In:
Hepatology Research, Wiley, Vol. 45, No. 9 ( 2015-09), p. 1014-1022
Abstract:
Amino acid transporters play an important role in tumor progression and survival of cancer cells. However, the prognostic significance of L ‐type amino acid transporter 1 ( LAT1 ), system ASC amino acid transporter‐2 ( ASCT2 ) and xCT expression in patients with hepatocellular carcinoma ( HCC ) remains unclear. The aim of this study is to investigate the clinicopathological significance of these amino acid transporters in patients with HCC . Methods We examined 84 patients with surgically resected HCC . Tumor sections were stained by immunohistochemistry for LAT1 , ASCT2 , xCT , 4F2hc / CD98hc ( 4F2hc ), K i‐67 and microvessel density ( MVD ) determined by CD34 . Results LAT1 , 4F2hc , ASCT2 and xCT were positively expressed in 61% (50/84), 77% (65/84), 63% (53/84) and 65% (55/84), respectively. Positive LAT1 expression was significantly associated with 4F2hc expression, K i‐67 and the serum albumin. By univariate analysis, LAT1 expression, disease stage and albumin had a significant relationship with overall survival. Tumor size, disease stage, portal vein invasion, albumin and α‐fetoprotein had a significant relationship with progression‐free survival. Multivariate analysis confirmed that LAT1 expression is an independent and significant prognostic factor for predicting worse outcome after surgery. Conclusion LAT1 can serve as a significant prognostic marker for predicting negative prognosis after surgery.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2006439-1
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