KOBV Portal

Online Resource

Hepatic stearoyl-CoA desaturase-1 deficiency induces fibrosis and hepatocellular carcinoma-related gene activation under a high carbohydrate low fat diet

Ntambi, Jayne-Norah ; Kalyesubula, Mugagga ; Cootway, Dylan ; [et al.]

Elsevier BV ; 2024

In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ( 2024-7), p. 159538-

add to watchlist on the watchlist

Details

In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Elsevier BV, ( 2024-7), p. 159538-

Type of Medium: Online Resource

ISSN: 1388-1981

URL: Article

DOI: 10.1016/j.bbalip.2024.159538

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2209502-0

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

Liu, Sihao ; Hatano, Ben ; Zhao, Minghui ; [et al.]

Elsevier BV ; 2011

In: Journal of Biological Chemistry Vol. 286, No. 2 ( 2011-01), p. 1237-1247

add to watchlist on the watchlist

Details

In: Journal of Biological Chemistry, Elsevier BV, Vol. 286, No. 2 ( 2011-01), p. 1237-1247

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M110.138115

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

PGC‐1a integrates a metabolism and growth network linked to caloric restriction

Miller, Karl N. ; Clark, Josef P. ; Martin, Stephen A. ; [et al.]

Wiley ; 2019

In: Aging Cell Vol. 18, No. 5 ( 2019-10)

add to watchlist on the watchlist

Details

In: Aging Cell, Wiley, Vol. 18, No. 5 ( 2019-10)

Abstract: Deleterious changes in energy metabolism have been linked to aging and disease vulnerability, while activation of mitochondrial pathways has been linked to delayed aging by caloric restriction (CR). The basis for these associations is poorly understood, and the scope of impact of mitochondrial activation on cellular function has yet to be defined. Here, we show that mitochondrial regulator PGC‐1a is induced by CR in multiple tissues, and at the cellular level, CR‐like activation of PGC‐1a impacts a network that integrates mitochondrial status with metabolism and growth parameters. Transcriptional profiling reveals that diverse functions, including immune pathways, growth, structure, and macromolecule homeostasis, are responsive to PGC‐1a. Mechanistically, these changes in gene expression were linked to chromatin remodeling and RNA processing. Metabolic changes implicated in the transcriptional data were confirmed functionally including shifts in NAD metabolism, lipid metabolism, and membrane lipid composition. Delayed cellular proliferation, altered cytoskeleton, and attenuated growth signaling through post‐transcriptional and post‐translational mechanisms were also identified as outcomes of PGC‐1a‐directed mitochondrial activation. Furthermore, in vivo in tissues from a genetically heterogeneous mouse population, endogenous PGC‐1a expression was correlated with this same metabolism and growth network. These data show that small changes in metabolism have broad consequences that arguably would profoundly alter cell function. We suggest that this PGC‐1a sensitive network may be the basis for the association between mitochondrial function and aging where small deficiencies precipitate loss of function across a spectrum of cellular activities.

Type of Medium: Online Resource

ISSN: 1474-9718 , 1474-9726

URL: Issue

URL: Article

DOI: 10.1111/acel.v18.5

DOI: 10.1111/acel.12999

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2099130-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Presence of a bent helix in fragments of kinetoplast DNA minicircles from several trypanosomatid species

Ntambi, James M. ; Marini, Joan C. ; Bangs, James D. ; [et al.]

Elsevier BV ; 1984

In: Molecular and Biochemical Parasitology Vol. 12, No. 3 ( 1984-7), p. 273-286

add to watchlist on the watchlist

Details

In: Molecular and Biochemical Parasitology, Elsevier BV, Vol. 12, No. 3 ( 1984-7), p. 273-286

Type of Medium: Online Resource

ISSN: 0166-6851

URL: Article

DOI: 10.1016/0166-6851(84)90084-7

Language: English

Publisher: Elsevier BV

Publication Date: 1984

detail.hit.zdb_id: 1491098-6

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Differential Effects of Dietary Fat Content and Protein Source on Bone Phenotype and Fatty Acid Oxidation in Female C57Bl/6 Mice

Sawin, Emily A. ; Stroup, Bridget M. ; Murali, Sangita G. ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 10 ( 2016-10-3), p. e0163234-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 10 ( 2016-10-3), p. e0163234-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0163234

DOI: 10.1371/journal.pone.0163234.g001

DOI: 10.1371/journal.pone.0163234.g002

DOI: 10.1371/journal.pone.0163234.g003

DOI: 10.1371/journal.pone.0163234.g004

DOI: 10.1371/journal.pone.0163234.g005

DOI: 10.1371/journal.pone.0163234.g006

DOI: 10.1371/journal.pone.0163234.g007

DOI: 10.1371/journal.pone.0163234.g008

DOI: 10.1371/journal.pone.0163234.g009

DOI: 10.1371/journal.pone.0163234.g010

DOI: 10.1371/journal.pone.0163234.g011

DOI: 10.1371/journal.pone.0163234.g012

DOI: 10.1371/journal.pone.0163234.g013

DOI: 10.1371/journal.pone.0163234.t001

DOI: 10.1371/journal.pone.0163234.t002

DOI: 10.1371/journal.pone.0163234.t003

DOI: 10.1371/journal.pone.0163234.t004

DOI: 10.1371/journal.pone.0163234.t005

DOI: 10.1371/journal.pone.0163234.t006

DOI: 10.1371/journal.pone.0163234.t007

DOI: 10.1371/journal.pone.0163234.t008

DOI: 10.1371/journal.pone.0163234.t009

DOI: 10.1371/journal.pone.0163234.s001

DOI: 10.1371/journal.pone.0163234.s002

DOI: 10.1371/journal.pone.0163234.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation

Burhans, Maggie S. ; Flowers, Matthew T. ; Harrington, Kristin R. ; [et al.]

Elsevier BV ; 2015

In: Journal of Lipid Research Vol. 56, No. 2 ( 2015-02), p. 304-318

add to watchlist on the watchlist

Details

In: Journal of Lipid Research, Elsevier BV, Vol. 56, No. 2 ( 2015-02), p. 304-318

Type of Medium: Online Resource

ISSN: 0022-2275

URL: Article

DOI: 10.1194/jlr.M054429

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1466675-3

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids

Miller, Karl N. ; Burhans, Maggie S. ; Clark, Josef P. ; [et al.]

Wiley ; 2017

In: Aging Cell Vol. 16, No. 3 ( 2017-06), p. 497-507

add to watchlist on the watchlist

Details

In: Aging Cell, Wiley, Vol. 16, No. 3 ( 2017-06), p. 497-507

Type of Medium: Online Resource

ISSN: 1474-9718

URL: Article

DOI: 10.1111/acel.12575

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2099130-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Contribution of Stearoyl-CoA Desaturase Expression to Exercise Capacity, Muscle Lipid Composition, and De Novo Lipogenesis : 726 June 3 9:30 AM - 9:45 AM

Paton, Chad M. ; Schiesser, Kevin J. ; Flowers, Matthew T. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2010

In: Medicine & Science in Sports & Exercise Vol. 42, No. 5 ( 2010-05), p. 44-

add to watchlist on the watchlist

Details

In: Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 5 ( 2010-05), p. 44-

Type of Medium: Online Resource

ISSN: 0195-9131

URL: Article

DOI: 10.1249/01.MSS.0000384902.20012.3d

RVK:

ZX 1000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2010

detail.hit.zdb_id: 2031167-9

SSG: 31

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

Hulver, Matthew W. ; Berggren, Jason R. ; Carper, Michael J. ; [et al.]

Elsevier BV ; 2005

In: Cell Metabolism Vol. 2, No. 4 ( 2005-10), p. 251-261

add to watchlist on the watchlist

Details

In: Cell Metabolism, Elsevier BV, Vol. 2, No. 4 ( 2005-10), p. 251-261

Type of Medium: Online Resource

ISSN: 1550-4131

URL: Article

DOI: 10.1016/j.cmet.2005.09.002

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 2174469-5

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells

Choi, Youngjin ; Park, Yeonhwa ; Storkson, Jayne M ; [et al.]

Elsevier BV ; 2002

In: Biochemical and Biophysical Research Communications Vol. 294, No. 4 ( 2002-06), p. 785-790

add to watchlist on the watchlist

Details

In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 294, No. 4 ( 2002-06), p. 785-790

Type of Medium: Online Resource

ISSN: 0006-291X

URL: Article

DOI: 10.1016/S0006-291X(02)00554-5

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2002

detail.hit.zdb_id: 1461396-7

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 194 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg