In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. suppl_1 ( 2013-05)
Abstract:
“Disappearing HDL Syndrome” refers to cases of acquired severe HDL deficiency in non-critically ill patients. Except for rare idiosyncratic drug reactions, the physiological basis of Disappearing HDL Syndrome is not understood. Hypothesis “Disappearing HDL” in patients with B-cell disorders may be due to increased levels of cytokines, particularly IL-10, in plasma. Methods We investigated cytokine levels in a patient with intravascular large B-cell lymphoma (IVLBCL) who presented with undetectable or very low HDL-C, low LDL-C and markedly elevated triglycerides. IL-10 levels were investigated in additional patients with B-cell disorders (IVLBCL, large B-cell lymphoma, and ALPS) who presented with similar lipid profiles. A direct causal role for IL-10 in modulating HDL-C was investigated with a randomized, placebo-controlled study of recombinant IL-10 infusion into psoriatic arthritis patients. Results All cases (IVLBCL, large B-cell lymphoma and ALPS) had highly elevated serum IL-10 levels that normalized after chemotherapy concomitant with normalization of HDL-C, LDL-C and TG. In a survey of 93 ALPS patients, IL-10 showed a strong inverse correlation with HDL-C (R 2 = 0.3720, p 〈 0.0001). In a randomized, placebo-controlled study of recombinant IL-10 infusion into psoriatic arthritis patients HDL-C precipitously decreased to near-undetectable levels shortly after IL-10 injection. Furthermore, IL-10 treatment also decreased LDL-C by 51% or more during IL-10 administration (p 〈 0.005) and increased TG by up to 2-fold. Conclusions Our study has identified increased IL10 as a potential cause of Disappearing HDL Syndrome and demonstrated that in addition to HDL-C, IL-10 can also modulated levels of LDL-C and TG, thus identifying a new link between inflammation and lipid metabolism.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/atvb.33.suppl_1.A64
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2013
detail.hit.zdb_id:
1494427-3
Bookmarklink
