In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 38, No. 2-3 ( 2013), p. 196-204
Abstract:
〈 b 〉 〈 i 〉 Background/Aim: 〈 /i 〉 〈 /b 〉 The aim of the present study was to quantitatively examine factors associated with aortic calcification in non-dialysis CKD patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We quantitatively investigated aortic calcification from the renal artery to the bifurcation in 149 non-dialysis CKD patients (58±16 years; 96 males and 53 females, 48 diabetics; eGFR 40.3±29.3 ml/min), and measured Agatston scores using multi-slice computed tomography. 〈 b 〉 〈 i 〉 Result: 〈 /i 〉 〈 /b 〉 Of 149 patients, aortic calcification was present in 117. In patients with aortic calcification, age (p 〈 0.001), C-reactive protein (p 〈 0.001), and intact-PTH (p 〈 0.001) were significantly higher, estimated glomerular filtration rate (eGFR) was significantly lower (p 〈 0.001), and diabetes was observed more often (p 〈 0.05). In regards to the degree of aortic calcification, the Agatston scores correlated significantly and positively with age ( & #x03C1;=0.438, p 〈 0.001) and serum phosphate ( & #x03C1;=0.208, p=0.024), and correlated significantly but negatively with e-GFR ( & #x03C1;=-0.353, p 〈 0.001). In multiple regression analysis, eGFR was associated significantly and independently with the log [Agatston score] (β=-0.346, p 〈 0.01), after adjustment for several confounders including serum phosphate and the presence of diabetes. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Hyperphospatemia, chronic inflammation, diabetes, and decreased GFR are associated significantly with the presence of aortic calcification in non-dialysis CKD patients. Decreased eGFR was associated significantly and independently with the quantitative degree of aortic calcification.
Type of Medium:
Online Resource
ISSN:
1420-4096
,
1423-0143
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
1482922-8
Bookmarklink
