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1

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Discovery of ( S )-2-Cyclopentyl- N -((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1 H -pyrrido[3,4- b ]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Morris, Lindsey C. ; Nance, Kellie D. ; Gentry, Patrick R. ; [et al.]

American Chemical Society (ACS) ; 2014

In: Journal of Medicinal Chemistry Vol. 57, No. 23 ( 2014-12-11), p. 10192-10197

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 57, No. 23 ( 2014-12-11), p. 10192-10197

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm501375c

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2014

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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2

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Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5d]pyrimidine-2,4(1H,3H)dione Core

Nance, Kellie D. ; Days, Emily L. ; Weaver, C. David ; [et al.]

American Chemical Society (ACS) ; 2017

In: Journal of Medicinal Chemistry Vol. 60, No. 4 ( 2017-02-23), p. 1611-1616

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 60, No. 4 ( 2017-02-23), p. 1611-1616

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.6b01706

DOI: 10.1021/acs.jmedchem.6b01706.s001

DOI: 10.1021/acs.jmedchem.6b01706.s002

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2017

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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3

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Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

Panarese, Joseph D. ; Cho, Hykeyung P. ; Adams, Jeffrey J. ; [et al.]

Elsevier BV ; 2016

In: Bioorganic & Medicinal Chemistry Letters Vol. 26, No. 15 ( 2016-08), p. 3822-3825

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 26, No. 15 ( 2016-08), p. 3822-3825

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2016.04.083

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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4

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Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation

Shrimp, Jonathan H. ; Jing, Yihang ; Gamage, Supuni Thalalla ; [et al.]

American Chemical Society (ACS) ; 2021

In: ACS Medicinal Chemistry Letters Vol. 12, No. 6 ( 2021-06-10), p. 887-892

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In: ACS Medicinal Chemistry Letters, American Chemical Society (ACS), Vol. 12, No. 6 ( 2021-06-10), p. 887-892

Type of Medium: Online Resource

ISSN: 1948-5875 , 1948-5875

URL: Article

DOI: 10.1021/acsmedchemlett.0c00193

DOI: 10.1021/acsmedchemlett.0c00193.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2021

detail.hit.zdb_id: 2532386-6

SSG: 15,3

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5

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A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks

Levy, Michaella J. ; Montgomery, David C. ; Sardiu, Mihaela E. ; [et al.]

Elsevier BV ; 2020

In: Cell Chemical Biology Vol. 27, No. 3 ( 2020-03), p. 322-333.e5

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In: Cell Chemical Biology, Elsevier BV, Vol. 27, No. 3 ( 2020-03), p. 322-333.e5

Type of Medium: Online Resource

ISSN: 2451-9456

URL: Article

DOI: 10.1016/j.chembiol.2019.11.011

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2850144-5

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6

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Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256

Grannan, Michael D. ; Mielnik, Catharine A. ; Moran, Sean P. ; [et al.]

American Chemical Society (ACS) ; 2016

In: ACS Chemical Neuroscience Vol. 7, No. 12 ( 2016-12-21), p. 1706-1716

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In: ACS Chemical Neuroscience, American Chemical Society (ACS), Vol. 7, No. 12 ( 2016-12-21), p. 1706-1716

Type of Medium: Online Resource

ISSN: 1948-7193 , 1948-7193

URL: Article

DOI: 10.1021/acschemneuro.6b00230

DOI: 10.1021/acschemneuro.6b00230.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2016

detail.hit.zdb_id: 2528493-9

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7

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The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core

Bertron, Jeanette L. ; Cho, Hyekyung P. ; Garcia-Barrantes, Pedro M. ; [et al.]

Elsevier BV ; 2018

In: Bioorganic & Medicinal Chemistry Letters Vol. 28, No. 12 ( 2018-07), p. 2175-2179

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 28, No. 12 ( 2018-07), p. 2175-2179

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2018.05.009

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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8

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A Chemical Signature for Cytidine Acetylation in RNA

Thomas, Justin M. ; Briney, Chloe A. ; Nance, Kellie D. ; [et al.]

American Chemical Society (ACS) ; 2018

In: Journal of the American Chemical Society Vol. 140, No. 40 ( 2018-10-10), p. 12667-12670

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In: Journal of the American Chemical Society, American Chemical Society (ACS), Vol. 140, No. 40 ( 2018-10-10), p. 12667-12670

Type of Medium: Online Resource

ISSN: 0002-7863 , 1520-5126

URL: Article

DOI: 10.1021/jacs.8b06636

DOI: 10.1021/jacs.8b06636.s002

RVK:

VA 1120 ; VA 1752

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2018

detail.hit.zdb_id: 1472210-0

detail.hit.zdb_id: 3155-0

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9

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Total synthesis of natural (−)- and unnatural (+)-Melearoride A

Reed, Carson W. ; Fulton, Mark G. ; Nance, Kellie D. ; [et al.]

Elsevier BV ; 2019

In: Tetrahedron Letters Vol. 60, No. 10 ( 2019-03), p. 743-745

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In: Tetrahedron Letters, Elsevier BV, Vol. 60, No. 10 ( 2019-03), p. 743-745

Type of Medium: Online Resource

ISSN: 0040-4039

URL: Article

DOI: 10.1016/j.tetlet.2019.02.006

RVK:

VA 7560

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2007074-3

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10

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Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes

Geanes, Alexander R. ; Cho, Hykeyung P. ; Nance, Kellie D. ; [et al.]

Elsevier BV ; 2016

In: Bioorganic & Medicinal Chemistry Letters Vol. 26, No. 18 ( 2016-09), p. 4487-4491

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 26, No. 18 ( 2016-09), p. 4487-4491

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2016.07.071

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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