KOBV Portal

Hits per page

hits 1 - 10 | 255 hits

Sorting

Online Resource

Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study

Lee, Michael S ; Ryoo, Baek-Yeol ; Hsu, Chih-Hung ; [et al.]

Elsevier BV ; 2020

In: The Lancet Oncology Vol. 21, No. 6 ( 2020-06), p. 808-820

add to watchlist on the watchlist

Details

In: The Lancet Oncology, Elsevier BV, Vol. 21, No. 6 ( 2020-06), p. 808-820

Type of Medium: Online Resource

ISSN: 1470-2045

URL: Article

DOI: 10.1016/S1470-2045(20)30156-X

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2049730-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trial

Kondo, Masaaki ; Morimoto, Manabu ; Kobayashi, Satoshi ; [et al.]

Springer Science and Business Media LLC ; 2019

In: BMC Cancer Vol. 19, No. 1 ( 2019-12)

add to watchlist on the watchlist

Details

In: BMC Cancer, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2019-12)

Abstract: The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing a sequential HAIC-sorafenib regimen versus sorafenib alone as an initial therapy for HCC. Methods Patients were randomly assigned (ratio, 1:1) to receive sequential HAIC with cisplatin followed by sorafenib (HAIC group, n = 35) or sorafenib alone (sorafenib group, n = 33) as an initial therapy. The primary endpoint was the one-year survival rate. Secondary endpoint included overall survival (OS), the 2-year survival rate, the time-to-progression (TTP), the objective response rate (ORR), the disease control rate (DCR), and safety. Results For the primary endpoint, the one-year survival rates were 46% in the HAIC group and 58% in the sorafenib group. The median OS period was 10.0 months (95% CI, 7.0–18.8) in the HAIC group and 15.2 months (95% CI, 8.2–19.7) in the sorafenib group (hazard ratio [HR], 1.08; 95% CI, 0.63 to 1.86, P = 0.78). The median TTP, ORR and DCR in the HAIC group were 2.8 months (95% CI, 1.7–5.5), 14.3, and 45.7%, respectively, while those in the sorafenib group were 3.9 months (95% CI, 2.3–6.8), 9.1, and 45.5%, respectively. No unexpected adverse events related to HAIC or sorafenib were observed in either group. Conclusions Sequential HAIC with cisplatin and sorafenib does not improve the survival benefit, compared with sorafenib alone, when used as an initial therapy for advanced HCC. However, this study was underpowered in regard to its primary and secondary endpoints, so the results should be interpreted with caution. Trial registration UMIN ID 000006147 , registration data: August 11, 2011.

Type of Medium: Online Resource

ISSN: 1471-2407

URL: Article

DOI: 10.1186/s12885-019-6198-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2041352-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Optimal application of stereotactic body radiotherapy and radiofrequency ablation treatment for different multifocal hepatocellular carcinoma lesions in patients with Barcelona Clinic Liver Cancer stage A4–B1: a pilot study

Wang, Feiqian ; Numata, Kazushi ; Takeda, Atsuya ; [et al.]

Springer Science and Business Media LLC ; 2021

In: BMC Cancer Vol. 21, No. 1 ( 2021-12)

add to watchlist on the watchlist

Details

In: BMC Cancer, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)

Abstract: In clinical practice, many hepatocellular carcinoma (HCC) patients in Barcelona Clinical Liver Cancer (BCLC) stage A4–B1 cannot receive the curative treatments of liver transplantation, resection, and radiofrequency ablation (RFA), which are the recommended options according to liver cancer guidelines. Our aim is to study the feasibility of RFA and stereotactic body radiotherapy (SBRT) as a curative treatment for different multifocal HCCs in BCLC stage A4–B1 patients. Methods From September 2014 to August 2019, 39 multifocal HCC lesions (median diameter: 16.6 mm) from 15 patients (median age: 73 years) were retrospectively selected. Among them, 23 were treated by RFA and the other 16 by SBRT because of predictable insufficiency and/or risk related to RFA performance. The indicators for evaluating this novel therapy were the tumor response, prognosis (recurrence and survival), and adverse effects (deterioration of laboratory test values and severe complications). Results The median follow-up duration was 31.3 months (range: 15.1–71.9 months). The total patients with a one-year complete response, stable disease, or disease progression were 11, 1, and 3, respectively. In total, 8 and 2 patients had confronted intrahepatic or local recurrence, respectively. The one-year progression-free survival rate and local control rate were 80% (12/15 patients) and 97.4% (38/39 lesions), respectively. The median time to progression was 20.1 (2.8–45.1) months. The one- and two-year survival rates were 100 and 88.9%, respectively. In up to five months’ observation, no patient showed severe complications. Seven, four, and two patients had slight changes in their white blood cells, platelet count, or albumin–bilirubin grade, respectively. Conclusions For patients with BCLC stage A4–B1, RFA and SBRT treatment for different multifocal HCCs may be a potential option because of the favorable prognosis and safety. However, before its application in clinical practice, prospective, controlled, large-scale studies are needed to further confirm our conclusions.

Type of Medium: Online Resource

ISSN: 1471-2407

URL: Article

DOI: 10.1186/s12885-021-08897-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2041352-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Sa1082 Color Doppler Ultrasound Is Sensitive Nonionizing Technique to Evaluate Active Crohn's Disease

Shibata, Wataru ; Kunisaki, Reiko ; Sasaki, Tomohiko ; [et al.]

Elsevier BV ; 2013

In: Gastroenterology Vol. 144, No. 5 ( 2013-05), p. S-197-

add to watchlist on the watchlist

Details

In: Gastroenterology, Elsevier BV, Vol. 144, No. 5 ( 2013-05), p. S-197-

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1016/S0016-5085(13)60691-5

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2013

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Su1179 Differential Diagnosis of Polypoid Lesions of the Gallbladder Using Contrast-Enhanced Ultrasonography With High Mechanical Index Contrast Mode

Miwa, Haruo ; Numata, Kazushi ; Ishii, Tomohiro ; [et al.]

Elsevier BV ; 2015

In: Gastroenterology Vol. 148, No. 4 ( 2015-04), p. S-429-

add to watchlist on the watchlist

Details

In: Gastroenterology, Elsevier BV, Vol. 148, No. 4 ( 2015-04), p. S-429-

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1016/S0016-5085(15)31450-5

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2015

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Optimal flip angle of Gd-EOB-DTPA-enhanced MRI in patients with hepatocellular carcinoma and liver metastasis

Okada, Masahiro ; Wakayama, Tetsuya ; Yada, Norihisa ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Abdominal Imaging Vol. 39, No. 4 ( 2014-8), p. 694-701

add to watchlist on the watchlist

Details

In: Abdominal Imaging, Springer Science and Business Media LLC, Vol. 39, No. 4 ( 2014-8), p. 694-701

Type of Medium: Online Resource

ISSN: 0942-8925 , 1432-0509

URL: Article

DOI: 10.1007/s00261-014-0096-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2845742-0

detail.hit.zdb_id: 1462117-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

超音波診断における音響陰影を考慮した自動プローブ操作モデルの提案

MATSUYAMA, Momoko ; KOIZUMI, Norihiro ; NISHIYAMA, Yu ; [et al.]

Japan Society of Mechanical Engineers ; 2022

In: The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) Vol. 2022, No. 0 ( 2022), p. 1P1-M11-

add to watchlist on the watchlist

Details

In: The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), Japan Society of Mechanical Engineers, Vol. 2022, No. 0 ( 2022), p. 1P1-M11-

Type of Medium: Online Resource

ISSN: 2424-3124

URL: Article

DOI: 10.1299/jsmermd.2022.1P1-M11

Language: English

Publisher: Japan Society of Mechanical Engineers

Publication Date: 2022

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Facilitation of liver regeneration after partial hepatectomy by ventromedial hypothalamic lesions in rats

Kiba, Takayoshi ; Tanaka, Katsuaki ; Numata, Kazushi ; [et al.]

Springer Science and Business Media LLC ; 1994

In: Pfl�gers Archiv European Journal of Physiology Vol. 428, No. 1 ( 1994-8), p. 26-29

add to watchlist on the watchlist

Details

In: Pfl�gers Archiv European Journal of Physiology, Springer Science and Business Media LLC, Vol. 428, No. 1 ( 1994-8), p. 26-29

Type of Medium: Online Resource

ISSN: 0031-6768 , 1432-2013

URL: Article

DOI: 10.1007/BF00374748

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 1994

detail.hit.zdb_id: 1463014-X

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Safety and efficacy study: Short-term application of radiofrequency ablation and stereotactic body radiotherapy for Barcelona Clinical Liver Cancer stage 0–B1 hepatocellular carcinoma

Wang, Feiqian ; Numata, Kazushi ; Takeda, Atsuya ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 1 ( 2021-1-5), p. e0245076-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-5), p. e0245076-

Abstract: To evaluate the safety and efficacy of the administration of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in the short term to the same patients in Barcelona Clinical Liver Cancer (BCLC) stages 0–B1. Methods From April 2014 to June 2019, we retrospectively reviewed BCLC stage 0–B1 patients with fresh hepatocellular carcinoma (HCC) lesions that were repeatedly treated by RFA (control group, n = 72), and by RFA and subsequent SBRT (case group, n = 26). Propensity score matching (PSM) was performed to reduce the selection bias between two groups. Recurrence, survival, Child–Pugh scores and short-term side effects (fever, bleeding, skin change, abdominal pain and fatigue) were recorded and analyzed. Results After PSM, 21 patients remained in each group. Seventeen and 20 patients in the case and control groups experienced recurrence. For these patients, the median times to progression and follow-up were 10.7 and 35.8 months, respectively. After PSM, the 1-year progression-free survival rate in case and control groups were 66.7% and 52.4%, respectively (P = 0.313). The inter-group overall survival (OS) was comparable (3 and 5-year OS rates in case groups were 87.3% and 74.8%, while rates in control groups were 73.7% and 46.3%, respectively; P = 0.090). The short-term side effects were mild, and the incidence showed no inter-group difference. The 1-year rates of the Child–Pugh score deterioration of ≥2 in case and control groups were 23.8% and 33.3% ( P 〉 0.05), respectively. Conclusion The short-term administration of RFA and SBRT to the same BCLC stage 0–B1 patients may be feasible and effective because of their good prognosis and safety.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0245076

DOI: 10.1371/journal.pone.0245076.g001

DOI: 10.1371/journal.pone.0245076.g002

DOI: 10.1371/journal.pone.0245076.g003

DOI: 10.1371/journal.pone.0245076.t001

DOI: 10.1371/journal.pone.0245076.t002

DOI: 10.1371/journal.pone.0245076.t003

DOI: 10.1371/journal.pone.0245076.s001

DOI: 10.1371/journal.pone.0245076.s002

DOI: 10.1371/journal.pone.0245076.r001

DOI: 10.1371/journal.pone.0245076.r002

DOI: 10.1371/journal.pone.0245076.r003

DOI: 10.1371/journal.pone.0245076.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

1. Diagnosis of Hepatocellular Carcinoma by Ultrasonography

Numata, Kazushi ; Tanaka, Katsuaki

Japanese Society of Internal Medicine ; 2014

In: Nihon Naika Gakkai Zasshi Vol. 103, No. 1 ( 2014), p. 44-54

add to watchlist on the watchlist

Details

In: Nihon Naika Gakkai Zasshi, Japanese Society of Internal Medicine, Vol. 103, No. 1 ( 2014), p. 44-54

Type of Medium: Online Resource

ISSN: 0021-5384 , 1883-2083

Uniform Title: 1．超音波診断

URL: Article

DOI: 10.2169/naika.103.44

Language: English , Japanese

Publisher: Japanese Society of Internal Medicine

Publication Date: 2014

detail.hit.zdb_id: 2455995-7

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 255 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg