KOBV Portal

Hits per page

hits 1 - 10 | 474 hits

Sorting

Online Resource

The Clinical Indications for Limited Surgery of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Kimura, Kenjiro ; Amano, Ryosuke ; Ymazoe, Sadaaki ; [et al.]

Springer Science and Business Media LLC ; 2017

In: World Journal of Surgery Vol. 41, No. 5 ( 2017-5), p. 1358-1365

add to watchlist on the watchlist

Details

In: World Journal of Surgery, Springer Science and Business Media LLC, Vol. 41, No. 5 ( 2017-5), p. 1358-1365

Type of Medium: Online Resource

ISSN: 0364-2313 , 1432-2323

URL: Article

DOI: 10.1007/s00268-016-3824-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 1463296-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Analysis of the origin of anaplastic pancreatic cancer and the mechanism of its dedifferentiation

Miura, Kotaro ; Kimura, Kenjiro ; Amano, Ryosuke ; [et al.]

Wiley ; 2017

In: Journal of Hepato-Biliary-Pancreatic Sciences Vol. 24, No. 3 ( 2017-03), p. 176-184

add to watchlist on the watchlist

Details

In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 24, No. 3 ( 2017-03), p. 176-184

Type of Medium: Online Resource

ISSN: 1868-6974

URL: Issue

URL: Article

DOI: 10.1002/jhbp.2017.24.issue-3

DOI: 10.1002/jhbp.429

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2536390-6

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

Tanaka, Ryota ; Eguchi, Shimpei ; Kimura, Kenjiro ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS ONE Vol. 18, No. 1 ( 2023-1-24), p. e0280348-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2023-1-24), p. e0280348-

Abstract: The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment (TME). Methods A total of 130 patients with BTC who underwent surgical treatment at our institution were enrolled in this study. We retrospectively evaluated TILs and TAMs with immunohistochemical staining. Results With CD8-high, CD4-high, FOXP3-high, and CD68-low in TME as one factor, we calculated Immunoscore according to the number of factors. The high Immunoscore group showed significantly superior overall survival (OS) and recurrence-free survival (RFS) than the low Immunoscore group (median OS, 60.8 vs. 26.4 months, p = 0.001; median RFS not reached vs. 17.2 months, p 〈 0.001). Also, high Immunoscore was an independent good prognostic factor for OS and RFS (hazards ratio 2.05 and 2.41 and p = 0.01 and p = 0.001, respectively). Conclusions High Immunoscore group had significantly superior OS and RFS and was an independent good prognostic factor for OS and RFS.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0280348

DOI: 10.1371/journal.pone.0280348.g001

DOI: 10.1371/journal.pone.0280348.g002

DOI: 10.1371/journal.pone.0280348.g003

DOI: 10.1371/journal.pone.0280348.g004

DOI: 10.1371/journal.pone.0280348.t001

DOI: 10.1371/journal.pone.0280348.t002

DOI: 10.1371/journal.pone.0280348.t003

DOI: 10.1371/journal.pone.0280348.t004

DOI: 10.1371/journal.pone.0280348.t005

DOI: 10.1371/journal.pone.0280348.t006

DOI: 10.1371/journal.pone.0280348.s001

DOI: 10.1371/journal.pone.0280348.s002

DOI: 10.1371/journal.pone.0280348.s003

DOI: 10.1371/journal.pone.0280348.s004

DOI: 10.1371/journal.pone.0280348.s005

DOI: 10.1371/journal.pone.0280348.s006

DOI: 10.1371/journal.pone.0280348.s007

DOI: 10.1371/journal.pone.0280348.r001

DOI: 10.1371/journal.pone.0280348.r002

DOI: 10.1371/journal.pone.0280348.r003

DOI: 10.1371/journal.pone.0280348.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Association of tumor infiltrating CD8 positive T cells and PDL-1 expression with survival after conversion surgery for unresectable gastric cancer.

Tanaka, Hiroaki ; Nishimura, Junya ; Miki, Yuichiro ; [et al.]

American Society of Clinical Oncology (ASCO) ; 2018

In: Journal of Clinical Oncology Vol. 36, No. 4_suppl ( 2018-02-01), p. 62-62

add to watchlist on the watchlist

Details

In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 36, No. 4_suppl ( 2018-02-01), p. 62-62

Abstract: 62 Background: Conversion surgery after chemotherapy responds to unresectable gastric cancer has long-term prognosis, however, chemotherapy after surgery should also be considered to improve treatment outcome. The effectiveness of immune checkpoint inhibitors for gastric cancer has been proved. In this study, we investigated the association between PDL-1 expression and CD8 + T cell infiltration in the primary tumor and prognosis of patients who underwent conversion surgery after S-1-based multidrug chemotherapy in unresectable gastric cancer. Methods: We evaluated PDL-1 expression and CD8 T cell infiltration by immunohistochemical staining and examined the relationship with prognosis in 90 patients with Stage IV gastric cancer who underwent gastrectomy in our department from 2007 to 2015. Results: 90 cases included 47 cases of palliative resection, 26 cases of CY1P 0cases and 17 cases of conversion surgery. Among Conversion Surgery cases, 11 (65%) patients underwent R0 surgery, and the 5-year survival rate was 66%. The 5-year survival rate of non-curative resected cases was 16%. In immunohistochemical examination, PDL-1 high expression was a poor prognostic factor in palliative surgery and CY1P0 cases. Meanwhile, in the case of Conversion Surgery, the 5-year survival rate was 58%, 32%, 61%, and 30% in the order of PDL-1 high expression group, low expression group, CD8 T cell high infiltration, and low infiltration group, respectively. Prognosis of PDL-1 high expression group and CD8 T cell infiltration group was good. There was no association between curative resection and neither of CD8 T cell infiltration or PDL-1 expression. Conclusions: We found that the prognosis was relatively good in patients where local immune response was enhanced, regardless of R0 excision. Our results suggested that infiltration of CD8 T cells in the primary tumor may be a prognostic predictor, and it is expected to use an immune check point inhibitor after conversion surgery for unresectable gastric cancer.

Type of Medium: Online Resource

ISSN: 0732-183X , 1527-7755

URL: Article

DOI: 10.1200/JCO.2018.36.4_suppl.62

RVK:

XA 52760

RVK:

XA 10000

Language: English

Publisher: American Society of Clinical Oncology (ASCO)

Publication Date: 2018

detail.hit.zdb_id: 2005181-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Validation of the 2015 AGA Guideline for asymptomatic neoplastic pancreatic cysts focused on completion of follow up after 5-year surveillance

Kimura, Kenjiro ; Amano, Ryosuke ; Yamazoe, Sadaaki ; [et al.]

Elsevier BV ; 2016

In: Pancreatology Vol. 16, No. 4 ( 2016-08), p. S73-

add to watchlist on the watchlist

Details

In: Pancreatology, Elsevier BV, Vol. 16, No. 4 ( 2016-08), p. S73-

Type of Medium: Online Resource

ISSN: 1424-3903

URL: Article

DOI: 10.1016/j.pan.2016.06.263

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2043694-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Abstract 2945: Impact of intratumoral mature dendritic cells on prognosis of the patients with esophageal squamous cell carcinoma

Nishimura, Junya ; Tanaka, Hiroaki ; Miki, Yuichiro ; [et al.]

American Association for Cancer Research (AACR) ; 2017

In: Cancer Research Vol. 77, No. 13_Supplement ( 2017-07-01), p. 2945-2945

add to watchlist on the watchlist

Details

In: Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 2945-2945

Abstract: [Background] Promising efficacy of the immunotherapy with anti-PD-1 antibody for esophageal squamous cell carcinoma (ESCC) is expected. Tumor-infiltrating lymphocytes (TILs)have been found to be associated with favorable outcome of patients in many cancers including ESCC. However, the contributing factor of TILs in the primary tumor remains unclear. Dendritic cells (DCs) are the most potent antigen-presenting cells to induce cytotoxic T lymphocytes. [Purpose] The aim of this study was to examine the correlation of mature dendritic cells with CD8+ cells in the tumor in order to clarify the impact of DCs on locally infiltrated lymphocytes in ESCC. [Object and Methods] Formalin-fixed, paraffin-embedded blocks of primary lesions were collected from 80 patients with ESCC who underwent surgical treatment at Osaka City University Hospital. Immunohistochemical analysis using anti-LAMP-3 antibody and CD8 antibody was used to evaluate intratumoral DCs and TILs. The number of LAMP-3+DCs and TILs were counted at ×400 magnification. We divided the 80 cases into two groups according to the median number of intratumoral DCs and TILs to examine the clinicopathological features. [Results] LAMP-3+DCs were predominantly observed in peritumoral area and sparsely found in intratumoral area, whereas CD8+T cells distributed between both peritumoral and intratumoral areas. The number of DCs was significantly associated with increasing TNM stage. For example, the median number of DCs was 59.9 in pathological T1, 34.2 in T2/3, 62.4 in pN1, 34.1 in pN1/2/3. In addition, many patients with high infiltaraion of DCs had positive lymphatic invasion (Ly). The number of intratumoral DCs was significantly correlated with the number of TILs which were observed in intratumoral regions. Patients in the high infiltration of DCs group showed a significant better prognosis than patients in the low infiltration group. Double staining showed that LAMP3+DC-CD8+T cell clusters were seen in peritumoral area. Citation Format: Junya Nishimura, Hiroaki Tanaka, Yuichiro Miki, Tatsuro Tamura, Tatsunari Fukuoka, Go Ohira, Masatsune Shibutani, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Hisashi Nagahara, Ryosuke Amano, Kazuya Muguruma, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira. Impact of intratumoral mature dendritic cells on prognosis of the patients with esophageal squamous cell carcinoma [abstract]. In: Proceedings of the American Associati on for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2945. doi:10.1158/1538-7445.AM2017-2945

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/1538-7445.AM2017-2945

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2017

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Abstract 1468: Intratumoral tertiary lymphoid structures are associated with favorable prognosis of patients with gastric cancer

Sakimura, Chie ; Tanaka, Hiroaki ; Tamura, Tatsuro ; [et al.]

American Association for Cancer Research (AACR) ; 2016

In: Cancer Research Vol. 76, No. 14_Supplement ( 2016-07-15), p. 1468-1468

add to watchlist on the watchlist

Details

In: Cancer Research, American Association for Cancer Research (AACR), Vol. 76, No. 14_Supplement ( 2016-07-15), p. 1468-1468

Abstract: Background: The host immune system is one of the key players of anti-tumor functions. High numbers of tumor infiltrating lymphocytes has been showed to be a predictor of favorable clinical outcome in several solid cancers. The role of B cells in tumor microenvironment is still unclear. Recent studies have reported a correlation between the densities of B cells and the favorable clinical outcome of cancer patients. Moreover, some studies considered the organization of tumor infiltrating B cells as criteria in addition to the cell density. Tertiary lymphoid structures (TLSs) are defined as transient ectopic lymphoid organizations that can develop in non-lymphoid tissues at the site of chronic inflammation, and are anatomically and functionally similar to secondary lymphoid organs. In the present study, we investigated the association between tumor infiltrating B cells and clinicopathological features in gastric cancer. Materials and Methods: Tumor blocks were obtained from 226 patients with stage Ib to stage IV gastric cancer who had undergone initial surgical resection. The density of CD20+ B cells within the tumor and invasive margin area was assessed by immunohistochemistry. We also evaluated CD3+ T cells, CD21+ follicular dendritic cells (FDCs), Bcl6 germinal center B cells, and PNAd+ high endothelial venules (HEVs) to show the presence of TLSs in gastric cancer. Results: Tumor infiltrating B cells mostly organized clusters surrounded by CD3+ T cells. B cell area contained FDCs and some clusters had Bcl6+ B cells. There were HEVs around follicles. We observed most of TLSs at the tumor invasive margin. Kaplan-Meier survival analysis showed that high number of CD20+ B cells was associated with significantly better survival (P & lt;0.0001). Univariate analysis demonstrated a correlation between CD20 high and longer OS, and multivariate analysis also showed that CD20 high was one of the independent predictors of OS. Conclusion: We demonstrated that B cells mostly infiltrated as TLSs and were associated with better prognosis in patients with gastric cancer. Our results suggested that B cells, perhaps as the structure of TLSs, might play an important role for immune response against gastric cancer. Citation Format: Chie Sakimura, Hiroaki Tanaka, Tatsuro Tamura, Go Ohira, Masatsune Shibutani, Sadaaki Yamazoe, Katsunobu Sakurai, Hisashi Nagahara, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa. Intratumoral tertiary lymphoid structures are associated with favorable prognosis of patients with gastric cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1468.

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/1538-7445.AM2016-1468

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2016

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Giant duodenal ulcers after neurosurgery for brainstem tumors that required reoperation for gastric disconnection: a report of two cases

Nobori, Chihoko ; Kimura, Kenjiro ; Ohira, Go ; [et al.]

Springer Science and Business Media LLC ; 2016

In: BMC Surgery Vol. 16, No. 1 ( 2016-12)

add to watchlist on the watchlist

Details

In: BMC Surgery, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2016-12)

Type of Medium: Online Resource

ISSN: 1471-2482

URL: Article

DOI: 10.1186/s12893-016-0189-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2050442-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A case of perforation of a pancreatic duct by a pancreatic stent during chemoradiotherapy for pancreatic head cancer: a case report

Mori, Takuya ; Ohira, Go ; Kimura, Kenjiro ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Surgical Case Reports Vol. 5, No. 1 ( 2019-12)

add to watchlist on the watchlist

Details

In: Surgical Case Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2019-12)

Type of Medium: Online Resource

ISSN: 2198-7793

URL: Article

DOI: 10.1186/s40792-019-0571-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2809613-7

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Efficacy of Transhepatic Anterior Approach to the Inferior Vena Cava for Malignant Pheochromocytoma Invading Right Posterior Lobe of the Liver: A Case Report

Tsujio, Gen ; Kimura, Kenjiro ; Tauchi, Yukie ; [et al.]

International College of Surgeons ; 2018

In: International Surgery Vol. 103, No. 1-2 ( 2018-04-01), p. 80-86

add to watchlist on the watchlist

Details

In: International Surgery, International College of Surgeons, Vol. 103, No. 1-2 ( 2018-04-01), p. 80-86

Abstract: The anterior approach to the inferior vena cava (IVC) by the liver hanging maneuver is effective in resecting large retrohepatic tumors without mobilizing the right lobe. Case presentation: A 50-year-old man was referred to our hospital with a diagnosis of pheochromocytoma. He had severe congestive heart failure and cardiac ejection fraction was 15%. Abdominal magnetic resonance imaging (MRI) and ultrasonography (US) showed an adrenal mass about 80 mm in diameter. The tumor-infiltrated posterior segment of the right hepatic lobe and tumor were widely attached to the IVC. After treatment of congestive heart failure with conservative therapy, surgery was planned. Right adrenectomy and right hepatectomy were performed, the latter using the liver hanging maneuver to avoid mobilizing the right lobe, and we were able to minimize blood pressure fluctuations and perform the operation safely. The histopathologic diagnosis was malignant pheochromocytoma. Conclusions: We performed right hepatectomy without mobilizing the right lobe by the liver hanging maneuver and minimized stimulation of the tumor. We could perform the operation safely using the liver hanging maneuver, which seems effective in such cases.

Type of Medium: Online Resource

ISSN: 0020-8868 , 2520-2456

URL: Article

DOI: 10.9738/INTSURG-D-17-00130.1

Language: English

Publisher: International College of Surgeons

Publication Date: 2018

detail.hit.zdb_id: 2151533-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 474 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg