In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 49, No. 5 ( 2017-05), p. 1601505-
Abstract:
Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans. We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford–Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans. The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10 −12 ) at IKZF3 . Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as IKZF3 ( e.g. ZPBP2 , ORMDL3 and GSDMB ) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at GSDMB , but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1 , TSLP and GSDMB but not for IL33 . Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.
Type of Medium:
Online Resource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.01505-2016
DOI:
10.1183/13993003.01505-2016.Supp1
DOI:
10.1183/13993003.01505-2016.Supp2
Language:
English
Publisher:
European Respiratory Society (ERS)
Publication Date:
2017
detail.hit.zdb_id:
2834928-3
detail.hit.zdb_id:
1499101-9
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