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Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial

Koekenbier, Eva L. ; Fohse, Konstantin ; van de Maat, Josephine S. ; [et al.]

Elsevier BV ; 2023

In: Clinical Microbiology and Infection Vol. 29, No. 6 ( 2023-06), p. 781-788

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In: Clinical Microbiology and Infection, Elsevier BV, Vol. 29, No. 6 ( 2023-06), p. 781-788

Type of Medium: Online Resource

ISSN: 1198-743X

URL: Article

DOI: 10.1016/j.cmi.2023.01.019

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2020034-1

SSG: 12

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Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Kyriazopoulou, Evdoxia ; Huet, Thomas ; Cavalli, Giulio ; [et al.]

Elsevier BV ; 2021

In: The Lancet Rheumatology Vol. 3, No. 10 ( 2021-10), p. e690-e697

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In: The Lancet Rheumatology, Elsevier BV, Vol. 3, No. 10 ( 2021-10), p. e690-e697

Type of Medium: Online Resource

ISSN: 2665-9913

URL: Article

DOI: 10.1016/S2665-9913(21)00216-2

Language: English

Publisher: Elsevier BV

Publication Date: 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J ; Abdelmohsen, Kotb ; Abe, Akihisa ; [et al.]

Informa UK Limited ; 2016

In: Autophagy Vol. 12, No. 1 ( 2016-01-02), p. 1-222

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In: Autophagy, Informa UK Limited, Vol. 12, No. 1 ( 2016-01-02), p. 1-222

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2015.1100356

Language: English

Publisher: Informa UK Limited

Publication Date: 2016

detail.hit.zdb_id: 2262043-6

SSG: 12

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Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage

Hervella, Montserrat ; Rotea, Mihai ; Izagirre, Neskuts ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 6 ( 2015-6-8), p. e0128810-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 6 ( 2015-6-8), p. e0128810-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0128810

DOI: 10.1371/journal.pone.0128810.g001

DOI: 10.1371/journal.pone.0128810.g002

DOI: 10.1371/journal.pone.0128810.g003

DOI: 10.1371/journal.pone.0128810.t001

DOI: 10.1371/journal.pone.0128810.t002

DOI: 10.1371/journal.pone.0128810.s001

DOI: 10.1371/journal.pone.0128810.s002

DOI: 10.1371/journal.pone.0128810.s003

DOI: 10.1371/journal.pone.0128810.s004

DOI: 10.1371/journal.pone.0128810.s005

DOI: 10.1371/journal.pone.0128810.s006

DOI: 10.1371/journal.pone.0128810.s007

DOI: 10.1371/journal.pone.0128810.s008

DOI: 10.1371/journal.pone.0128810.s009

DOI: 10.1371/journal.pone.0128810.s010

DOI: 10.1371/journal.pone.0128810.s011

DOI: 10.1371/journal.pone.0128810.s012

DOI: 10.1371/journal.pone.0128810.s013

DOI: 10.1371/journal.pone.0128810.s014

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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Genetic continuity, isolation, and gene flow in Stone Age Central and Eastern Europe

Mattila, Tiina M. ; Svensson, Emma M. ; Juras, Anna ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Communications Biology Vol. 6, No. 1 ( 2023-08-09)

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In: Communications Biology, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2023-08-09)

Abstract: The genomic landscape of Stone Age Europe was shaped by multiple migratory waves and population replacements, but different regions do not all show similar patterns. To refine our understanding of the population dynamics before and after the dawn of the Neolithic, we generated and analyzed genomic sequence data from human remains of 56 individuals from the Mesolithic, Neolithic, and Eneolithic across Central and Eastern Europe. We found that Mesolithic European populations formed a geographically widespread isolation-by-distance zone ranging from Central Europe to Siberia, which was already established 10,000 years ago. We found contrasting patterns of population continuity during the Neolithic transition: people around the lower Dnipro Valley region, Ukraine, showed continuity over 4000 years, from the Mesolithic to the end of the Neolithic, in contrast to almost all other parts of Europe where population turnover drove this cultural change, including vast areas of Central Europe and around the Danube River.

Type of Medium: Online Resource

ISSN: 2399-3642

URL: Article

DOI: 10.1038/s42003-023-05131-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2919698-X

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Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways

Tesselaar, Marika H. ; Crezee, Thomas ; Swarts, Herman G. ; [et al.]

American Association for Cancer Research (AACR) ; 2017

In: Molecular Cancer Therapeutics Vol. 16, No. 1 ( 2017-01-01), p. 169-181

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In: Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 16, No. 1 ( 2017-01-01), p. 169-181

Abstract: Up to 20%–30% of patients with metastatic non-medullary thyroid cancer have persistent or recurrent disease resulting from tumor dedifferentiation. Tumor redifferentiation to restore sensitivity to radioactive iodide (RAI) therapy is considered a promising strategy to overcome RAI resistance. Autophagy has emerged as an important mechanism in cancer dedifferentiation. Here, we demonstrate the therapeutic potential of autophagy activators for redifferentiation of thyroid cancer cell lines. Five autophagy-activating compounds, all known as digitalis-like compounds, restored hNIS expression and iodide uptake in thyroid cancer cell lines. Upregulation of hNIS was mediated by intracellular Ca2+ and FOS activation. Cell proliferation was inhibited by downregulating AKT1 and by induction of autophagy and p21-dependent cell-cycle arrest. Digitalis-like compounds, also designated as cardiac glycosides for their well-characterized beneficial effects in the treatment of heart disease, could therefore represent a promising repositioned treatment modality for patients with RAI-refractory thyroid carcinoma. Mol Cancer Ther; 16(1); 169–81. ©2016 AACR.

Type of Medium: Online Resource

ISSN: 1535-7163 , 1538-8514

URL: Article

DOI: 10.1158/1535-7163.MCT-16-0460

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2017

detail.hit.zdb_id: 2062135-8

SSG: 12

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Host and Environmental Factors Influencing Individual Human Cytokine Responses

ter Horst, Rob ; Jaeger, Martin ; Smeekens, Sanne P. ; [et al.]

Elsevier BV ; 2016

In: Cell Vol. 167, No. 4 ( 2016-11), p. 1111-1124.e13

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In: Cell, Elsevier BV, Vol. 167, No. 4 ( 2016-11), p. 1111-1124.e13

Type of Medium: Online Resource

ISSN: 0092-8674

URL: Article

DOI: 10.1016/j.cell.2016.10.018

RVK:

XA 36269

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 187009-9

detail.hit.zdb_id: 2001951-8

SSG: 12

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mTOR Inhibition Promotes TTF1-Dependent Redifferentiation and Restores Iodine Uptake in Thyroid Carcinoma Cell Lines

Plantinga, Theo S. ; Heinhuis, Bas ; Gerrits, Danny ; [et al.]

The Endocrine Society ; 2014

In: The Journal of Clinical Endocrinology & Metabolism Vol. 99, No. 7 ( 2014-07-01), p. E1368-E1375

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In: The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society, Vol. 99, No. 7 ( 2014-07-01), p. E1368-E1375

Type of Medium: Online Resource

ISSN: 0021-972X , 1945-7197

URL: Article

DOI: 10.1210/jc.2014-1171

RVK:

XA 10000

Language: English

Publisher: The Endocrine Society

Publication Date: 2014

detail.hit.zdb_id: 2026217-6

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Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

Aguirre-Gamboa, Raul ; Joosten, Irma ; Urbano, Paulo C.M. ; [et al.]

Elsevier BV ; 2016

In: Cell Reports Vol. 17, No. 9 ( 2016-11), p. 2474-2487

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In: Cell Reports, Elsevier BV, Vol. 17, No. 9 ( 2016-11), p. 2474-2487

Type of Medium: Online Resource

ISSN: 2211-1247

URL: Article

DOI: 10.1016/j.celrep.2016.10.053

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2649101-1

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Correction to: Origins, admixture and founder lineages in European Roma

Martínez-Cruz, Begoña ; Mendizabal, Isabel ; Harmant, Christine ; [et al.]

Springer Science and Business Media LLC ; 2022

In: European Journal of Human Genetics Vol. 30, No. 4 ( 2022-04), p. 490-490

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In: European Journal of Human Genetics, Springer Science and Business Media LLC, Vol. 30, No. 4 ( 2022-04), p. 490-490

Type of Medium: Online Resource

ISSN: 1018-4813 , 1476-5438

URL: Article

DOI: 10.1038/s41431-021-01020-7

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2005160-8

SSG: 12

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