In:
EMBO Molecular Medicine, EMBO, Vol. 6, No. 11 ( 2014-11), p. 1476-1492
Abstract:
image Inflammatory macrophages are shown here to play a central role in the mdx‐mouse pathology, a model for Duchenne muscular dystrophy. Genetic ablation or pharmacologic inhibition of CCR 2 confers therapeutic benefits in animals, improving muscle structure and function. CD 11b(high) macrophages ( MP ) derived from Ly6C(high) inflammatory monocytes are key pathogenesis mediators in the mdx mouse model of Duchenne muscular dystrophy. Loss of CCR 2 preferentially reduces CD 11b(high) MP accumulation in the mdx diaphragm and mitigates proinflammatory polarization of intramuscular MP . Genetic as well as pharmacological blockade of CCR 2 in mdx mice ameliorates dystrophic histopathologic features and improves mdx diaphragm muscle force production. CCR 2 blockade may serve as a useful therapeutic modulator of the immune response in muscular dystrophy.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201403967
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
2485479-7
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