In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 10 ( 2023-10-3), p. e0292180-
Abstract:
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, fostering collaborative research, and establishing a clinical trial-ready cohort is imperative. Based on a systematic review of the English literature on monogenic PD and a successful team science approach, we have built up a network of 59 sites worldwide and have collected information on the availability of data, biomaterials, and facilities. To enable access to this resource and to foster collaboration across centers, as well as between academia and industry, we have developed an interactive map and online tool allowing for a quick overview of available resources, along with an option to filter for specific items of interest. This initiative is currently being merged with the Global Parkinson’s Genetics Program (GP2), which will attract additional centers with a focus on underrepresented sites. This growing resource and tool will facilitate collaborative research and impact the development and testing of new therapies for monogenic and potentially for idiopathic PD patients.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0292180
DOI:
10.1371/journal.pone.0292180.g001
DOI:
10.1371/journal.pone.0292180.g002
DOI:
10.1371/journal.pone.0292180.g003
DOI:
10.1371/journal.pone.0292180.t001
DOI:
10.1371/journal.pone.0292180.s001
DOI:
10.1371/journal.pone.0292180.s002
DOI:
10.1371/journal.pone.0292180.s003
DOI:
10.1371/journal.pone.0292180.r001
DOI:
10.1371/journal.pone.0292180.r002
DOI:
10.1371/journal.pone.0292180.r003
DOI:
10.1371/journal.pone.0292180.r004
DOI:
10.1371/journal.pone.0292180.r005
DOI:
10.1371/journal.pone.0292180.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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