In:
Applied Organometallic Chemistry, Wiley, Vol. 36, No. 1 ( 2022-01)
Abstract:
Herein, A type of Pt(0) complexes based on fullerene C 60 including phosphorus ylides as monodentate ligands, [(η 2 ‐C 60 )Pt( Y 1–4 ) 2 ] ( Y 1 = PPh 3 CHC(O)C 6 H 4 ‐ p ‐NO 2 , Y 2 = PPh 3 CHC(O)C 6 H 4 ‐ p ‐CH 3 , Y 3 = ( p ‐tolyl) 3 P‐CHC(O)C 6 H 4 ‐ p ‐NO 2 , Y 4 = ( p ‐tolyl) 3 P‐CHC(O)C 6 H 4 ‐ p ‐CH 3 ), were synthesized via adding of related monodentate phosphorus ylide to toluene solution of C 60 and Pt (dba) 2 (dba = dibenzylideneacetone). The structures were identified using IR, NMR ( 1 H, 13 C, and 31 P), UV–visible, ESI‐MS, and EDX spectroscopies, thermal curve TGA, and electron microscopic images (scanning electron microscopy, SEM, and transmission electron microscopy, TEM). The molecular structure of complexes clearly shows that two ylidic ligands in a cis configuration and two hexagons of C 60 in the junction[6,6] coordinate to Pt(0) metal center. These complexes were treated as biological agents in antibacterial, antioxidant, and anticancer assessments. Three Gram‐negative ( Escherichia coli , Salmonella typhimurium , and Shigella dysenteriae ) and three Gram‐positive bacteria ( Bacillus subtilis , Bacillus cereus , and Staphylococcus aureus ) were used for antibacterial investigation. The activities of complexes against cancer cells were also tested using AGS (gastric carcinoma), A549 (non‐small lung carcinoma), and MCF‐7 (breast carcinoma) cell lines. All biological studies on synthesized nanocomplexes showed promising effects in comparison with standards.
Type of Medium:
Online Resource
ISSN:
0268-2605
,
1099-0739
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1480791-9
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