In:
Proceedings of the Bulgarian Academy of Sciences, Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences), Vol. 75, No. 11 ( 2022-11-30), p. 1672-1679
Abstract:
The aim of the present study was to estimate 1) whether the endogenous cannabinoid and the nitric oxide-ergic systems' interaction affects cold stress-induced analgesia (c-SIA), and 2) whether the possible interaction (and its impact on c-SIA) differs before and after cold-stress exposure. Male Wistar rats have been injected with CB1-receptor agonist anandamide (AEA) and the nitric oxide (NO) precursor L-arginine before and after 1 hour of cold stress (1 h CS) exposure; CB1 antagonist AM251, the nitric oxide synthase inhibitor L-NAME, and the NO-donor SIN-1 were additionally applied in order to further elucidate the interaction between the two systems. Results obtained suggest that endocannabinoids and NO differently interact before and after stress: applied before stress, the two systems were antagonistic between them with AEA exerting an analgesic effect, while NO decreased analgesia; a synergistic effect of endocannabinoids and NO resulted instead in application after 1 h CS.
Type of Medium:
Online Resource
ISSN:
2367-5535
,
1310-1331
DOI:
10.7546/CRABS.2022.11.15
Language:
Unknown
Publisher:
Prof. Marin Drinov Publishing House of BAS (Bulgarian Academy of Sciences)
Publication Date:
2022
detail.hit.zdb_id:
2435977-4
SSG:
11
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