In:
Infectious Diseases in Obstetrics and Gynecology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-4
Abstract:
The aim of this work was to study the anti- Candida activity of lidocaine and nitroglycerin alone and in combination. Ten Candida strains were included, corresponding to 1 collection type strain (ATCC 10231) and 9 clinical isolates: 4 C. albicans , 2 C. glabrata , 1 C. tropicalis , 1 C. krusei , and 1 C. parapsilosis . The CLSI reference M27-A3 micromethod was used to determine the anti- Candida activity of the drugs alone; minimal inhibitory and lethal concentrations were determined. The classic checkboard technique was used to determine the activity of combined drugs. Lidocaine fungicidal effect was dosedependent. Nitroglycerin exhibited a higher effect. The drugs combination resulted in a reduction of the inhibitory concentration, corresponding to an additive effect. In conclusion, both drugs exhibited an interesting anti- Candida activity. The combination of lidocaine with nitroglycerin was shown to have an additive effect against Candida spp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis.
Type of Medium:
Online Resource
ISSN:
1064-7449
,
1098-0997
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2001451-X
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