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Table4.docx

Chauhan, Nar S. ; Pandey, Rajesh ; Mondal, Anupam K. ; [et al.]

Frontiers Media SA ; 2018

In: Frontiers in Microbiology Vol. 9 ( 2018-2-13)

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In: Frontiers in Microbiology, Frontiers Media SA, Vol. 9 ( 2018-2-13)

Type of Medium: Online Resource

ISSN: 1664-302X

URL: Article

DOI: 10.3389/fmicb.2018.00118

DOI: 10.3389/fmicb.2018.00118.s001

DOI: 10.3389/fmicb.2018.00118.s002

DOI: 10.3389/fmicb.2018.00118.s003

DOI: 10.3389/fmicb.2018.00118.s004

DOI: 10.3389/fmicb.2018.00118.s005

DOI: 10.3389/fmicb.2018.00118.s006

DOI: 10.3389/fmicb.2018.00118.s007

DOI: 10.3389/fmicb.2018.00118.s008

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2018

detail.hit.zdb_id: 2587354-4

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Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Hargrove-Grimes, Passley ; Mondal, Anupam K. ; Gumerson, Jessica ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Genetics Vol. 16, No. 12 ( 2020-12-23), p. e1009259-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2020-12-23), p. e1009259-

Abstract: Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcriptome data, we identified Rabgef1 (encoding the protein RabGEF1 or Rabex-5) as the only gene associated with Rab GTPases that exhibited strong concordance with retinal photoreceptor differentiation. Loss of Rabgef1 in mice ( Rabgef1 -/- ) resulted in defects specifically of photoreceptor morphology and almost complete loss of both rod and cone function as early as eye opening; however, aberrant outer segment formation could only partly account for visual function deficits. RabGEF1 protein in retinal photoreceptors interacts with Rabaptin-5, and RabGEF1 absence leads to reduction of early endosomes consistent with studies in other mammalian cells and tissues. Electron microscopy analyses reveal abnormal accumulation of macromolecular aggregates in autophagosome-like vacuoles and enhanced immunostaining for LC3A/B and p62 in Rabgef1 -/- photoreceptors, consistent with compromised autophagy. Transcriptome analysis of the developing Rabgef1 -/- retina reveals altered expression of 2469 genes related to multiple pathways including phototransduction, mitochondria, oxidative stress and endocytosis, suggesting an early trajectory of photoreceptor cell death. Our results implicate an essential role of the RabGEF1-modulated endocytic and autophagic pathways in photoreceptor differentiation and homeostasis. We propose that RabGEF1 and associated components are potential candidates for syndromic traits that include a retinopathy phenotype.

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1009259

DOI: 10.1371/journal.pgen.1009259.g001

DOI: 10.1371/journal.pgen.1009259.g002

DOI: 10.1371/journal.pgen.1009259.g003

DOI: 10.1371/journal.pgen.1009259.g004

DOI: 10.1371/journal.pgen.1009259.g005

DOI: 10.1371/journal.pgen.1009259.g006

DOI: 10.1371/journal.pgen.1009259.g007

DOI: 10.1371/journal.pgen.1009259.s001

DOI: 10.1371/journal.pgen.1009259.s002

DOI: 10.1371/journal.pgen.1009259.s003

DOI: 10.1371/journal.pgen.1009259.s004

DOI: 10.1371/journal.pgen.1009259.s005

DOI: 10.1371/journal.pgen.1009259.s006

DOI: 10.1371/journal.pgen.1009259.s007

DOI: 10.1371/journal.pgen.1009259.s008

DOI: 10.1371/journal.pgen.1009259.s009

DOI: 10.1371/journal.pgen.1009259.s010

DOI: 10.1371/journal.pgen.1009259.s011

DOI: 10.1371/journal.pgen.1009259.s012

DOI: 10.1371/journal.pgen.1009259.s013

DOI: 10.1371/journal.pgen.1009259.r001

DOI: 10.1371/journal.pgen.1009259.r002

DOI: 10.1371/journal.pgen.1009259.r003

DOI: 10.1371/journal.pgen.1009259.r004

DOI: 10.1371/journal.pgen.1009259.r005

DOI: 10.1371/journal.pgen.1009259.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2186725-2

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Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism

Corso-Díaz, Ximena ; Gentry, James ; Rebernick, Ryan ; [et al.]

Elsevier BV ; 2020

In: Cell Reports Vol. 31, No. 3 ( 2020-04), p. 107525-

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In: Cell Reports, Elsevier BV, Vol. 31, No. 3 ( 2020-04), p. 107525-

Type of Medium: Online Resource

ISSN: 2211-1247

URL: Article

DOI: 10.1016/j.celrep.2020.107525

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2649101-1

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Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

Brooks, Matthew J. ; Chen, Holly Y. ; Kelley, Ryan A. ; [et al.]

Elsevier BV ; 2019

In: Stem Cell Reports Vol. 13, No. 5 ( 2019-11), p. 891-905

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In: Stem Cell Reports, Elsevier BV, Vol. 13, No. 5 ( 2019-11), p. 891-905

Type of Medium: Online Resource

ISSN: 2213-6711

URL: Article

DOI: 10.1016/j.stemcr.2019.09.009

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2720528-9

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Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions

Campello, Laura ; Singh, Nivedita ; Advani, Jayshree ; [et al.]

Annual Reviews ; 2021

In: Annual Review of Vision Science Vol. 7, No. 1 ( 2021-09-15), p. 633-664

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In: Annual Review of Vision Science, Annual Reviews, Vol. 7, No. 1 ( 2021-09-15), p. 633-664

Abstract: Multifaceted and divergent manifestations across tissues and cell types have curtailed advances in deciphering the cellular events that accompany advanced age and contribute to morbidities and mortalities. Increase in human lifespan during the past century has heightened awareness of the need to prevent age-associated frailty of neuronal and sensory systems to allow a healthy and productive life. In this review, we discuss molecular and physiological attributes of aging of the retina, with a goal of understanding age-related impairment of visual function. We highlight the epigenome–metabolism nexus and proteostasis as key contributors to retinal aging and discuss lifestyle changes as potential modulators of retinal function. Finally, we deliberate promising intervention strategies for promoting healthy aging of the retina for improved vision.

Type of Medium: Online Resource

ISSN: 2374-4642 , 2374-4650

URL: Issue

URL: Article

DOI: 10.1146/vision.2021.7.issue-1

DOI: 10.1146/annurev-vision-100419-114940

Language: English

Publisher: Annual Reviews

Publication Date: 2021

detail.hit.zdb_id: 2805730-2

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Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Chen, Holly Y ; Swaroop, Manju ; Papal, Samantha ; [et al.]

eLife Sciences Publications, Ltd ; 2023

In: eLife Vol. 12 ( 2023-03-28)

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In: eLife, eLife Sciences Publications, Ltd, Vol. 12 ( 2023-03-28)

Abstract: Leber congenital amaurosis (LCA) is an inherited disease that affects the eyes and causes sight loss in early childhood, which generally gets worse over time. Individuals with this condition have genetic mutations that result in the death of light-sensitive cells, known as photoreceptors, in a region called the retina at the back of the eye. Patients carrying a genetic change in the gene CEP290 account for 20-25% of all LCA. At present, treatment options are only available for a limited number of patients with LCA. One option is to use small molecules as drugs that may target or bypass the faulty processes within the eye to help the photoreceptors survive in many different forms of LCA and other retinal diseases. However, over 90% of new drug candidates fail the first phase of clinical trials for human diseases. This in part due to the candidates having been developed using cell cultures or animal models that do not faithfully reflect how the human body works. Recent advances in cell and developmental biology are now enabling researchers to use stem cells derived from humans to grow retina tissues in a dish in the laboratory. These tissues, known as retinal organoids, behave in a more similar way to retinas in human eyes than those of traditional animal models. However, the methods for making and maintaining human retinal organoids are time-consuming and labor-intensive, which has so far limited their use in the search for new therapies. To address this challenge, Chen et al. developed a large-scale approach to grow retinal organoids from rd16 mutant mice stem cells (which are a good model for LCA caused by mutations to CEP290) and used the photoreceptors from these organoids to screen over 6,000 existing drugs for their ability to promote the survival of photoreceptors. The experiments found that the drug reserpine, which was previously approved to treat high blood pressure, also helped photoreceptors to survive in the diseased organoids. Reserpine also had a similar effect in retinal organoids derived from human patients with LCA and in the rd16 mice themselves. Further experiments suggest that reserpine may help patients with LCA by partially restoring a process by which the body destroys and recycles old and damaged proteins in the cells. The next steps following on from this work will be to perform further tests to demonstrate that this use of reserpine is safe to enter clinical trials as a treatment for LCA and other similar eye diseases.

Type of Medium: Online Resource

ISSN: 2050-084X

URL: Article

DOI: 10.7554/eLife.83205

Language: English

Publisher: eLife Sciences Publications, Ltd

Publication Date: 2023

detail.hit.zdb_id: 2687154-3

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Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

Mondal, Anupam K. ; Brock, Daniel C. ; Rowan, Sheldon ; [et al.]

Elsevier BV ; 2024

In: iScience Vol. 27, No. 2 ( 2024-02), p. 108979-

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In: iScience, Elsevier BV, Vol. 27, No. 2 ( 2024-02), p. 108979-

Type of Medium: Online Resource

ISSN: 2589-0042

URL: Article

DOI: 10.1016/j.isci.2024.108979

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2927064-9

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Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function

Yang, Zhi-Hong ; Gorusupudi, Aruna ; Lydic, Todd A. ; [et al.]

Elsevier BV ; 2023

In: iScience Vol. 26, No. 12 ( 2023-12), p. 108411-

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In: iScience, Elsevier BV, Vol. 26, No. 12 ( 2023-12), p. 108411-

Type of Medium: Online Resource

ISSN: 2589-0042

URL: Article

DOI: 10.1016/j.isci.2023.108411

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2927064-9

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A reusable polymer supported copper catalyst for the C–N and C–O bond cross-coupling reaction of aryl halides as well as arylboronic acids

Islam, Sk.Manirul ; Mondal, Sanchita ; Mondal, Paramita ; [et al.]

Elsevier BV ; 2012

In: Journal of Organometallic Chemistry Vol. 696, No. 26 ( 2012-01), p. 4264-4274

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In: Journal of Organometallic Chemistry, Elsevier BV, Vol. 696, No. 26 ( 2012-01), p. 4264-4274

Type of Medium: Online Resource

ISSN: 0022-328X

URL: Article

DOI: 10.1016/j.jorganchem.2011.10.004

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1491530-3

detail.hit.zdb_id: 3002-8

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ChemInform Abstract: A Reusable Polymer-Supported Copper Catalyst for the C-N and C-O Bond Cross-Coupling Reaction of Aryl Halides as well as Arylboronic Acids.

Islam, Sk. Manirul ; Mondal, Sanchita ; Mondal, Paramita ; [et al.]

Wiley ; 2012

In: ChemInform Vol. 43, No. 17 ( 2012-04-24), p. no-no

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In: ChemInform, Wiley, Vol. 43, No. 17 ( 2012-04-24), p. no-no

Type of Medium: Online Resource

ISSN: 0931-7597

URL: Issue

URL: Article

DOI: 10.1002/chin.v43.17

DOI: 10.1002/chin.201217043

Language: English

Publisher: Wiley

Publication Date: 2012

detail.hit.zdb_id: 2110203-X

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