In:
Vascular Surgery, SAGE Publications, Vol. 29, No. 5 ( 1995-09), p. 365-369
Abstract:
A light microscopy study was made of the structure of the left coronary, internal mammary, and renal arteries (LCA, IMA, RA) in 11 newborns after autopsy (mean age 22 ±22.6 days). Their intima and media thicknesses were measured. The mean intima/media ratios were: LCA 0.0745 ±0.0621; IMA 0.0837 ±0.0603, RA 0.0699 ± 0.0616. The only significant difference was between the media thicknesses of the LCA and the IMA (P=0.023). The media was thinnest in the IMA, thickest in the LCA. A previous study pointed out in adults, on the other hand, the intima thickness and the intima/media ratio are significantly different in the LCA as compared with the IMA and the RA. The ratio of only the neonatal LCA is significantly different from that of the adult (P=0.005). Media thickness in newborns and intima thickness in the adult are responsible for these differences in the ratio. The conclusion is drawn that the different structures present at birth are altered in function by the stress these arteries are subjected to and, more specifically, in direct proportion to increases in peripheral resistance. Another factor is the greater freedom of nutrition and metabolic exchange offered by the thin media of the IMA. This, indeed, may help to explain the relative immunity to atherosclerosis that has led to the use of this artery in bypass surgery.
Type of Medium:
Online Resource
ISSN:
0042-2835
DOI:
10.1177/153857449502900504
Language:
English
Publisher:
SAGE Publications
Publication Date:
1995
detail.hit.zdb_id:
2095223-5
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