KOBV Portal

Hits per page

hits 1 - 10 | 68 hits

Sorting

Online Resource

Between-meal sucrose-sweetened beverage consumption impairs glycaemia and lipid metabolism during prolonged sitting: A randomized controlled trial

Varsamis, Pia ; Formosa, Melissa F. ; Larsen, Robyn N. ; [et al.]

Elsevier BV ; 2019

In: Clinical Nutrition Vol. 38, No. 4 ( 2019-08), p. 1536-1543

add to watchlist on the watchlist

Details

In: Clinical Nutrition, Elsevier BV, Vol. 38, No. 4 ( 2019-08), p. 1536-1543

Type of Medium: Online Resource

ISSN: 0261-5614

URL: Article

DOI: 10.1016/j.clnu.2018.08.021

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2009052-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Online Resource

Optimizing metaproteomics database construction: lessons from a study of the vaginal microbiome

Lee, Elliot M. ; Srinivasan, Sujatha ; Purvine, Samuel O. ; [et al.]

American Society for Microbiology ; 2023

In: mSystems

add to watchlist on the watchlist

Details

In: mSystems, American Society for Microbiology

Abstract: Metaproteomic analysis can provide valuable insights into the functions of microbial and cellular communities by identifying a broad, untargeted set of proteins. The databases used in the analysis of metaproteomic data influence results by defining what proteins can be identified. Moreover, the size of the database impacts the number of identifications after accounting for false discovery rates (FDRs). Few studies have tested the performance of different strategies for building a protein database to identify proteins from metaproteomic data and those that have largely focused on highly diverse microbial communities. We tested a range of databases on CVL samples and found that a hybrid sample-matched approach, using publicly available proteins from organisms present in the samples, as well as proteins translated from metagenomic sequencing of the samples, had the best performance. However, our results also suggest that public sequence databases will continue to improve as more bacterial genomes are published.

Type of Medium: Online Resource

ISSN: 2379-5077

URL: Article

DOI: 10.1128/msystems.00678-22

Language: English

Publisher: American Society for Microbiology

Publication Date: 2023

detail.hit.zdb_id: 2844333-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Differences in visitor characteristics and experiences on episodic free admission days

Bowman, Catherine D. D. ; Adkins, Adrianna ; Owen, Brooke L. ; [et al.]

Informa UK Limited ; 2020

In: Museum Management and Curatorship Vol. 35, No. 3 ( 2020-05-03), p. 264-280

add to watchlist on the watchlist

Details

In: Museum Management and Curatorship, Informa UK Limited, Vol. 35, No. 3 ( 2020-05-03), p. 264-280

Type of Medium: Online Resource

ISSN: 0964-7775 , 1872-9185

URL: Article

DOI: 10.1080/09647775.2019.1578992

RVK:

AK 80100

Language: English

Publisher: Informa UK Limited

Publication Date: 2020

detail.hit.zdb_id: 1500653-0

SSG: 9,10

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Online Resource

Protein abundances can distinguish between naturally-occurring and laboratory strains of Yersinia pestis, the causative agent of plague

Merkley, Eric D. ; Sego, Landon H. ; Lin, Andy ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS ONE Vol. 12, No. 8 ( 2017-8-30), p. e0183478-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 12, No. 8 ( 2017-8-30), p. e0183478-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0183478

DOI: 10.1371/journal.pone.0183478.g001

DOI: 10.1371/journal.pone.0183478.g002

DOI: 10.1371/journal.pone.0183478.g003

DOI: 10.1371/journal.pone.0183478.t001

DOI: 10.1371/journal.pone.0183478.t002

DOI: 10.1371/journal.pone.0183478.t003

DOI: 10.1371/journal.pone.0183478.s001

DOI: 10.1371/journal.pone.0183478.s002

DOI: 10.1371/journal.pone.0183478.s003

DOI: 10.1371/journal.pone.0183478.s004

DOI: 10.1371/journal.pone.0183478.s005

DOI: 10.1371/journal.pone.0183478.s006

DOI: 10.1371/journal.pone.0183478.s007

DOI: 10.1371/journal.pone.0183478.s008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Investigation of Yersinia pestis Laboratory Adaptation through a Combined Genomics and Proteomics Approach

Leiser, Owen P. ; Merkley, Eric D. ; Clowers, Brian H. ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 11 ( 2015-11-24), p. e0142997-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 11 ( 2015-11-24), p. e0142997-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0142997

DOI: 10.1371/journal.pone.0142997.g001

DOI: 10.1371/journal.pone.0142997.g002

DOI: 10.1371/journal.pone.0142997.t001

DOI: 10.1371/journal.pone.0142997.t002

DOI: 10.1371/journal.pone.0142997.t003

DOI: 10.1371/journal.pone.0142997.t004

DOI: 10.1371/journal.pone.0142997.s001

DOI: 10.1371/journal.pone.0142997.s002

DOI: 10.1371/journal.pone.0142997.s003

DOI: 10.1371/journal.pone.0142997.s004

DOI: 10.1371/journal.pone.0142997.s005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

Saxer, Gerda ; Krepps, Michael D. ; Merkley, Eric D. ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS Genetics Vol. 10, No. 12 ( 2014-12-11), p. e1004872-

add to watchlist on the watchlist

Details

In: PLoS Genetics, Public Library of Science (PLoS), Vol. 10, No. 12 ( 2014-12-11), p. e1004872-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1004872

DOI: 10.1371/journal.pgen.1004872.g001

DOI: 10.1371/journal.pgen.1004872.g002

DOI: 10.1371/journal.pgen.1004872.g003

DOI: 10.1371/journal.pgen.1004872.g004

DOI: 10.1371/journal.pgen.1004872.g005

DOI: 10.1371/journal.pgen.1004872.g006

DOI: 10.1371/journal.pgen.1004872.g007

DOI: 10.1371/journal.pgen.1004872.g008

DOI: 10.1371/journal.pgen.1004872.g009

DOI: 10.1371/journal.pgen.1004872.t001

DOI: 10.1371/journal.pgen.1004872.s001

DOI: 10.1371/journal.pgen.1004872.s002

DOI: 10.1371/journal.pgen.1004872.s003

DOI: 10.1371/journal.pgen.1004872.s004

DOI: 10.1371/journal.pgen.1004872.s005

DOI: 10.1371/journal.pgen.1004872.s006

DOI: 10.1371/journal.pgen.1004872.s007

DOI: 10.1371/journal.pgen.1004872.s008

DOI: 10.1371/journal.pgen.1004872.s009

DOI: 10.1371/journal.pgen.1004872.s010

DOI: 10.1371/journal.pgen.1004872.s011

DOI: 10.1371/journal.pgen.1004872.s012

DOI: 10.1371/journal.pgen.1004872.s013

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2186725-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Ask Dr. Discovery: the impact of a casual mobile game on visitor engagement with science museum content

Nelson, Brian C. ; Bowman, Catherine D. D. ; Bowman, Judd D. ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Educational Technology Research and Development Vol. 68, No. 1 ( 2020-2), p. 345-362

add to watchlist on the watchlist

Details

In: Educational Technology Research and Development, Springer Science and Business Media LLC, Vol. 68, No. 1 ( 2020-2), p. 345-362

Type of Medium: Online Resource

ISSN: 1042-1629 , 1556-6501

URL: Article

DOI: 10.1007/s11423-019-09696-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2164476-7

SSG: 5,3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative ; Niemi, Mari E. K. ; Karjalainen, Juha ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Vol. 600, No. 7889 ( 2021-12-16), p. 472-477

add to watchlist on the watchlist

Details

In: Nature, Springer Science and Business Media LLC, Vol. 600, No. 7889 ( 2021-12-16), p. 472-477

Abstract: The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases 3–7 . They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-021-03767-x

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

Online Resource

A second update on mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative ; Kanai, Masahiro ; Andrews, Shea J. ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Vol. 621, No. 7977 ( 2023-09-07), p. E7-E26

add to watchlist on the watchlist

Details

In: Nature, Springer Science and Business Media LLC, Vol. 621, No. 7977 ( 2023-09-07), p. E7-E26

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-023-06355-3

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

Online Resource

Whole-genome sequencing reveals host factors underlying critical COVID-19

Kousathanas, Athanasios ; Pairo-Castineira, Erola ; Rawlik, Konrad ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Vol. 607, No. 7917 ( 2022-07-07), p. 97-103

add to watchlist on the watchlist

Details

In: Nature, Springer Science and Business Media LLC, Vol. 607, No. 7917 ( 2022-07-07), p. 97-103

Abstract: Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling ( IL10RB and PLSCR1 ), leucocyte differentiation ( BCL11A ) and blood-type antigen secretor status ( FUT2 ). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase ( ATP11A ), and increased expression of a mucin ( MUC1 )—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules ( SELE , ICAM5 and CD209 ) and the coagulation factor F8 , all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-022-04576-6

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

hits 1 - 10 | 68 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg