In:
ChemistrySelect, Wiley, Vol. 5, No. 5 ( 2020-02-07), p. 1623-1627
Abstract:
The early detection of cancer cells and their visualization before and after surgery are essential for successful pre‐ and post‐operative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumour‐targeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes ( 1 : Et 2 N−L‐SnPh 2 , 2 : Et 2 N−L‐SnBu 2 , 3 : MeO−L‐SnPh 2 , 4 : MeO−L‐SnBu 2 , 5 : HO−L‐SnPh 2 , and 6 : HO−L‐SnBu 2 , where L=2‐hydroxybenzylidene‐4‐hydroxybenzhydrazine). In addition to one‐photon‐excited fluorescence, efficient two‐photon excitation was demonstrated in compounds 1 – 4 . Two of the compounds ( 5 and 6 ), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using two‐photon bioimaging, which is promising for biomedicine applications.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201904816
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2844262-3
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