In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-2), p. e0242770-
Abstract:
We hypothesized that differences in the microbiome could be a cause of the substantial differences in the symptoms of and treatment options for adult and pediatric patients with chronic rhinosinusitis (CRS). First, we characterized the differences in the nasal microbiomes of pediatric and adult CRS patients. Swabs were obtained from 19 patients with chronic rhinosinusitis (9 children and 10 adults). The bacterial 16S rRNA gene was pyrosequenced to compare the microbiota of the middle meatus. No significant differences were found in species richness and alpha-diversity indices between the two groups. However, in the comparison of diversity between groups using the unweighted pair group method with arithmetic mean (UPGMA) clustering of microbiome taxonomic profiles, we observed a relatively clear separation between the adult and pediatric groups. Actinobacteria had a significantly higher relative abundance in the adult group than in the pediatric group at the phylum level. At the genus level, Corynebacterium showed significantly higher relative abundance in the adult group than in the pediatric group. This is a comparative study between the microbiomes of adult and pediatric CRS patients. We expect this study to be the first step in understanding the pathogenesis of CRS in adults and children using microbiome analysis.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0242770
DOI:
10.1371/journal.pone.0242770.g001
DOI:
10.1371/journal.pone.0242770.g002
DOI:
10.1371/journal.pone.0242770.g003
DOI:
10.1371/journal.pone.0242770.g004
DOI:
10.1371/journal.pone.0242770.t001
DOI:
10.1371/journal.pone.0242770.s001
DOI:
10.1371/journal.pone.0242770.s002
DOI:
10.1371/journal.pone.0242770.r001
DOI:
10.1371/journal.pone.0242770.r002
DOI:
10.1371/journal.pone.0242770.r003
DOI:
10.1371/journal.pone.0242770.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
Bookmarklink