In:
Advanced Synthesis & Catalysis, Wiley, Vol. 360, No. 15 ( 2018-08-06), p. 2813-2819
Abstract:
N ‐Heteroaromatic substituted acrylates are employed in the phosphine‐catalyzed [3+2] annulation with allenes for the first time, affording regiospecific carbocyclic nucleoside analogues in an α‐addition manner. Various chiral carbocyclic nucleoside analogues containing a quaternary stereocenter and a C=C double bond are generated in good yields (up to 90% yield) and excellent enantioselectivities (up to 97% ee). α‐Purine‐containing disubstituted acrylate and α‐benzimidazole substituted acrylate are also suitable substrates for this reaction. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v360.15
DOI:
10.1002/adsc.201800523
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
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