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Renal systems biology of patients with systemic inflammatory response syndrome

Tsalik, Ephraim L. ; Willig, Laurel K. ; Rice, Brandon J. ; [et al.]

Elsevier BV ; 2015

In: Kidney International Vol. 88, No. 4 ( 2015-10), p. 804-814

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In: Kidney International, Elsevier BV, Vol. 88, No. 4 ( 2015-10), p. 804-814

Type of Medium: Online Resource

ISSN: 0085-2538

URL: Article

DOI: 10.1038/ki.2015.150

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 2007940-0

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Streamlined System for Purifying and Quantifying a Diverse Library of Compounds and the Effect of Compound Concentration Measurements on the Accurate Interpretation of Biological Assay Results

Popa-Burke, Ioana G. ; Issakova, Olga ; Arroway, James D. ; [et al.]

American Chemical Society (ACS) ; 2004

In: Analytical Chemistry Vol. 76, No. 24 ( 2004-12-01), p. 7278-7287

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In: Analytical Chemistry, American Chemical Society (ACS), Vol. 76, No. 24 ( 2004-12-01), p. 7278-7287

Type of Medium: Online Resource

ISSN: 0003-2700 , 1520-6882

URL: Article

DOI: 10.1021/ac0491859

DOI: 10.1021/ac0491859.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2004

detail.hit.zdb_id: 1483443-1

detail.hit.zdb_id: 1508-8

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Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling

Martin, Negin P. ; Mohney, Robert P. ; Dunn, Sara ; [et al.]

American Society for Pharmacology & Experimental Therapeutics (ASPET) ; 2006

In: Molecular Pharmacology Vol. 70, No. 5 ( 2006-11), p. 1643-1653

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In: Molecular Pharmacology, American Society for Pharmacology & Experimental Therapeutics (ASPET), Vol. 70, No. 5 ( 2006-11), p. 1643-1653

Type of Medium: Online Resource

ISSN: 0026-895X , 1521-0111

URL: Article

DOI: 10.1124/mol.106.028274

Language: English

Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)

Publication Date: 2006

detail.hit.zdb_id: 1475030-2

SSG: 15,3

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Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis

Mindikoglu, Ayse L. ; Opekun, Antone R. ; Putluri, Nagireddy ; [et al.]

Elsevier BV ; 2018

In: Translational Research Vol. 195 ( 2018-05), p. 25-47

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In: Translational Research, Elsevier BV, Vol. 195 ( 2018-05), p. 25-47

Type of Medium: Online Resource

ISSN: 1931-5244

URL: Article

DOI: 10.1016/j.trsl.2017.12.002

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2252085-5

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Large Scale Metabolic Profiling identifies Novel Steroids linked to Rheumatoid Arthritis

Yousri, Noha A. ; Bayoumy, Karim ; Elhaq, Wessam Gad ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Scientific Reports Vol. 7, No. 1 ( 2017-08-22)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-08-22)

Abstract: Recent metabolomics studies of Rheumatoid Arthritis (RA) reported few metabolites that were associated with the disease, either due to small cohort sizes or limited coverage of metabolic pathways. Our objective is to identify metabolites associated with RA and its cofounders using a new untargeted metabolomics platform. Moreover, to investigate the pathomechanism of RA by identifying correlations between RA-associated metabolites. 132 RA patients and 104 controls were analyzed for 927 metabolites. Metabolites were tested for association with RA using linear regression. OPLS-DA was used to discriminate RA patients from controls. Gaussian Graphical Models (GGMs) were used to identify correlated metabolites. 32 metabolites are identified as significantly (Bonferroni) associated with RA, including the previously reported metabolites as DHEAS, cortisol and androstenedione and extending that to a larger set of metabolites in the steroid pathway. RA classification using metabolic profiles shows a sensitivity of 91% and specificity of 88%. Steroid levels show variation among the RA patients according to the corticosteroid treatment; lowest in those taking the treatment at the time of the study, higher in those who never took the treatment, and highest in those who took it in the past. Finally, the GGM reflects metabolite relations from the steroidogenesis pathway.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-017-05439-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2615211-3

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Robust Metabolomic Signature is Associated with Altered Renal Hemodynamics in Patients with Cirrhosis

Mindikoglu, Ayse L. ; Opekun, Antone R. ; Coarfa, Cristian ; [et al.]

Elsevier BV ; 2017

In: Gastroenterology Vol. 152, No. 5 ( 2017-04), p. S1044-

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In: Gastroenterology, Elsevier BV, Vol. 152, No. 5 ( 2017-04), p. S1044-

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1016/S0016-5085(17)33534-5

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2017

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Amino acid metabolites that regulate G protein signaling during osmotic stress

Shellhammer, James P. ; Morin-Kensicki, Elizabeth ; Matson, Jacob P. ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS Genetics Vol. 13, No. 5 ( 2017-5-30), p. e1006829-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 13, No. 5 ( 2017-5-30), p. e1006829-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1006829

DOI: 10.1371/journal.pgen.1006829.g001

DOI: 10.1371/journal.pgen.1006829.g002

DOI: 10.1371/journal.pgen.1006829.g003

DOI: 10.1371/journal.pgen.1006829.g004

DOI: 10.1371/journal.pgen.1006829.g005

DOI: 10.1371/journal.pgen.1006829.g006

DOI: 10.1371/journal.pgen.1006829.g007

DOI: 10.1371/journal.pgen.1006829.s001

DOI: 10.1371/journal.pgen.1006829.s002

DOI: 10.1371/journal.pgen.1006829.s003

DOI: 10.1371/journal.pgen.1006829.s004

DOI: 10.1371/journal.pgen.1006829.s005

DOI: 10.1371/journal.pgen.1006829.s006

DOI: 10.1371/journal.pgen.1006829.s007

DOI: 10.1371/journal.pgen.1006829.s008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2186725-2

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Biomarkers of Inflammation, Immunosuppression and Stress Are Revealed by Metabolomic Profiling of Tuberculosis Patients

Weiner, January ; Parida, Shreemanta K. ; Maertzdorf, Jeroen ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 7 ( 2012-7-23), p. e40221-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 7 ( 2012-7-23), p. e40221-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0040221

DOI: 10.1371/journal.pone.0040221.g001

DOI: 10.1371/journal.pone.0040221.g002

DOI: 10.1371/journal.pone.0040221.g003

DOI: 10.1371/journal.pone.0040221.g004

DOI: 10.1371/journal.pone.0040221.g005

DOI: 10.1371/journal.pone.0040221.t001

DOI: 10.1371/journal.pone.0040221.t002

DOI: 10.1371/journal.pone.0040221.s001

DOI: 10.1371/journal.pone.0040221.s002

DOI: 10.1371/journal.pone.0040221.s003

DOI: 10.1371/journal.pone.0040221.s004

DOI: 10.1371/journal.pone.0040221.s005

DOI: 10.1371/journal.pone.0040221.s006

DOI: 10.1371/journal.pone.0040221.s007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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Correction: Biomarkers of Inflammation, Immunosuppression and Stress with Active Disease Are Revealed by Metabolomic Profiling of Tuberculosis Patients

Weiner, January ; Parida, Shreemanta K. ; Maertzdorf, Jeroen ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 12 ( 2012-12-26)

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 12 ( 2012-12-26)

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/annotation/b7f554bc-ad78-4745-9cd6-e14954d6a01d

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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Metabolite changes in blood predict the onset of tuberculosis

Weiner, January ; Maertzdorf, Jeroen ; Sutherland, Jayne S. ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Nature Communications Vol. 9, No. 1 ( 2018-12-06)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2018-12-06)

Abstract: New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3–24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. These prognostic metabolic signatures are consistent with development of subclinical disease prior to manifestation of active TB. Metabolic changes associated with pre-symptomatic disease are observed as early as 12 months prior to TB diagnosis, thus enabling timely interventions to prevent disease progression and transmission.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-018-07635-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2553671-0

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