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  • 1
    In: Beilstein Journal of Nanotechnology, Beilstein Institut, Vol. 7 ( 2016-07-04), p. 957-969
    Abstract: Background: In nanoscale layered S/F 1 /N/F 2 /AF heterostructures, the generation of a long-range, odd-in-frequency spin-projection one triplet component of superconductivity, arising at non-collinear alignment of the magnetizations of F 1 and F 2 , exhausts the singlet state. This yields the possibility of a global minimum of the superconducting transition temperature T c , i.e., a superconducting triplet spin-valve effect, around mutually perpendicular alignment. Results: The superconducting triplet spin valve is realized with S = Nb a singlet superconductor, F 1 = Cu 41 Ni 59 and F 2 = Co ferromagnetic metals, AF = CoO x an antiferromagnetic oxide, and N = nc-Nb a normal conducting (nc) non-magnetic metal, which serves to decouple F 1 and F 2 . The non-collinear alignment of the magnetizations is obtained by applying an external magnetic field parallel to the layers of the heterostructure and exploiting the intrinsic perpendicular easy-axis of the magnetization of the Cu 41 Ni 59 thin film in conjunction with the exchange bias between CoO x and Co. The magnetic configurations are confirmed by superconducting quantum interference device (SQUID) magnetic moment measurements. The triplet spin-valve effect has been investigated for different layer thicknesses, d F1 , of F 1 and was found to decay with increasing d F1 . The data is described by an empirical model and, moreover, by calculations using the microscopic theory. Conclusion: The long-range triplet component of superconducting pairing is generated from the singlet component mainly at the N/F 2 interface, where the amplitude of the singlet component is suppressed exponentially with increasing distance d F1 . The decay length of the empirical model is found to be comparable to twice the electron mean free path of F 1 and, thus, to the decay length of the singlet component in F 1 . Moreover, the obtained data is in qualitative agreement with the microscopic theory, which, however, predicts a (not investigated) breakdown of the triplet spin-valve effect for d F1 smaller than 0.3 to 0.4 times the magnetic coherence length, ξ F1 .
    Type of Medium: Online Resource
    ISSN: 2190-4286
    Language: English
    Publisher: Beilstein Institut
    Publication Date: 2016
    detail.hit.zdb_id: 2583584-1
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2017
    In:  Pervasive and Mobile Computing Vol. 35 ( 2017-02), p. 108-124
    In: Pervasive and Mobile Computing, Elsevier BV, Vol. 35 ( 2017-02), p. 108-124
    Type of Medium: Online Resource
    ISSN: 1574-1192
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2191455-2
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  • 3
    In: Antiviral Therapy, SAGE Publications, Vol. 16, No. 6 ( 2011-08), p. 815-824
    Abstract: According to guidelines, treatment of HCV infection should be considered a priority in HIV–HCV-coinfected patients. Methods This multicentre study includes HIV–HCV-coinfected patients diagnosed since 2001 in 14 participating centres in Austria and Germany. Demographic and virological data were recorded. Factors associated with non-initiation of HCV treatment were identified. Results Among 9,524 HIV patients screened, 1,033 HIV– HCV-coinfected patients were identified (male/female: 760/273; age: 43 ±9 years; weight: 71 ±12 kg; CD4 + T-cell nadir: 255 ±189 cells/μl; HCV RNA: 3.79x10 6 IU/ml; HIV RNA: 65x10 3 copies/ml). HCV genotype (GT) was predominantly GT-1 (62%). A total of 416 (40%) patients received HCV treatment, whereas 617 (60%) patients remained untreated. The main reasons for deferral of HCV treatment were patient refusal (20%), adherence/compliance (18%), active intravenous drug abuse (14%) and advanced immunodeficiency/AIDS (9%). Patients starting HCV treatment had significantly lower fibrosis stage (F2 versus F4; P 〈 0.0001), higher CD4 + T-cell count (530 cells/|il versus 430 cells/|il; P 〈 0.0001), lower HIV RNA levels (18x10 3 copies/ml versus 47x10 3 copies/ml; P=0.0008) and higher alanine aminotransferase (ALT; 113 IU/ml versus 75 IU/ml; P 〈 0.0001) than patients without initiation of HCV treatment. Age, HCV GTs, HCV RNA, haemoglobin levels, platelet count and white blood cell count were similar in patients receiving and in patients not receiving antiviral therapy. Multivariate analysis identified ALT levels ( P 〈 0.0001) and CD4 + T-cell count ( P 〈 0.0001) as independent predictors of treatment uptake. The overall sustained virological response (SVR) was 41% (155/416), with GT-1 and non-GT1 patients achieving SVR rates of 29% and 48%, respectively. Conclusions This large cohort study provides evidence for considerable under-treatment of chronic HCV infection in HIV patients. Despite acceptable treatment success in this real-life setting, HCV remains untreated in the majority of patients and often owing to potentially modifable reasons.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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