In:
PLOS Biology, Public Library of Science (PLoS), Vol. 19, No. 7 ( 2021-7-1), p. e3001055-
Abstract:
It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D 1 -like receptor (D 1 R) and D 2 -like receptor (D 2 R) to cost–benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D 1 R/D 2 R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D 1 R or D 2 R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D 2 R antagonism. In addition, blocking both D 1 R and D 2 R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001055
DOI:
10.1371/journal.pbio.3001055.g001
DOI:
10.1371/journal.pbio.3001055.g002
DOI:
10.1371/journal.pbio.3001055.g003
DOI:
10.1371/journal.pbio.3001055.g004
DOI:
10.1371/journal.pbio.3001055.g005
DOI:
10.1371/journal.pbio.3001055.g006
DOI:
10.1371/journal.pbio.3001055.g007
DOI:
10.1371/journal.pbio.3001055.s001
DOI:
10.1371/journal.pbio.3001055.s002
DOI:
10.1371/journal.pbio.3001055.s003
DOI:
10.1371/journal.pbio.3001055.s004
DOI:
10.1371/journal.pbio.3001055.s005
DOI:
10.1371/journal.pbio.3001055.s006
DOI:
10.1371/journal.pbio.3001055.s007
DOI:
10.1371/journal.pbio.3001055.s008
DOI:
10.1371/journal.pbio.3001055.s009
DOI:
10.1371/journal.pbio.3001055.s010
DOI:
10.1371/journal.pbio.3001055.s011
DOI:
10.1371/journal.pbio.3001055.s012
DOI:
10.1371/journal.pbio.3001055.r001
DOI:
10.1371/journal.pbio.3001055.r002
DOI:
10.1371/journal.pbio.3001055.r003
DOI:
10.1371/journal.pbio.3001055.r004
DOI:
10.1371/journal.pbio.3001055.r005
DOI:
10.1371/journal.pbio.3001055.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2126773-X
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