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  • 1
    Online Resource
    Online Resource
    World Scientific Pub Co Pte Ltd ; 2022
    In:  Journal of Mechanics in Medicine and Biology Vol. 22, No. 08 ( 2022-10)
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 22, No. 08 ( 2022-10)
    Abstract: A comprehensive review of applying Taguchi’s optimization methodology to medical facilities was evaluated in this study. Taguchi’s optimization methodology is one kind of robust designation and is reputed for integrating multiple factors to pursue one goal. According to Taguchi’s suggestion, the efficient and reliable arrangement of experimental groups with numerous factors shortened the observed timing and provided bountiful statistical data. Although this method is widely used in mechanical, civil, and chemical engineering fields, it became adopted in medical facilities only in the last decade. Most of Taguchi’s analyses focused on optimizing the imaging quality for diagnosis. The medical facilities include regular X-ray, cardiac X-ray, CT (computed tomography), CTA (computed tomography angiography), LINAC (medical linear accelerator), or gamma camera scans. The images were all manipulated according to various radiation-induced interactions; thus, the optimization process of imaging resolution can offer an essential contribution to this kind of facility. In this study, we summarized the Taguchi-related papers in medical facilities and evaluated common principles in organizing the unique orthogonal array, assigning various signal-to-noise ratios, using quantified gauges, and ranking or grading the obtained imaging quality in the datum analysis process. The further elaboration on how to preset the user demanded goal in the optimization process, the necessity of focusing on cross interaction among factors, dynamic analysis superiority over static one preset in Taguchi’s analysis, and how to preset an ideal signal-to-noise ratio to satisfy the researcher demand, the importance of verification or testification in clinical cases or the assistance of ANOVA to depict a complete concept of applying Taguchi’s optimization methodology.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    World Scientific Pub Co Pte Ltd ; 2019
    In:  Journal of Mechanics in Medicine and Biology Vol. 19, No. 07 ( 2019-11), p. 1940030-
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 19, No. 07 ( 2019-11), p. 1940030-
    Abstract: Objective: To optimize the minimum detectable difference (MDD) of a cardiac X-ray imaging system using the Taguchi L 8 (2 7 ) analysis and a precise line pair (LP) gauge. Methods: The optimal combination of the four critical factors of the cardiac X-ray imaging system, namely X-ray focus, kilovoltage (kVp), milliamper-seconds (mAs) and source image distance (SID), providing the MDD was calculated via the Taguchi analysis and experimentally verified. Two (low and high) levels were assigned for each factor, and eight combinations of four factors were used to acquire instant X-ray images using an NDT commercial LP gauge (with a gauge length of 64[Formula: see text]mm and a width of [Formula: see text] [Formula: see text]mm). The latter had five lines and was split gradually from top to bottom for the inspection of X-ray images, whose quality was ranked by three well-trained radiologists according to the double-blind criterion. The ranking grade was given by sharp contrast, low noise and precision to distinguish the LP. Accordingly, the MDD was derived to represent the spatial resolution of instant X-ray images by the revised Student’s [Formula: see text] -test analysis. The optimal combination of factors was experimentally identified and clinically verified in the follow-up inspections. Results: For the conventional setting, Group No. 7 (which obtained the highest grade among eight groups) and the optimal setting, the obtained MDD values were [Formula: see text], [Formula: see text] and [Formula: see text][Formula: see text] mm, respectively, while the LP (line pair/mm) interpolated from the gauge scale amounted to [Formula: see text], [Formula: see text] and [Formula: see text][Formula: see text] LP/mm, respectively. Conclusion: The Taguchi L 8 analysis was proved to be instrumental in optimizing the cardiac X-ray imaging system MDD and is recommended to be used jointly with the revised Student’s [Formula: see text]-test analysis for improving the spatial resolution of instant X-ray images.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2019
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  • 3
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 19, No. 08 ( 2019-12), p. 1940061-
    Abstract: In this study, a projection of effective blood concentration (EBC) readings of digoxin is made using the inverse problem algorithm based on clinical data for patients with heart failure diseases. Seven factors, including body surface area (BSA), blood urine nitrogen (BUN), creatinine, sodium (Na), potassium (K), magnesium (Mg) ion readings, and mean arterial pressure (MAP) were compiled with nonlinear regression fit to develop a projection function having 29 terms obtained from an inverse problem algorithm via the default function run in STATISTICA. Accordingly, data collected from the clinical 168 heart failure patients were normalized to be included in same domain range ([Formula: see text]1 to +1), and then calculated by the specific algorithm to optimize the numerical solution to evaluate EBC readings of digoxin. The evaluated first-order regression fit owned an optimal loss function ([Formula: see text] ) coupled with correlation coefficient [Formula: see text] = 0.892 and variance of 89.20%. Furthermore, 45 patients having similar clinical syndromes were also adopted to verify the projection and implied with high agreement. The BUN factor dominated the projection and defined as the most significant coefficient in the analysis, and K ion, MAP, BSA, and Mg ion factors exhibited minor contributions to the projection. The repeated trials to lower number of factors from seven to a smaller number (namely 6, 5, 4, 3, 2, and 1) for simplifying method but resulting with unaccepted outcomes, with high loss function values and low linearity. However, the algorithm held its accuracy to handle the verified data that were out of the original bounds. The proposed algorithm demonstrated a useful analysis to handle the drug administration in pharmaceutical field.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    World Scientific Pub Co Pte Ltd ; 2019
    In:  Journal of Mechanics in Medicine and Biology Vol. 19, No. 07 ( 2019-11), p. 1940042-
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 19, No. 07 ( 2019-11), p. 1940042-
    Abstract: Biokinetic model of Tc-99m MIBI for eight patients undergone myocardial perfusion examination was studied using gamma camera and MATLAB program. A six-compartment model was adopted to interpret the metabolic mechanism of each patient. Within the model framework, the respective set of simultaneous differential equations was solved by a self-developed program run in MATLAB. The experimental results exhibited a good fit with the theoretical predictions via the model. The average biological half-lives of body fluid, heart, thyroid, liver, GI Tract and remainder were assessed as [Formula: see text], [Formula: see text] , [Formula: see text], [Formula: see text] , [Formula: see text], and [Formula: see text] [Formula: see text]h, respectively. A dimensionless AT index of disagreement between the experimental data and MATLAB optimal solution was proposed of validating the applied acquisition system and analytical method feasibility. An AT of zero implies a perfect agreement between the theoretical and empirical results, while averages of the derived AT were fluctuated from 3 [Formula: see text] 2 to [Formula: see text] for five compartments. The proposed refined equation estimated the internal dose from gamma-ray as [Formula: see text] [Formula: see text]mSv for eight patients according to a fast screening method, which defined human body as a spherical ball to simplify the calculation in reality. The proposed MATLAB-based fitting of in-vivo data with the theoretical results was instrumental for assessing the radiation dose received by the Tc-99m MIBI scan participants.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2019
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  • 5
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 21, No. 10 ( 2021-12)
    Abstract: Subject: This study assessed the absorbed dose for patients who underwent Tc-99m Methylene Diphosphonates (MDP) bone scan examination based on a series of personal dosimeter measurements and a derived semi-empirical formula. Material and methods: 210 volunteers among the patients, who were administrated 925 MBq Tc-99m MDP for the bone scan examination in the Department of Nuclear Medicine in the Dalin Tuzchi Hospital, Taiwan, underwent personal dosimeter measurements at 30, 120, and 180[Formula: see text]min after the injection. A personal dosimeter was held at a 30[Formula: see text] cm distance from the patient’s stomach. The acquired data were analyzed to derive the residence time of Tc-99m radionuclide in the patient’s body. Five biological parameters (gender, age, BMI, eGFR, and creatinine) of these 210 patients were collected and processed by the STATISTICA program, yielding a nonlinear 16-term first-order semi-empirical formula for the radionuclide residence time prediction. The respective four- and three-factor calculations, excluding creatinine and eGFR, provided poor correlation. Results and Conclusion: According to the phantom concept, treating a patient’s body as a homogenous spherical ball, a simplified formula was used to assess the absorbed dose rate and magnitude. Therefore, the derived residence time, dose rate, and absorbed dose were [Formula: see text][Formula: see text] min, [Formula: see text]Sv/min, and [Formula: see text] Sv, respectively. These results were lower than those obtained in previous studies, which can be attributed to accelerated radionuclide excretion of patients who drank 2000 cc of water after the procedure, yielding shorter residence times.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    World Scientific Pub Co Pte Ltd ; 2020
    In:  Journal of Mechanics in Medicine and Biology Vol. 20, No. 10 ( 2020-12), p. 2040045-
    In: Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Ltd, Vol. 20, No. 10 ( 2020-12), p. 2040045-
    Abstract: In this study, the correlation between triggered timing for head and neck CT angiography (TT CTA) scanning and the average of CT values of both left and right arterial to upper sinuses (LRA/US) reaching a maximal ratio was surveyed and explored using the inverse problem algorithm according to a six-factor semi-quantitative analysis of 251 patients. Six risk factors, namely TT CTA, mean arterial pressure (MAP), heart rate (HR), contrast media solution (CMS), given pressure (Pre), and body surface area (BSA) were used to identify a nonlinear first-order regression correlation between projected and actual LRA/US values. The respective 22 terms were derived via the STATISTICA program. In doing so, a customized loss function ([Formula: see text]) was defined according to the total fluctuation between theoretically projected and actual LRA/US values for all 216 patients. Thus, [Formula: see text] individual data points were included in the algorithm to optimize the compromised solution array [[Formula: see text]] of LRA/US values. The results exhibited a close correlation with loss function [Formula: see text] , correlation coefficient [Formula: see text], and a 93.13% variance. Another group of 35 patients with similar symptoms was selected to verify the prediction accuracy and exhibited a high coincidence, although the reverse calculation-based correlation between CC CTA and LRA/US was still controversial from a clinical viewpoint. The proposed algorithm is considered quite instrumental in predicting the LRA/US with ischemic stroke symptoms in the CTA examination.
    Type of Medium: Online Resource
    ISSN: 0219-5194 , 1793-6810
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2020
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  • 7
    In: Computer Assisted Surgery, Informa UK Limited, Vol. 22, No. sup1 ( 2017-10-31), p. 70-78
    Type of Medium: Online Resource
    ISSN: 2469-9322
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2870722-9
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  • 8
    Online Resource
    Online Resource
    Informa UK Limited ; 2016
    In:  Bioengineered Vol. 7, No. 4 ( 2016-07-03), p. 226-234
    In: Bioengineered, Informa UK Limited, Vol. 7, No. 4 ( 2016-07-03), p. 226-234
    Type of Medium: Online Resource
    ISSN: 2165-5979 , 2165-5987
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2737830-5
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  • 9
    In: Bio-Medical Materials and Engineering, IOS Press, Vol. 26, No. s1 ( 2015-08-17), p. S1651-S1658
    Type of Medium: Online Resource
    ISSN: 1878-3619 , 0959-2989
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2015
    detail.hit.zdb_id: 2011596-9
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  • 10
    In: Applied Sciences, MDPI AG, Vol. 12, No. 5 ( 2022-03-05), p. 2708-
    Abstract: This study tried to propose an innovated idea of solidifying the resolution of gamma camera in routine quality control and recommended a quantified index as minimum detectable difference (MDD) of gamma camera SPECT images using the Taguchi analysis and an indigenous V-shaped slit gauge. The gauge was customized to fulfill the quantitative requirement of the Taguchi analysis. The MDD among slit gauge of derived SPECT image was calculated from two overlapped peak profiles collected from a tangent slice of the V-shaped slit gauge with two nearby peaks. In particular, MDD was evaluated as minimum distance between two peak centers through the Student’s t-test with a constant, 1.96, which indicates that two peak centers separated distant enough to create a 95% confidence level of separation. Eighteen combinations of six gamma camera scanned factors were organized according to Taguchi analysis. Accordingly, (A) collimator, (B) detector to targe distance, (C) total counts, (D) acquired energy width, (E) Matrix size, and (F) zoom of collected ROI with each of two or three levels were organized into 18 groups to collect the slit gauge images according to Taguchi L18 orthogonal array. Then, three well-trained radiologists were ranked the scanned gauge images to derive the fish-bone-plot of signal-to-noise ratio (S/N, dB) and correlated ANOVA. Furthermore, the quantified MDD was proposed to verify the optimal suggestion of gamma camera scanned protocol, and obtained the MDD as 8.4, 7.9, and 7.1 mm for the second group of original L18 preset, conventional, and the optimal preset, respectively. Thus, the optimal preset of gamma camera was achieved in this study. The MDD proved to be a successful index in quantifying the imaging resolution of a gamma camera.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2704225-X
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