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  • 1
    Online Resource
    Online Resource
    Future Medicine Ltd ; 2017
    In:  Epigenomics Vol. 9, No. 1 ( 2017-01), p. 5-12
    In: Epigenomics, Future Medicine Ltd, Vol. 9, No. 1 ( 2017-01), p. 5-12
    Abstract: Aim: Epigenetic comparisons within monozygotic twin pairs have enhanced our understanding of nongenetic mechanisms underlying disease etiology. We present epigenetic findings for a unique case of doubly exchanged Colombian male monozygotic twins raised in extremely different environments. Results: Using genome-wide DNA methylation data from cheek swabs from which blood-specific differentially methylated probes had been removed, the individuals grouped by shared genetics rather than shared environment, except for one twin who presented as an outlier. Closer inspection of DNA methylation differences within both reared-apart twin pairs revealed several genes and genetic pathways likely to be influenced by the rearing environment. Conclusion: Together with our previous findings, we suggest that genetics, pre- and postnatal environments contribute to the epigenetic profile, although additional studies are needed to quantify these effects.
    Type of Medium: Online Resource
    ISSN: 1750-1911 , 1750-192X
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2017
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2019
    In:  Twin Research and Human Genetics Vol. 22, No. 03 ( 2019-06), p. 177-182
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 22, No. 03 ( 2019-06), p. 177-182
    Abstract: This case study examined the hypothesis that longer outdoor time results in normal vision and refractive status, using unique genetically informative kinships. The participants were the members of 29-year-old doubly exchanged monozygotic male twin pairs from Bogotá, Colombia, in South America. Comprehensive ophthalmological examinations, including uncorrected and corrected visual acuity, refraction and keratometry, and visual life history interviews were undertaken; all examinations were conducted by two ophthalmologists blind to the hypothesis, relatedness, and rearing status of the four participants. Normal uncorrected vision and refractive status were present in the two rural-raised, unrelated brothers, relative to their urban-raised counterparts. Uncorrected visual acuities were 20/160 and 20/200 for the city-raised twins and 20/20 and 20/30 for the country-raised twins. Premature birth, low birth weight, computer use, and reading time could not explain these differences. It was concluded that time spent outdoors appears to be a significant factor in the development of myopia, reinforcing extant findings via a novel experimental approach.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2018
    In:  Twin Research and Human Genetics Vol. 21, No. 4 ( 2018-08), p. 295-301
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 21, No. 4 ( 2018-08), p. 295-301
    Abstract: Dr. Irving I. Gottesman was very creative in applying twin research designs to test hypotheses and predictions about human behavior. Two designs stand out among others: twins reared apart from birth and the twin-family study. I (NS) was inspired to incorporate both of these approaches into my own research programs at California State University, Fullerton. Gottesman's involvement and contributions to reared-apart twin research are described, followed by selected findings from the Minnesota Study of Twins Reared Apart (MISTRA), the Fullerton Study of Chinese Twins Reared Apart (CTA), a case report on separated monozygotic (MZ) female twins from South Korea, and doubly exchanged MZ male twin pairs from Colombia, South America. Recent findings from an ongoing twin-family study of social closeness, and future directions, are also presented.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2184274-7
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
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