In:
Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962210796-
Abstract:
COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality. Purpose To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality. Methods Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels 〈 3-fold normal range value [NRV] [500ng/mL] ), Intermediate-values group (D-dimer ≥3-fold and 〈 10-fold NRV) and Higher-value group (≥10-fold NRV). Results 118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables. Conclusions In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients’ survivability and should not be used as a surrogate of disease severity.
Type of Medium:
Online Resource
ISSN:
1076-0296
,
1938-2723
DOI:
10.1177/10760296221079612
Language:
English
Publisher:
SAGE Publications
Publication Date:
2022
detail.hit.zdb_id:
2230591-9
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