In:
Postgraduate Medical Journal, Oxford University Press (OUP), Vol. 55, No. 640 ( 1979-02-01), p. 128-134
Abstract:
All human, simian, bovine and avian adenovirus types tested so far and the canine hepatitis virus induce interferon production in chick cells. This finding indicated this property to be characteristic for viruses belonging to the adenovirus group. Trypsin treatment, which had no effect upon the infectivity, diminished or eliminated the interferon-inducing abilities of crude adenoviruses, and thus the need for a trypsin-sensitive protein in interferon induction was suggested. T antigen and interferon were formed simultaneously in chick embryo fibroblast cells infected with human adenovirus type 12, and therefore the adenovirus-specific T antigen was resistant to the action of endogenous interferon synthetized by the same cells. In chicks inoculated with human types, the appearance of interferon was biphasic: an ‘early’ and a ‘late’ interferon could be demonstrated with maximum titre 4 and 10 hr, respectively, after virus infection. In chicks infected with adenoviruses, first interferon production and then a decreased primary immune response to sheep red blood cells was observed. It was assumed that in adenovirus-infected chicks the interferon produced by viral stimulus resulted in a transient immunosuppression.
Type of Medium:
Online Resource
ISSN:
0032-5473
,
1469-0756
DOI:
10.1136/pgmj.55.640.128
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1979
detail.hit.zdb_id:
2009568-5
Bookmarklink