In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-12), p. e0262267-
Abstract:
The features of hepatitis C virus patients with a sustained virologic response (SVR) who developed hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) therapy are unclear. Methods The study population included 1494 DAA-SVR patients without a history of HCC. The cumulative carcinogenesis rate after the end of treatment (EOT) and factors related to HCC were analyzed. Results Sixty (4.0%) patients developed HCC during a median observation period of 47.6 months. At four years, the cumulative carcinogenesis rate was 4.7%. A Cox proportional hazards analysis showed that age ≥73 years (hazard ratio [HR]: 2.148), male sex (HR: 3.060), hyaluronic acid (HA) ≥75 ng/mL (HR: 3.996), alpha-fetoprotein at EOT (EOT-AFP) ≥5.3 ng/mL (HR: 4.773), and albumin at EOT (EOT-Alb) 〈 3.9 g/dL (HR: 2.305) were associated with HCC development. Especially, EOT-AFP ≥5.3 ng/mL was associated with HCC development after 3 years from EOT (HR: 6.237). Among patients who developed HCC, AFP did not increase in patients with EOT-AFP 〈 5.3 ng/mL at the onset of HCC. Of these 5 factors, EOT-AFP ≥5.3 ng/mL was scored as 2 points; the others were scored as 1 point. The 4-year cumulative carcinogenesis rate for patients with total scores of 0–2, 3–4, and 5–6 points were 0.6%, 11.9%, and 27.1%, respectively (p 〈 0.001). Conclusions EOT-AFP ≥5.3 ng/mL is useful for predicting HCC development after an SVR. However, AFP does not increase in patients with EOT-AFP 〈 5.3 ng/mL at the onset of HCC. The combination of EOT-AFP, age, sex, HA, and EOT-Alb is important for predicting carcinogenesis.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0262267
DOI:
10.1371/journal.pone.0262267.g001
DOI:
10.1371/journal.pone.0262267.g002
DOI:
10.1371/journal.pone.0262267.g003
DOI:
10.1371/journal.pone.0262267.g004
DOI:
10.1371/journal.pone.0262267.g005
DOI:
10.1371/journal.pone.0262267.g006
DOI:
10.1371/journal.pone.0262267.g007
DOI:
10.1371/journal.pone.0262267.g008
DOI:
10.1371/journal.pone.0262267.g009
DOI:
10.1371/journal.pone.0262267.t001
DOI:
10.1371/journal.pone.0262267.t002
DOI:
10.1371/journal.pone.0262267.t003
DOI:
10.1371/journal.pone.0262267.t004
DOI:
10.1371/journal.pone.0262267.t005
DOI:
10.1371/journal.pone.0262267.t006
DOI:
10.1371/journal.pone.0262267.s001
DOI:
10.1371/journal.pone.0262267.s002
DOI:
10.1371/journal.pone.0262267.r001
DOI:
10.1371/journal.pone.0262267.r002
DOI:
10.1371/journal.pone.0262267.r003
DOI:
10.1371/journal.pone.0262267.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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