In:
Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 59, No. 9 ( 2010-02-18), p. 1279-1285
Abstract:
Fructus Ligustrum lucidi (FLL) is a widely used herbal medicine for the treatment of a variety of pathologies. We have investigated the anti-inflammatory mechanism of FLL in mouse peritoneal macrophages. FLL exerted an anti-inflammatory action through inhibition of lipopolysaccharide (LPS)-induced tumour necrosis factor (TNF)-α production in mouse peritoneal macrophages. The maximal inhibition rate of TNF-α production by FLL (0.5 mg mL−1) was 60.88 + 0.30%. In the inflammatory process, nitric oxide (NO) and prostaglandin E2 (PGE2) increased in peritoneal macrophages. FLL decreased the protein level of NO and PGE2 in LPS-stimulated mouse peritoneal macrophages. In addition, FLL inhibited nuclear factor-κB activation and IκB-α degradation by the decrease in IκB-α phosphorylation. Our study suggested that FLL reduced inflammation via an important molecular mechanism, which might explain its beneficial effect in the regulation of inflammatory reactions.
Type of Medium:
Online Resource
ISSN:
0022-3573
,
2042-7158
DOI:
10.1211/jpp.59.9.0013
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2010
detail.hit.zdb_id:
2041988-0
detail.hit.zdb_id:
2050532-2
SSG:
15,3
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