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  • 1
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 10 ( 2022-10-29), p. 225-228
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 10 ( 2022-10-29), p. 225-228
    Abstract: Chronic kidney disease (CKD) in high-risk pregnancies is a challenge for multidisciplinary teams of doctors. Due to the fact that the disease affects both the mother and the fetus, and the course of the pregnancy. The following article reviews the literature about the interaction between pregnancy and CKD and dialysis therapy. Even pregnancy itself can lead to a worsening of kidney dysfunction. The risk of this consequence increases with the degree of renal failure, therefore renal parameters and other pregnancy test results should be monitored. On the other hand, the most common complications of chronic kidney disease in pregnancy described in the literature include pre-eclampsia, preterm labor, intrauterine growth restriction (IUGR) or low birth weight, surgical delivery by caesarean section and miscarriage. Dialysis therapy also leads to abnormalities in the course of pregnancy, and patients require constant monitoring during its course. Attention is also drawn to the high percentage of newborns requiring intensive postpartum care. Due to the risk for the fetus and mother mentioned in the article, nephrologists and gynecologists should cooperate closely from the pre-contraceptive period in order to reduce the risk of sequelae and better control of the underlying disease.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 2
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 13, No. 1 ( 2022-11-24), p. 85-89
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 13, No. 1 ( 2022-11-24), p. 85-89
    Abstract: SARS-CoV-2 infection leads to severe multiple organ failure. The immune system is stimulated by activating the inflammatory mechanism and by releasing inflammatory cytokines. COVID-19 is able to penetrate the central nervous system, inducing neuritis and neurodegeneration. In our study, we analyzed the latest available articles. We focused on the subject of COVID-19 infection and consequences of neuroinflammation. For this study, we searched the literature available in Pubmed and Google Scholar databases using keywords. There is evidence of a common background of COVID-19 complications and neurological diseases such as Parkinson's or Alzheimer's disease. This type of complication is more frequently observed in serious cases of COVID-19, with a more intense immune response, with higher levels of CRP, ferritin and D-dimers. Organic changes in conjunction with environmental stress caused by the experience of severe illness, fear of becoming ill and social limitations, lead to neuropsychiatric pathologies, including major depressive disorders and post-traumatic stress. The neuropsychiatric implications of COVID-19 represent a severe clinical problem that deserves special attention in the treatment of COVID-19 infection. There is a need to monitor the neuropsychiatric consequences of COVID-19, in order to completely understand the impact of SARS-CoV-2 infection. This knowledge is necessary to be able to confront the public health crisis created by the COVID-19 pandemic. 
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 3
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 10 ( 2022-10-05), p. 107-112
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 10 ( 2022-10-05), p. 107-112
    Abstract: Arystolocholic acid nephropathy is chronic kidney disease caused by the use of substances of natural origin that contain arystolocholic acid. The effects of their use are arystolochic acid nephropathies, which include "Chinese Herbs" nephropathy. The course of the disease is very fast, resulting in progression to end-stage renal disease, and in the future it results in the development of urinary tract cancer. That is why it is so important to recognize it early and start treatment. However, due to disease progression, some patients require dialysis and even kidney transplantation. Although the World Health Organization is trying to stop the spread of the use of harmful substances, there are still reports of this nephropathy appearing in some populations. Despite warnings from the Food and Drug Administration regarding the safety of botanicals containing arystolochic acid and its classification as a human carcinogen, products containing it are still available for purchase online. The purpose of the literature review below is to analyze the latest knowledge on aristolochic acid nephropathy and its associated complication.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 4
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 12 ( 2022-11-16), p. 123-130
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 12 ( 2022-11-16), p. 123-130
    Abstract: Home hemodialysis (HHD) is a discovery from 1961 that is now experiencing a revival. It is a convenient and modern method of renal replacement therapy that allows the patient to undergo hemodialysis sessions at home. Due to the growing interest in home hemodialysis, we decided to present the potential of this renal replacement method, show both its benefits and complications resulting from its use. Undoubtedly, HHD has many benefits resulting mainly from the possibility of regulating the duration of the sessions and increasing their frequency. However, this method is also burdened with numerous complications. There are training courses in the use of HHD for patients who have just been diagnosed with end-stage renal disease as well as for patients undergoing dialysis using other methods. Appropriate patient selection is an important factor for the success of home therapy. There is a fierce battle in the home hemodialysis machine market. Manufacturers are outdoing each other in innovative technologies to ensure ease of use, trouble-free operation and minimize complications. The costs of home hemodialysis include more components than the dialysis treatment itself. Home hemodialysis gives patients comfort and independence above all. This is part of nephrology that undoubtedly requires a lot of work and development, but is certainly an invention of the 21st century.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 5
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 8 ( 2022-08-25), p. 1111-1123
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 8 ( 2022-08-25), p. 1111-1123
    Abstract: Introduction and purpose Due to the growing tendency to diagnose obesity in patients, scientists are trying to find drugs that facilitate weight reduction.  An example of such a formulation is the GLP-1 analogue semaglutide. The following article is an analysis of the current knowledge on the effectiveness and safety of obesity treatment with semaglutide based on available publications in Pubmed and Google Scholar databases. State of knowledge The main mechanism of semaglutide is based on a stimulation of insulin secretion from pancreatic beta cells, and inhibition of glucagon from alpha cells, inhibition of hepatic gluconeogenesis, and reduction of energy consumption with minimal impact on energy expenditure. In clinical trials, it showed the best results compared to placebo and other drugs used in weight reduction. Participants treated with semaglutide achieved a reduction in waist circumference, improvements in blood pressure parameters, HbA1c levels, total cholesterol, LDL cholesterol, triglycerides, and CRP protein, and increased HDL cholesterol levels. Semaglutide is well tolerated by patients, and its main side effects come from the gastrointestinal tract, including nausea, emesis, diarrhea. Summary The analysis of the latest publications and meta-analyzes of the literature shows that the use of semaglutide is safe and effective in the treatment of obesity. The positive effect of semaglutide on weight reduction also contributes to the reduction of the risk of cardiovascular events and other obesity-related complications. It is also well tolerated by patients, which translates into possible longer use, and weekly subcutaneous injections are not burdensome for patients. Key words: semaglutide; obesity; GLP-1 analogue; overweight
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 6
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 12 ( 2022-11-17), p. 141-145
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 12 ( 2022-11-17), p. 141-145
    Abstract: Coronavirus disease-2019 (COVID-19) is a global pandemic health problem that causes a wide spectrum of clinical manifestations. Recovered patients who survive COVID-19 may continue to report a wide variety of clinical manifestations such as depression, which is named post covid syndrome. In our article, we sought to determine the frequency and possible causes of depressive symptoms and clinically-significant depression in the post COVID syndrome. We conducted a review of postcovid manifestations by searching PubMed, Scopus, World health organization (WHO) databases. The symptoms of postcovid syndrome have been shown as a weakness, cognitive impairment, sleep disturbance, and depression, among others. Persistent mental disorders among people who suffer from long-term COVID-19 may be related to psychological factors, as well as from infection and the associated neurobiological trauma. According to available studies, a significant percentage of depression symptoms is observed among people with postcovid syndrome, especially in older age groups. Also symptoms of mental, neurological and physical illness as well as inflammatory brain injury in people with post-COVID syndrome are likely to increase suicidal ideation and behavior in this patient population.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 7
    Online Resource
    Online Resource
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2022
    In:  Journal of Education, Health and Sport Vol. 12, No. 8 ( 2022-08-25), p. 1143-1155
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 12, No. 8 ( 2022-08-25), p. 1143-1155
    Abstract: Introduction and purposeThe COVID-19 pandemic, which has been ongoing since early 2020, has significantly affected the health care system worldwide. SARS-CoV-2 virus being the etiological factor of the disease has a high affinity for the renal organ. The purpose of this study was to provide an overview of the current knowledge of the problem of frequent AKI in the course of coronavirus infection, the impact of COVID-19 disease in patients with chronic kidney disease and on renal replacement therapy or dialysis.Review methodIn the process of writing, we used available articles and scientific papers in Pubmed and Google Scholar databases based on keywords: COVID-19, SARS-CoV-2, AcuteKidneyInjury, ChronicKidneyDisease.State of knowledgeSARS-CoV-2 virus enters target cells through the ACE2 receptor. In the pathophysiology of AKI in the course of COVID-19, a key role is attributed to secondary damage mechanisms such as cytokine storm, hypoperfusion with hypoxia, endothelial dysfunction. The incidence of acute kidney injury ranges from 5.1% to 36.6%. The development of AKI, renal transplant status, the presence of chronic kidney disease or renal replacement therapy is associated with an increased risk of severe course and higher mortality on COVID-19. SummaryThe COVID-19 pandemic has posed new logistical and therapeutic challenges to the health care system. Due to the high tropism of SARS-CoV-2 to the kidneys and the frequent occurrence of AKI during the course of the infection, nephrology patients, those on renal replacement therapy and those awaiting transplantation should be placed under special surveillance. Patients in these groups are at particular risk for a severe course of COVID-19.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2022
    detail.hit.zdb_id: 2842726-9
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  • 8
    In: Journal of Hazardous Materials, Elsevier BV, Vol. 440 ( 2022-10), p. 129795-
    Type of Medium: Online Resource
    ISSN: 0304-3894
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1491302-1
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  • 9
    In: Chemical Engineering Journal, Elsevier BV, Vol. 481 ( 2024-02), p. 148329-
    Type of Medium: Online Resource
    ISSN: 1385-8947
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 241367-X
    detail.hit.zdb_id: 2012137-4
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  • 10
    In: Cells, MDPI AG, Vol. 10, No. 10 ( 2021-10-16), p. 2774-
    Abstract: The process of anther culture involves numerous abiotic stresses required for cellular reprogramming, microspore developmental switch, and plant regeneration. These stresses affect DNA methylation patterns, sequence variation, and the number of green plants regenerated. Recently, in barley (Hordeum vulgare L.), mediation analysis linked DNA methylation changes, copper (Cu2+) and silver (Ag+) ion concentrations, sequence variation, β-glucans, green plants, and duration of anther culture (Time). Although several models were used to explain particular aspects of the relationships between these factors, a generalized complex model employing all these types of data was not established. In this study, we combined the previously described partial models into a single complex model using the structural equation modeling approach. Based on the evaluated model, we demonstrated that stress conditions (such as starvation and darkness) influence β-glucans employed by cells for glycolysis and the tricarboxylic acid cycle. Additionally, Cu2+ and Ag+ ions affect DNA methylation and induce sequence variation. Moreover, these ions link DNA methylation with green plants. The structural equation model also showed the role of time in relationships between parameters included in the model and influencing plant regeneration via anther culture. Utilization of structural equation modeling may have both scientific and practical implications, as it demonstrates links between biological phenomena (e.g., culture-induced variation, green plant regeneration and biochemical pathways), and provides opportunities for regulating these phenomena for particular biotechnological purposes.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2661518-6
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