In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 102, No. 8 ( 2009-10-28), p. 1195-1202
Abstract:
Few studies have investigated the absorption of phylloquinone (vitamin K 1 ). We recruited twelve healthy, non-obese adults. On each study day, fasted subjects took a capsule containing 20 μg of 13 C-labelled phylloquinone with one of three meals, defined as convenience, cosmopolitan and animal-oriented, in a three-way crossover design. The meals were formulated from the characteristics of clusters identified in dietary pattern analysis of data from the National Diet and Nutrition Survey conducted in 2000–1. Plasma phylloquinone concentration and isotopic enrichment were measured over 8 h. Significantly more phylloquinone tracer was absorbed when consumed with the cosmopolitan and animal-oriented meals than with the convenience meal ( P = 0·001 and 0·035, respectively). Estimates of the relative availability of phylloquinone from the meals were: convenience meal = 1·00; cosmopolitan meal = 0·31; animal-oriented meal = 0·23. Combining the tracer data with availability estimates for phylloquinone from the meals provides overall relative bioavailability values of convenience = 1·00, cosmopolitan = 0·46 and animal-oriented = 0·29. Stable isotopes provide a useful tool to investigate further the bioavailability of low doses of phylloquinone. Different meals can affect the absorption of free phylloquinone. The meal-based study design used in the present work provides an approach that reflects more closely the way foods are eaten in a free-living population.
Type of Medium:
Online Resource
ISSN:
0007-1145
,
1475-2662
DOI:
10.1017/S0007114509371688
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2009
detail.hit.zdb_id:
2016047-1
SSG:
12
SSG:
21
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