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Genome-wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Tsetsos, Fotis ; Topaloudi, Apostolia ; Jain, Pritesh ; [et al.]

Elsevier BV ; 2023

In: Biological Psychiatry ( 2023-2)

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In: Biological Psychiatry, Elsevier BV, ( 2023-2)

Type of Medium: Online Resource

ISSN: 0006-3223

URL: Article

DOI: 10.1016/j.biopsych.2023.01.023

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1499907-9

SSG: 12

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De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Wang, Sheng ; Mandell, Jeffrey D. ; Kumar, Yogesh ; [et al.]

Elsevier BV ; 2018

In: Cell Reports Vol. 24, No. 13 ( 2018-09), p. 3441-3454.e12

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In: Cell Reports, Elsevier BV, Vol. 24, No. 13 ( 2018-09), p. 3441-3454.e12

Type of Medium: Online Resource

ISSN: 2211-1247

URL: Article

DOI: 10.1016/j.celrep.2018.08.082

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2649101-1

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TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

Forde, Natalie J. ; Kanaan, Ahmad S. ; Widomska, Joanna ; [et al.]

Frontiers Media SA ; 2016

In: Frontiers in Neuroscience Vol. 10 ( 2016-08-23)

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In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 10 ( 2016-08-23)

Type of Medium: Online Resource

ISSN: 1662-453X

URL: Article

DOI: 10.3389/fnins.2016.00384

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2016

detail.hit.zdb_id: 2411902-7

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TopFed: TCGA Tailored Federated Query Processing and Linking to LOD

Saleem, Muhammad ; Padmanabhuni, Shanmukha S. ; Ngonga Ngomo, Axel-Cyrille ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Journal of Biomedical Semantics Vol. 5, No. 1 ( 2014), p. 47-

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In: Journal of Biomedical Semantics, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2014), p. 47-

Type of Medium: Online Resource

ISSN: 2041-1480

URL: Article

DOI: 10.1186/2041-1480-5-47

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2548651-2

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De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Wang, Sheng ; Mandell, Jeffrey D. ; Kumar, Yogesh ; [et al.]

Elsevier BV ; 2018

In: Cell Reports Vol. 25, No. 12 ( 2018-12), p. 3544-

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In: Cell Reports, Elsevier BV, Vol. 25, No. 12 ( 2018-12), p. 3544-

Type of Medium: Online Resource

ISSN: 2211-1247

URL: Article

DOI: 10.1016/j.celrep.2018.12.024

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2649101-1

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Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis

Tsetsos, Fotis ; Padmanabhuni, Shanmukha S. ; Alexander, John ; [et al.]

Frontiers Media SA ; 2016

In: Frontiers in Neuroscience Vol. 10 ( 2016-07-22)

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In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 10 ( 2016-07-22)

Type of Medium: Online Resource

ISSN: 1662-453X

URL: Article

DOI: 10.3389/fnins.2016.00340

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2016

detail.hit.zdb_id: 2411902-7

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Investigation of SNP rs2060546 Immediately Upstream to NTN4 in a Danish Gilles de la Tourette Syndrome Cohort

Padmanabhuni, Shanmukha S. ; Houssari, Rayan ; Esserlind, Ann-Louise ; [et al.]

Frontiers Media SA ; 2016

In: Frontiers in Neuroscience Vol. 10 ( 2016-11-22)

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In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 10 ( 2016-11-22)

Type of Medium: Online Resource

ISSN: 1662-453X

URL: Article

DOI: 10.3389/fnins.2016.00531

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2016

detail.hit.zdb_id: 2411902-7

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Epigenome-Wide Association Study of Tic Disorders

Zilhão, Nuno R. ; Padmanabhuni, Shanmukha S. ; Pagliaroli, Luca ; [et al.]

Cambridge University Press (CUP) ; 2015

In: Twin Research and Human Genetics Vol. 18, No. 6 ( 2015-12), p. 699-709

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In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 6 ( 2015-12), p. 699-709

Abstract: Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance ( p 〈 1.2 × 10 −7 ). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 ( p = 1.98 × 10 −6 ). Several of the top ranking probes ( p 〈 1 × 10 −4 ) were in or nearby genes previously associated with neurological disorders (e.g., GABBRI, BLM , and ADAM10 ), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10 −15 ) developmental process (GO:0032502, p = 2.96 × 10 −12 ), and cellular developmental process (GO:0048869, p = 1.96 × 10 −12 ). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

Type of Medium: Online Resource

ISSN: 1832-4274 , 1839-2628

URL: Article

DOI: 10.1017/thg.2015.72

Language: English

Publisher: Cambridge University Press (CUP)

Publication Date: 2015

detail.hit.zdb_id: 2184274-7

SSG: 12

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Combining Evidence of Preferential Gene-Tissue Relationships from Multiple Sources

Guo, Jing ; Hammar, Mårten ; Öberg, Lisa ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 8 ( 2013-8-12), p. e70568-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 8 ( 2013-8-12), p. e70568-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0070568

DOI: 10.1371/journal.pone.0070568.g001

DOI: 10.1371/journal.pone.0070568.g002

DOI: 10.1371/journal.pone.0070568.g003

DOI: 10.1371/journal.pone.0070568.g004

DOI: 10.1371/journal.pone.0070568.g005

DOI: 10.1371/journal.pone.0070568.g006

DOI: 10.1371/journal.pone.0070568.t001

DOI: 10.1371/journal.pone.0070568.t002

DOI: 10.1371/journal.pone.0070568.t003

DOI: 10.1371/journal.pone.0070568.t004

DOI: 10.1371/journal.pone.0070568.t005

DOI: 10.1371/journal.pone.0070568.t006

DOI: 10.1371/journal.pone.0070568.t007

DOI: 10.1371/journal.pone.0070568.s001

DOI: 10.1371/journal.pone.0070568.s002

DOI: 10.1371/journal.pone.0070568.s003

DOI: 10.1371/journal.pone.0070568.s004

DOI: 10.1371/journal.pone.0070568.s005

DOI: 10.1371/journal.pone.0070568.s006

DOI: 10.1371/journal.pone.0070568.s007

DOI: 10.1371/journal.pone.0070568.s008

DOI: 10.1371/journal.pone.0070568.s009

DOI: 10.1371/journal.pone.0070568.s010

DOI: 10.1371/journal.pone.0070568.s011

DOI: 10.1371/journal.pone.0070568.s012

DOI: 10.1371/journal.pone.0070568.s013

DOI: 10.1371/journal.pone.0070568.s014

DOI: 10.1371/journal.pone.0070568.s015

DOI: 10.1371/journal.pone.0070568.s016

DOI: 10.1371/journal.pone.0070568.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

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De Novo Sequence and Copy Number Variants are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Wang, Sheng ; Mandelll, Jeffrey D. ; Kumarr, Yogesh ; [et al.]

Elsevier BV ; 2018

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.3188485

Language: English

Publisher: Elsevier BV

Publication Date: 2018

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