In:
EMBO reports, EMBO, Vol. 24, No. 3 ( 2023-03-06)
Abstract:
image Cholesterol 25‐hydroxylase (Ch25h) expression increases in central nervous system‐endothelial cells (ECs) during inflammation and regulates lipid secretion. Partial loss of Ch25h in ECs promotes polymorphonuclear myeloid‐derived suppressor cell (PMN‐MDSC) expansion and reduces experimental autoimmune encephalomyelitis (EAE) severity. Ch25h expression and related 25‐hydroxycholesterol (25‐OHC) are increased in ECs during neuroinflammation. Ch25h‐specific ablation from the microvascular endothelium alters fatty acid desaturase 2 (FADS2) expression, which promotes the production of anti‐inflammatory lipids, in particular Prostaglandin E2 (PGE2). 25‐OHC and PGE2 control PMN‐MDSC expansion. Partial loss of Ch25h promotes PMN‐MDSC accumulation within the central nervous system (CNS) and attenuates EAE.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255328
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12
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