In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 157, No. 2 ( 2007-08), p. 195-200
Abstract:
Objective : Many polycystic ovary syndrome (PCOS) women suffer from adiposity and insulin resistance (IR), which play an important role in the development and maintenance of PCOS. Adipocyte fatty acid-binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity and IR. Thus, as observed with other adipose tissue derived factors, secreted A-FABP might be involved in the pathogenesis of obesity-associated disorders such as PCOS. Design : Plasma A-FABP concentrations were measured in 102 non-diabetic PCOS women, and associations with markers of obesity, IR, inflammation, and hyperandrogenism were investigated by correlation and multiple linear regression analyses. The effect of lifestyle intervention on A-FABP was studied in a second cohort of 17 obese PCOS women. Results : A-FABP correlated with body mass index (BMI; R = 0.694, P 〈 0.001), dual-energy X-ray-absorptiometry (DEXA) fat mass ( R = 0.729, P 〈 0.001), DEXA lean body mass ( R = 0.399, P = 0.001), HOMA %S ( R = −0.435, P 〈 0.001), hsCRP ( R = 0.355, P = 0.001), and free testosterone (fT; R = 0.230, P = 0.02). Adjusted for age, smoking, and glucose metabolism the association of A-FABP with HOMA %S was still significant ( P 〈 0.001), whereas the associations with fT ( P = 0.09) and hsCRP ( P = 0.25) were not. Inclusion of BMI into the model abolished the impact of A-FABP on HOMA %S. In BMI-matched PCOS women ( n = 20 pairs), neither HOMA %S ( P = 0.3) nor fT ( P = 0.6) were different despite different A-FABP levels ( P 〈 0.001), and in 17 obese PCOS women undergoing a lifestyle intervention, changes in IR were not paralleled by changes in A-FABP. Conclusions : Circulating A-FABP was correlated with markers of obesity, but had no major impact on IR, inflammation, or hyperandrogenemia in PCOS women.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2007
detail.hit.zdb_id:
1485160-X
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