In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 161, No. Suppl. 2 ( 2013), p. 147-153
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Total and specific immunoglobulin E (IgE) in nasal polyps (NP) is related to local eosinophilic inflammation. However, it remains unclear which antigens cause a stronger accumulation of eosinophils in NP. We investigated whether local IgEs to specific antigens correlated with local eosinophil accumulation. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Total IgE, antigen-specific IgEs [5 species of fungi 〈 i 〉 , 〈 /i 〉 staphylococcal enterotoxins A and B (SEA and SEB), cedar pollen, ragweed pollen and house-dust mites] and eosinophil cationic protein (ECP) were measured in sinus mucosa homogenates and serum from 29 patients with chronic rhinosinusitis with NP (CRSwNP), 8 patients with allergic fungal rhinosinusitis (AFRS) and 8 control subjects without CRS. The level of ECP in NP was analyzed for correlations with the total and specific IgE levels in the serum and NP. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In CRSwNP, antigen-specific IgEs [ 〈 i 〉 Alternaria 〉 〈 /i 〉 mite 〈 i 〉 (Dp) 〉 Aspergillus 〉 〈 /i 〉 SEB 〈 i 〉 〉 Penicillium 〉 〈 /i 〉 mite 〈 i 〉 (Df) 〈 /i 〉 , but not the other fungi, SEA or pollens] in the sinus mucosa correlated significantly with the local ECP. 〈 b 〉 〈 /b 〉 In AFRS, antigen-specific IgEs [ 〈 i 〉 Penicillium 〉 〈 /i 〉 mite 〈 i 〉 (Df) 〉 Alternaria, 〈 /i 〉 but not the other fungi, SEs or pollens] in the sinus mucosa correlated significantly with the local ECP. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Local total IgE and antigen (fungi, mites and SEs)-specific IgEs in NP are related to the local eosinophilic inflammation of AFRS and CRSwNP.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
1482722-0
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