clearance of vancomycin. The final model was described by the following equation: CL (l/h) = 0.03 + 0.000468 x DD + 0.675 x PT. Bootstrapping was used for validation of the final model. In conclusion, the main causes of variability in the clearance of vancomycin among adult patients with bone fractures are daily dose of vancomycin and co-medication with piperacillin/tazobactam.

Type of Medium: Online Resource

ISSN: 2335-075X , 1820-8665

URL: Article

DOI: 10.2478/sjecr-2019-0025

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2021

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Clinical Pharmacokinetics of Second-Generation Triazoles for the Treatment of Invasive Aspergillosis and Candidiasis

Jović, Zorica ; Janković, Slobodan M. ; Ružić Zečević, Dejana ; [et al.]

Springer Science and Business Media LLC ; 2019

In: European Journal of Drug Metabolism and Pharmacokinetics Vol. 44, No. 2 ( 2019-04-09), p. 139-157

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In: European Journal of Drug Metabolism and Pharmacokinetics, Springer Science and Business Media LLC, Vol. 44, No. 2 ( 2019-04-09), p. 139-157

Type of Medium: Online Resource

ISSN: 0378-7966 , 2107-0180

URL: Article

DOI: 10.1007/s13318-018-0513-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2558337-2

SSG: 15,3

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Influence of mental disorders on working ability assessment

Novakovic, Milan ; Milovanovic, Aleksandar ; Jakovljevic, Branko ; [et al.]

National Library of Serbia ; 2007

In: Military Medical and Pharmaceutical Journal of Serbia Vol. 64, No. 11 ( 2007), p. 733-737

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In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 64, No. 11 ( 2007), p. 733-737

Abstract: Uvod/Cilj. U Bosni i Hercegovini (BiH) postoji sve veci broj zahteva za ocenu radne sposobnosti (ORS) zbog nizeg nivoa socijalne zastite radnika i porasta broja bolesnika sa psihickim oboljenjima. Cilj ovog rada bio je da se utvrdi uticaj psihickih bolesti na nastanak invalidnosti I i III kategorije na drugostepenom organu vestacenja u BiH u periodu od 01.01.2005. do 31.12.2006. godine. Metode. Studija je obuhvatila 1 792 ispitanika od kojih je 921 bilo sa potpunim gubitkom radne sposobnosti (I kategorija invalidnosti), dok su invalidnost III grupe cinile osobe koje su imale preostalu radnu sposobnost (RS) (n = 871). Za ovu multicentarsku retrospektivnu studiju instrumenti istrazivanja bili su obrasci P-6 i D-2 za staz u BiH, IN obrazac za lica sa inostranim stazom i upitnik osobina licnosti (EPQ). Rezultati. Studija je obuhvatila 1 494 muskarca (78,5%) i 298 zena (21,5%). Univarijantnom analizom dobijena je visoka znacajnost (p = 0,001) za: uzrast (?2 = 65,428), radni staz (?2 = 28,438), alkoholizam (?2 = 33,234), nikotinizam (?2 = 70,880), edukaciju oca (?2 = 58,124), migracije (?2 = 14,874), bolovanja (?2 = 29,190), lecenja (?2 = 95,073), rehabilitacije (?2 = 29,453). Multivarijantna analiza ukazala je na uticaj sledecih parametara na invalidnost I grupe: staz, bolovanja, psihoticizam i depresija (p = 0,001), a bolnicka lecenja i fatigacija uticali su na invalidnost obe grupe. Psihicka oboljenja bila su uzrok invalidnosti I kategorije kod 14,98%, a invalidnosti III kategorije kod 9,3% osoba. Vodece bolesti kod invalidnosti I i III kategorije bile su depresija i shizofrenija, a potom: alkoholizam, anksioznost, mozdani organski psihosindrom (MOPS) i ostale bolesti. Zakljucak. Najveci uticaj na invalidnost I kategorije imaju: staz, bolovanja, psihoticizam i depresija, a na invalidnost III kategorije: dugotrajna bolest, vise lecenja i fatigacija.

Type of Medium: Online Resource

ISSN: 0042-8450 , 2406-0720

URL: Article

DOI: 10.2298/VSP0711733N

Language: English

Publisher: National Library of Serbia

Publication Date: 2007

detail.hit.zdb_id: 2169819-3

SSG: 15,3

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Late-onset systemic lupus erythematosus: clinical features, course, and prognosis

Tomic-Lucic, Aleksandra ; Petrovic, Radmila ; Radak-Perovic, Marija ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Clinical Rheumatology Vol. 32, No. 7 ( 2013-7), p. 1053-1058

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In: Clinical Rheumatology, Springer Science and Business Media LLC, Vol. 32, No. 7 ( 2013-7), p. 1053-1058

Type of Medium: Online Resource

ISSN: 0770-3198 , 1434-9949

URL: Article

DOI: 10.1007/s10067-013-2238-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1480901-1

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Attitudes and Opinions of Biomedical Students: Digital Education Questionnaire

Nikolic Turnic, Tamara ; Mijailovic, Sara ; Nikolic, Maja ; [et al.]

MDPI AG ; 2022

In: Sustainability Vol. 14, No. 15 ( 2022-08-08), p. 9751-

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In: Sustainability, MDPI AG, Vol. 14, No. 15 ( 2022-08-08), p. 9751-

Abstract: (1) Background: the purpose of this study was a preliminary analysis of current methods of online teaching at the Faculty of Medical Sciences, University of Kragujevac, Republic of Serbia, in order to define the attitudes of biomedical students about education during the COVID-19 pandemic and to validate of the education medical questionnaire (eMedQ), a new tool for the assessment of the students’ perceptions about digital education. (2) Methods: this was a qualitative cross-sectional observational study that used the originally developed 45-item questionnaire (eMedQ) as an assessment instrument conducted on biomedical students (n = 209) of all study years at the Faculty of Medical Sciences, University of Kragujevac (Republic of Serbia), during winter semester or between September 2021 and January 2022. (3) Results: In this study, a Cronbach’s alpha value of 0.904 was obtained, which indicated good internal consistency; the correlation matrix revealed many coefficients greater than 0.3, denoting high correlations between the items. The Kaiser–Meyer–Olkin measure of sampling adequacy was 0.866 and Bartlett’s test of sphericity was significant (p 〈 0.001). The PCA revealed the presence of seven components with characteristic values over one, while three factors explained the highest percentage of variance. (4) Conclusions: this research developed and validated a new tool for evaluation of biomedical student perceptions about digital education.

Type of Medium: Online Resource

ISSN: 2071-1050

URL: Article

DOI: 10.3390/su14159751

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2518383-7

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