In:
Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 16, No. 3 ( 2019-01-15), p. 238-244
Abstract:
The synthesis of high value risedronic acid is not fully resolved, as, for the time being, the best method based on the preparation from 3-pyridylcarboxylic acid by reaction
with phosphorus trichloride in methanesulfonic acid gives risedronic acid in a good yield, but in an unpure form. Methods: Alternative protocols realizing the synthesis in sulfolane as the solvent and/or in the
presence of suitable IL additive were developed to obtain the target dronic acid in a pure form. Results & Conclusion: Using phosphorus trichloride and phosphorous acid in two equivalents
quantities together with 0.6 equivalents of [bmim] [BF4] without any solvent, the method afforded the target dronic acid in a yield of 66% in a pure form.
Type of Medium:
Online Resource
ISSN:
1570-1808
DOI:
10.2174/1570180815666180626122630
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
SSG:
15,3
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