In:
Journal of Heterocyclic Chemistry, Wiley, Vol. 54, No. 6 ( 2017-11), p. 3418-3426
Abstract:
Structurally diverse spiroheterocycles; spiro[pyrimido[2,1‐ b ]benzothiazole‐3,3′‐chromene] ‐2′,4′‐dione, spiro[pyrimido[2,1‐ b ]benzothiazole‐3,5′‐pyrimidine] ‐2′,4′,6′‐trione, and spiro[pyrimido[2,1‐ b ]benz‐thiazole‐3,2′‐cyclohexane] ‐1′,3′‐dione have been synthesized by an environmentally benign, efficient, and facile one‐pot pseudo‐four component reaction of 2‐aminobenzothiazoles with aromatic aldehydes and cyclic β‐diketones in aqueous medium. The process involves hetero‐Diels–Alder cycloaddition and provides facile access to spiroheterocycles fused with potentially interesting biologically active scaffolds. The configuration of hetero‐Diels–Alder cycloadduct has been ascertained through density functional theory calculations.
Type of Medium:
Online Resource
ISSN:
0022-152X
,
1943-5193
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2042274-X
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