X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Association of race and health care system with disease stage and survival in veterans with larynx cancer
    Wiley ; 2021
    In:  Cancer Vol. 127, No. 15 ( 2021-08), p. 2705-2713
    Details
    In: Cancer, Wiley, Vol. 127, No. 15 ( 2021-08), p. 2705-2713
    Abstract: Within the “equal‐access” veterans' health system, Black and White patients with larynx cancer have similar disease burdens at diagnosis and similar larynx cancer survival outcomes. These observations, in contrast to Surveillance, Epidemiology, and End Results data, suggest that health care access may be a significant mediator of race‐based larynx cancer survival disparities.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v127.15
    DOI: 10.1002/cncr.33557
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 2
    Online Resource
    Online Resource
    Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion
    Wiley ; 2015
    In:  The Laryngoscope Vol. 125, No. 5 ( 2015-05)
    Details
    In: The Laryngoscope, Wiley, Vol. 125, No. 5 ( 2015-05)
    Abstract: Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis. Study Design Retrospective single institution cohort study. Methods Retrospective chart review of imaging, clinical, pathological, and follow‐up data of 51 patients who underwent mandibular resections with intraoperative bone‐marrow cytologic evaluation. The accuracy of bone marrow cytologic evaluations to predict final bone margins was calculated. Five‐year survival rates were determined. Results The accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by SCCa beyond the original margins of bone resection was 100%. Twelve percent (6/51) were found to have positive bone margins on cytology and were re‐resected to obtain clear margins. Patients with a prior history of radiation had a significantly higher incidence of initially positive bone‐marrow margins ( P  = 0.03). The patients with initially positive bone‐margins did not have a significantly different prognosis than the patients with initially negative bone‐marrow margins. Conclusion 1) The consistent use of intraoperative bone‐marrow cytologic evaluation, when applicable, will improve the ability to obtain clear bone margins. 2) Patients with a history of prior radiation therapy have a significantly higher risk of having occult cancellous invasion of SCCa beyond the original margins of bone resection. 3) The prognosis of patients with initially positive bone‐marrow margins is not significantly different than patients with initially negative bone‐marrow margins. Level of Evidence 4. Laryngoscope , 125:E173–E179, 2015
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v125.5
    DOI: 10.1002/lary.25063
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2026089-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 3
    Online Resource
    Online Resource
    Prognostic Significance of HPV Status in Laryngeal Squamous Cell Carcinoma: A Large‐Population Database Study
    Wiley ; 2021
    In:  Otolaryngology–Head and Neck Surgery Vol. 165, No. 1 ( 2021-07), p. 113-121
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 165, No. 1 ( 2021-07), p. 113-121
    Abstract: To explore the survival implications of human papillomavirus (HPV) positivity and subtype in larynx cancer through a national cancer database. To investigate staging discrepancies in larynx cancer associated with HPV status. Study Design Retrospective observational cohort study. Setting National Cancer Database. Methods Data were extracted concerning adults with known HPV status who were treated between 2010 and 2016 for laryngeal squamous cell carcinoma. Patients without known HPV subtype were excluded. Cox multivariable regression models were fit to evaluate the survival impact of HPV status, characterized as a binary variable (HPV+ vs HPV–) and by subtype. Two‐ and 5‐year survival rates were calculated via the Kaplan‐Meier method and compared by stage between the HPV+ and HPV– cohorts per the log‐rank test. Results Patients with HPV+ larynx cancer were younger (60.5 vs 64.3 years, P 〈 . 001), more likely to have private insurance (37.2% vs 31.2%, P 〈 . 001), more commonly White (84.6% vs 82.4%, P =. 013), and more likely to present with nodal disease (42.6% vs 33.0%, P 〈 . 001). HPV positivity and HPV subtype 16 were associated with improved overall survival. One‐stage discrepancies in 5‐year survival were observed between the HPV+ and HPV– cohorts: stage II HPV+ (69.45%) vs stage I HPV– (65.77%); stage IV HPV+ (47.67%) vs stage III HPV– (46.80%). Conclusions HPV positivity and infection with HPV subtype 16 are correlated with improved overall survival in patients with laryngeal squamous cell carcinoma, manifesting with a 1‐stage incremental survival advantage. Future prospective studies are indicated to corroborate the findings from this large‐population database retrospective study.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599820976178
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2008453-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 4
    Online Resource
    Online Resource
    Opioid prescribing practices in patients undergoing surgery for oral cavity cancer
    Wiley ; 2018
    In:  The Laryngoscope Vol. 128, No. 10 ( 2018-10), p. 2361-2366
    Details
    In: The Laryngoscope, Wiley, Vol. 128, No. 10 ( 2018-10), p. 2361-2366
    Abstract: Opioids have been overprescribed after general and orthopedic surgeries, but prescribing patterns have not been reported for head and neck surgery. The objectives of this retrospective review are to describe postoperative opioid prescriptions after oral cancer surgery and determine which patients receive higher amounts. Methods A single institution retrospective review was performed for 81 adults with oral cavity tumors undergoing surgery. Opioid prescriptions upon discharge were reported in daily oral morphine equivalents (OME). High opioids were defined as  〉  90 mg daily and  〉  200 mg total, commensurate with U.S. Center for Disease Control and Prevention and state guidelines. Multivariable logistic regression was performed to investigate factors associated with high opioids. Results The median number of doses dispensed was 30 (interquartile range [IQR] 30–45; range 3–120). The median daily dose was 30 mg (IQR 20–45 mg; range 15–240 mg). Five patients (6%) received higher than the recommended daily dose. The median total dispensed amount was 225 mg (IQR 150–250 mg; range 15–1200 mg). Fifty‐one (63%) received greater than the recommended total dose. On multivariable logistic regression, advanced tumor stage (odds ratio [OR] 11.5; 95% confidence interval [CI] 1.2–109.4; P  = 0.034) and inpatient pain scores (OR 1.3 per 1‐unit increase; 95% CI 1.0–1.7; P  = 0.039) were associated with receiving high total opioids after surgery. Conclusion The majority of patients received greater than the recommended 200 mg total OME. Advanced stage and higher inpatient pain scores were associated with receiving more opioids for discharge. Consensus‐driven analgesic plans are needed to reduce excess opioids after discharge following head and neck surgery. Level of Evidence 4. Laryngoscope , 128:2361–2366, 2018
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v128.10
    DOI: 10.1002/lary.27215
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2026089-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 5
    Online Resource
    Online Resource
    Predictors of Quality‐of‐Life Improvements Following Global Head and Neck Surgery Trips to Underserved Regions
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 9 ( 2021-09), p. 2006-2010
    Details
    In: The Laryngoscope, Wiley, Vol. 131, No. 9 ( 2021-09), p. 2006-2010
    Abstract: To conduct longitudinal postoperative follow‐up and discern health‐related quality‐of‐life (HR‐QoL) changes using a validated questionnaire among patients undergoing head and neck surgeries during a short‐term, global surgical trip in a resource‐limited setting. To identify clinicodemographic predictors of post‐operative HR‐QoL improvements in this setting. Study Design Retrospective observational study with prospective follow‐up. Methods Patients undergoing surgery at Moi Teaching and Referral Hospital in Eldoret, Kenya through the authors' short‐term surgical trip (STST) between 2016 and 2019 were asked to complete preoperative Short Form‐36 (SF‐36) HR‐QoL questionnaires, and postoperative SF‐36 questionnaires during subsequent follow‐up. Preoperative and postoperative SF‐36 domain scores, and two composite scores (mental component summary [MCS] and physical component summary [PCS] ) were compared. Linear regression models were fit to identify clinicodemographic factors predictors of general health (GH), MCS, and PCS scores. Results Among the 26 participating patients, significant improvements were seen in post‐operative GH (mean change = 19.8) and MCS (mean change = 11.2) scores. Lower pre‐operative GH, MCS, and PCS scores were predictive of greater improvement in the corresponding post‐operative scores. Longer time to follow‐up was associated with greater improvement in GH score. Mean follow‐up interval was 23.1 months (SD = 1.8 months). Conclusions Utilizing the SF‐36 questionnaire, we found that patients' perception of their general and psychosocial health improved after undergoing head and neck surgeries through a global STST. This study provides important, preliminary evidence that that elective surgeries performed in low‐resource settings convey substantial benefit to patient QoL. Level of Evidence 4 Laryngoscope , 131:2006–2010, 2021
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v131.9
    DOI: 10.1002/lary.29522
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026089-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 6
    Online Resource
    Online Resource
    Patterns of Failure After Definitive Treatment of T4a Larynx Cancer
    Wiley ; 2022
    In:  Otolaryngology–Head and Neck Surgery Vol. 167, No. 2 ( 2022-08), p. 274-285
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 167, No. 2 ( 2022-08), p. 274-285
    Abstract: Recurrence is known to predict laryngeal squamous cell cancer (LSCC) survival. Recurrence patterns in T4a LSCC are poorly characterized and represent a possible explanation for observed survival discrepancies by treatment rendered. Study Design Retrospective database review. Setting Veterans Affairs national database. Methods Patients with T4a LSCC between 2000 and 2017 were identified and stratified by treatment (chemoradiotherapy [CRT] vs total laryngectomy + neck dissection + adjuvant therapy [surgical] ). Primary outcomes were locoregional and distant recurrence. Secondary outcomes of overall mortality, larynx cancer mortality, and noncancer mortality were evaluated in Cox and Fine‐Gray models. Results A total of 1043 patients had comparable baseline demographics: 438 in the CRT group and 605 in the surgical group. Patients undergoing CRT had higher proportions of node positivity (64.6% vs 53.1%, P 〈 . 001). Locoregional and distant recurrence were less common in the surgical group (23.0% vs 37.2%, P 〈 . 001; 6.8% vs 13.3%, P 〈 . 001, respectively); however, distant metastatic rates did not differ within the N0 subgroup ( P =. 722). On multivariable regression, surgery demonstrated favorable locoregional recurrence (hazard ratio [HR], 0.49; 95% CI, 0.39‐0.62; P 〈 . 001), distant recurrence (HR, 0.47; 95% CI, 0.31‐0.71; P 〈 . 001), overall mortality (HR, 0.75; 95% CI, 0.64‐0.87; P 〈 . 001), and larynx cancer mortality (HR, 0.69; 95% CI, 0.56‐0.85; P 〈 . 001). Conclusion T4a LSCC survival discrepancies between surgical and nonsurgical treatment are influenced by varying recurrence behaviors. Surgery was associated with superior disease control and improved survival. Beyond the known benefit in locoregional control with surgery, there may be a protective effect on distant recurrence that depends on regional disease burden.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/01945998211049211
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2008453-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 7
    Online Resource
    Online Resource
    Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
    American Association for Cancer Research (AACR) ; 2020
    In:  Clinical Cancer Research Vol. 26, No. 11 ( 2020-06-01), p. 2693-2703
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 26, No. 11 ( 2020-06-01), p. 2693-2703
    Abstract: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannabinoids and HPV-positive HNSCC. Experimental Design: The expression of cannabinoid receptors CNR1 and CNR2 was analyzed using The Cancer Genome Atlas (TCGA) HNSCC data. We used agonists, antagonists, siRNAs, or shRNA-based models to explore the roles of CNR1 and CNR2 in HPV-positive HNSCC cell lines and animal models. Cannabinoid downstream pathways involved were determined by Western blotting and analyzed in a primary HPV HNSCC cohort with single-sample gene set enrichment analysis (ssGSEA) and the OncoGenome Positioning System (Onco-GPS). Results: In TCGA cohort, the expression of CNR1 and CNR2 was elevated in HPV-positive HNSCC compared with HPV-negative HNSCC, and knockdown of CNR1/CNR2 expression inhibited proliferation in HPV-positive HNSCC cell lines. Specific CNR1 and CNR2 activation as well as nonselective cannabinoid receptor activation in cell lines and animal models promoted cell growth, migration, and inhibited apoptosis through p38 MAPK pathway activation. CNR1/CNR2 antagonists suppressed cell proliferation and migration and induced apoptosis. Using whole-genome expression analysis in a primary HPV HNSCC cohort, we identified specific p38 MAPK pathway activation signature in tumors from HPV HNSCC patients with objective measurement of concurrent cannabinoid exposure. Conclusions: Cannabinoids can promote progression of HPV-positive HNSCC through p38 MAPK pathway activation.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1078-0432.CCR-18-3301
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 8
    Online Resource
    Online Resource
    Detecting Mild Phonotrauma in Daily Life
    Wiley ; 2023
    In:  The Laryngoscope
    Details
    In: The Laryngoscope, Wiley
    Abstract: The aim of this study was to gain quantitative insights into the role of daily voice use associated with mild phonotrauma via the Daily Phonotrauma Index (DPI), a measure derived from neck‐surface acceleration magnitude (NSAM) and difference between the first two harmonic magnitudes (H1 − H2). Methods An ambulatory voice monitor recorded weeklong voice use for 151 female patients with phonotraumatic vocal hyperfunction (PVH) and 181 female vocally healthy controls. Three laryngologists rated phonotrauma severity from each patient's laryngoscopy. Mixed generalized linear models evaluated the accuracy, sensitivity, and specificity of the original DPI trained on all patients versus a mild DPI version trained on only patients rated with mild phonotrauma. Individual contribution of NSAM and H1 − H2 to each DPI model was also evaluated. Results Reliability across the laryngologists' phonotrauma ratings was moderate (Fleiss κ  = 0.41). There were 70, 69, and 12 patients with mild, moderate, and severe phonotrauma, respectively. The mild DPI, compared to the original DPI, correctly classified more patients with mild phonotrauma (Cohen's d  = 0.9) and less controls ( d  = −0.9) and did not change in overall accuracy. H1 − H2 contributed less to mild phonotrauma classification than NSAM for mild DPI. Conclusions Compared with the original DPI, the mild DPI exhibited higher sensitivity to mild phonotrauma and lower specificity to controls, but the same overall classification accuracy. These results support the mild DPI as a promising detector of early phonotrauma and that NSAM may be associated with early phonotrauma, and H1 − H2 may be a biomarker associated with vocal fold vibration in the presence of lesions. Level of Evidence Level 4, case–control study Laryngoscope , 2023
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Article
    DOI: 10.1002/lary.30750
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2026089-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 9
    Online Resource
    Online Resource
    Rate and Factors Associated With Change in Surgeon for Revision Endoscopic Sinus Surgery
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 4 ( 2021-04)
    Details
    In: The Laryngoscope, Wiley, Vol. 131, No. 4 ( 2021-04)
    Abstract: A subset of patients will undergo revision endoscopic sinus surgery (ESS) with a different otolaryngologist than the one who performed their primary surgery. The purpose of this study is to report the incidence of and clinicodemographic factors associated with a change in surgeon for revision ESS. Study Design Retrospective cohort study. Methods Adult patients who underwent at least two outpatient ESS procedures between 2009 and 2014 using the State Ambulatory Surgery Database for Florida were included in the study. Change in surgeon was defined by a change in a unique provider identifier for the revision procedure. Multivariable regression analysis was used to determine characteristics associated with a change in surgeon. Results A total of 2,963 patients were included. For the revision procedure, 47.7% of patients changed their surgeon. On multivariable logistic regression, a medium‐ (odds ratio [OR]: 0.64; 95% confidence interval [CI] : 0.53‐0.77) or high‐volume (OR: 0.50; 95% CI: 0.42‐0.61) surgeon performing the index surgery and advanced age (≥65 years) (OR: 0.79; 95% CI: 0.63‐0.99) were associated with decreased odds of surgeon change for revision ESS. Longer time elapsed between index and revision surgery (OR: 1.15; 95% CI: 1.13‐1.17) was associated with increased odds of surgeon change. Conclusions Nearly half of patients who undergo revision ESS select a surgeon other than the one who performed their primary procedure. Surgeon volume, age, and time between surgeries affect the likelihood of a change in surgeon for revision ESS. These findings may provide introductory insights into patient preferences and decision making in the surgical management of recalcitrant chronic rhinosinusitis. Level of Evidence 4 Laryngoscope , 131:E1049–E1053, 2021
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v131.4
    DOI: 10.1002/lary.29012
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026089-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 10
    Online Resource
    Online Resource
    Short-Term Morbidity after the Endoscopic Modified Lothrop (Draf-III) Procedure Compared with Draf-IIa
    SAGE Publications ; 2017
    In:  American Journal of Rhinology & Allergy Vol. 31, No. 4 ( 2017-07), p. 265-270
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 31, No. 4 ( 2017-07), p. 265-270
    Abstract: The endoscopic modified Lothrop (Draf-III) surgery has improved treatment of recalcitrant frontal sinus disease, with favorable safety and long-term results. However, the short-term clinical and quality-of-life morbidity after Draf-III relative to less-extensive procedures has yet to be investigated. Objective To evaluate the surgical and quality-of-life outcomes, including the burden of follow-up care, in patients who underwent endoscopic modified Lothrop (Draf-III), and compared these results with a less-extensive intervention, the endoscopic frontal sinusotomy (Draf-IIa). Methods A retrospective review of early ( 〈 8 weeks) postoperative recovery of patients who underwent Draf-III (2014 to 2016) for chronic rhinosinusitis was conducted and compared with age and radiographically matched Draf-IIa controls. Primary outcomes included perioperative complications, the number of postoperative clinic visits, debridements, and steroid and antibiotic therapy days. Secondary outcomes included the change in the 22-item Sino-Nasal Outcome Test (SNOT-22) scores and/or subscores (domains). Results Thirty-eight patients (19 Draf-III, 19 Draf-IIa) were included. Patients who underwent Draf-III versus Draf-IIa required more postoperative clinic visits (4.9 ±1.7 versus 3.3 ± 0.8; p 〈 0.05), debridements (4.2 ± 2.0 versus 2.3 ± 0.8; p 〈 0.05), and antibiotic therapy days (24.4 ± 11.8 versus 15.6 ± 6.3; p 〈 0.05). The mean (SD) SNOT-22 scores improved for both groups (−12.7 ± 34.5 versus -9.5 ± 20.4; p = 0.74) over the follow-up period, and subscore (domain) analysis demonstrated worsening extranasal symptoms (2.5 ± 3.0 versus -1.5 ± 4.7; p 〈 0.05) at the first postoperative visit, and less improvement in ear/facial symptoms at the second (−0.5 ± 2.6 versus -3.9 ± 4.7; p = 0.03) and third postoperative visits (−1.1 ± 1.6 versus 3.5 ± 3.3; p = 0.01). Conclusion Draf-III is associated with more postoperative clinic visits, debridements, and antibiotic therapy days. The patients who underwent Draf-III demonstrated worsening of extranasal symptoms at the first postoperative visit and less improvement in the ear/facial score at the second and third visits. Informed consent and counseling patients who may require Draf-III should include a detailed discussion of the burden of postoperative care and recovery.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2017.31.4450
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2554548-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages