In:
Annals of the New York Academy of Sciences, Wiley, Vol. 865, No. 1 ( 1998-12), p. 226-237
Abstract:
A bstract : VIP, which has been demonstrated to reduce or prevent oxidant injury in the lungs and other organs, is shown here to protect against excitotoxic injury of the lung and excitotoxic death of cortical neuronal cells in primary culture. Glutamate killing of neuron‐like PC‐12 cells, attributable to oxidant stress rather that to excitotoxicity, is also reduced or prevented by VIP and by the closely related peptide PACAP. The exact mechanisms of this protection remain to be determined, but appear to include antioxidant and anti‐apoptotic actions, and suppression of glutamate‐induced upregulation of its own receptor. Both VIP and PACAP offer the promise of novel and nontoxic means of defending against NMDA and glutamate toxicity.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.1998.865.issue-1
DOI:
10.1111/j.1749-6632.1998.tb11182.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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