In:
Journal of the American Geriatrics Society, Wiley, Vol. 41, No. 8 ( 1993-08), p. 818-822
Abstract:
Objective: To determine the effects of long‐term use of the thiazide diuretic chlorthalidone on serum bone‐related biochemical variables in older persons. Design : Cross‐sectional comparison. Setting : Community‐dwelling subjects who had participated in the Systolic Hypertension in the Elderly (SHEP) program. Participants : Sixty‐six Caucasians (36 male and 30 female), age range 70 to 89 years, of whom 23 were taking a thiazide diuretic. Measurements : 25‐hydroxyvitamin D (25OHD), parathyroid hormone, osteocalcin, calcitonin, and serum bioavailable testosterone. Results : In both groups, there was a high prevalence of low 25 (OHD) levels (30%). Log 25OHD showed a significant inverse relationship to parathyroid hormone ( r = .33, P 〈 0.05). Thiazide users had lower levels of osteocalcin ( P 〈 0.05) and parathyroid hormone levels ( P 〈 0.05) compared with non‐thiazide users. Male thiazide users had decreased bioavailable testosterone levels compared with non‐thiazide users ( P 〈 0.05). Serum osteocalcin was significantly related to bioavailable testosterone in men not on thiazide ( r = .43, P 〈 0.05). Conclusions : Hypovitaminosis D is a common finding in older individuals with associated elevations in parathyroid hormone. Parathyroid hormone and testosterone concentration (in men) are correlated with serum osteocalcin, a measure of osteoblastic activity. Long‐term thiazide use alters these relationships and produces a biochemical profile suggestive of decreased bone formation. Reduced bioavailable testosterone may also play a role in these biochemical changes.
Type of Medium:
Online Resource
ISSN:
0002-8614
,
1532-5415
DOI:
10.1111/jgs.1993.41.issue-8
DOI:
10.1111/j.1532-5415.1993.tb06176.x
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
2040494-3
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